US4806543A
Expired / Lapsed
US
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Method and compositions for reducing neurotoxic injury
Assignee: Leland Stanford Junior University
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Filing: 1986-11-25
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Granted: 1989-02-21
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Expires: 2006-11-25
Abstract
Abstract A method for reducing adverse effects of neurotoxic injury, which comprises administering to a patient susceptible to neurotoxic injury an effective amount, sufficient to reduce the injury, of a compound which is an enantiomer of an analgesic opioid agonist or antagonist, preferably an opiate agonist having a ring system of the following stereochemistry, which shows only carbon and nitrogen atoms in the rings: <IMAGE> The dextrorotatory opiates, dextrorphan and dextromethorphan, are particularly suitable for use in the method of the invention.
Inventors
- 👤 Dennis W. Choi
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-05 09:06
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/33; A61K31/395; A61K31/435; A61K31/47; A61K31/485; A61P; A61P25/00; A61P25/08; A61P25/28; A61P3/00; A61P3/08; A61P9/00; A61P9/10
Claims Analysis
Total Claims: 20
Claim 1
Independent Claim
44 words
A method for reducing adverse effects of toxic injury to central neurons, which comprises: administering to a patient susceptible to toxic injury an amount, sufficient to reduce said effects, of a compound which is a mirror-image enantiomer of an analgesic opioid agonist or antagonist.
Claim 2
Independent Claim
44 words
A method for reducing adverse effects of toxic injury to central neurons, which comprises: administering to a patient susceptible to toxic injury an amount, sufficient to reduce said effects, of a compound which is a mirror-image enantiomer of an analgesic opioid agonist or antagonist.
Claim 3
Dependent Claim
16 words
The method of claim 1, wherein said compound is an enantiomer of an analgesic opiate agonist.
Claim 4
Dependent Claim
11 words
The method of claim 2, wherein said compound is a morphinan.
Claim 5
Dependent Claim
13 words
The method of claim 3, wherein said compound is a N-methyl-3-(hydroxy or alkoxy)morphinan.
Claim 6
Dependent Claim
10 words
The method of claim 1, wherein said compound is dextrorphan.
Claim 7
Dependent Claim
10 words
The method of claim 1, wherein said compound is dextromethorphan.
Claim 8
Dependent Claim
20 words
The method of claim 1, wherein said toxic injury associated with ischemia, hypoxia, hypoglycemia, epilepsy, Huntington's disease, or Alzheimer's disease.
Claim 9
Dependent Claim
11 words
The method of claim 1, wherein said patient is a human.
Claim 10
Independent Claim
49 words
A method for reducing toxic injury to central neurons mediated by an endogenous excitatory amino acid, which comprises: administering to a patient susceptible to said toxic injury an amount, sufficient to reduce said injury, of a compound which is a mirror-image enantiomer of an analgesic opioid agonist or antagonist.
Claim 11
Independent Claim
49 words
A method for reducing toxic injury to central neurons mediated by an endogenous excitatory amino acid, which comprises: administering to a patient susceptible to said toxic injury an amount, sufficient to reduce said injury, of a compound which is a mirror-image enantiomer of an analgesic opioid agonist or antagonist.
Claim 12
Dependent Claim
17 words
The method of claim 9, wherein said compound is a mirror-image enantiomer of an analgesic opiate agonist.
Claim 13
Dependent Claim
11 words
The method of claim 10, wherein said compound is a morphinan.
Claim 14
Dependent Claim
13 words
The method of claim 11, wherein said compound is a N-methyl-3-(hydroxy or alkoxy)morphinan.
Claim 15
Dependent Claim
10 words
The method of claim 9, wherein said compound is dextrorphan.
Claim 16
Dependent Claim
10 words
The method of claim 9, wherein said compound is dextromethorphan.
Claim 17
Dependent Claim
20 words
The method of claim 9, wherein said toxic injury results from ischemia, hypoxia, hypoglycemia, epilepsy, Huntington's disease, or Alzheimer's disease.
Claim 18
Dependent Claim
11 words
The method of claim 9, wherein said patient is a human.
Claim 19
Independent Claim
63 words
A method of reducing toxic injury to central neurons associated with ischemia, hypoxia, hypoglycemia, epilepsy, Huntington's disease, or Alzheimer's disease, which comprises: administering to a patient susceptible to said toxic injury an amount, sufficient to reduce said injury, of a compound selected from the group consisting of (1) analgesic opioid agonists and antagonists and (2) mirror-image enantiomers of analgesic opioid agonists and antagonists.
Claim 20
Independent Claim
63 words
A method of reducing toxic injury to central neurons associated with ischemia, hypoxia, hypoglycemia, epilepsy, Huntington's disease, or Alzheimer's disease, which comprises: administering to a patient susceptible to said toxic injury an amount, sufficient to reduce said injury, of a compound selected from the group consisting of (1) analgesic opioid agonists and antagonists and (2) mirror-image enantiomers of analgesic opioid agonists and antagonists.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1992-02-21 | 1992-08-22 | 1993-02-21 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-02-21 | 1996-08-22 | 1997-02-21 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-02-21 | 2000-08-22 | 2001-02-21 | $7700.00 | Window Closed / Lapsed |