Patent US2458766A successfully refreshed from Google Patents.
Patent US5012809A successfully refreshed from Google Patents.
US5012809A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Fiber optic catheter system with fluorometric sensor and integral flexure compensation
Assignee: Individual
•
Filing: 1986-10-10
•
Granted: 1991-05-07
•
Expires: 2006-10-10
Abstract
Abstract A sensor for measuring fluid concentrations or the temperature of body. A fiber-optic catheter having a fluorometric sensor attached at a distal end is excited by a light source outside the body. The sensor fluoresces with an intensity or with a lifetime related to the concentration of the fluid or the temperature. The catheter has one light pipe for exciting the sensor and a second light pipe for generating a reference signal to calibrate signals from the fluorometric sensor. One embodiment has two sensors that fluoresce with different intensities and lifetimes to simultaneously give information about both the temperature and the fluid concentration.
Inventors
- 👤 John E. Shulze
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 10:01
CPC Classifications
G; G02; G02B; G02B6/00; G02B6/24; G02B6/26; G02B6/28; G02B6/2804; A; A61; A61B; A61B5/00; A61B5/145; A61B5/1455; A61B5/1459; G01; G01D; G01D5/00; G01D5/26; G01D5/268; G01K; G01K11/00; G01K11/32; G01K11/3206; G01K11/3213; G01N; G01N21/00; G01N21/75; G01N21/77; G01N21/7703; G02B6/42; G02B6/4201; G02B6/4204; G02B6/421; G02B6/4298; G01N2021/7769; G01N2021/7786
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
200 words
A fluorometric sensor for measuring oxygen concentration in a body fluid comprising: a means for emitting excited light in which at least one wavelength emitted is in the upper visible-long ultraviolet light spectrum; an elongated fiber-optic equipped catheter having a distally positioned fluorometric sensor comprising a silicone copolymer matrix and a fluophor formed by dissolving into a silicone copolymer an amount of about 0.1% to 3% by weight of the fluophor selected from the group consisting of parylene dibutyrate, tris (4,7-diphenyl-1,10 phenanthroline) ruthenium II, tris (disulphonated 4,7-diphenyl-1,10 phenanthroline) ruthenium II, and tris (bipyridine) ruthenium II, in order for the fluophor to emit a fluorescent signal in response to the excited light transmitted from a proximal end of the catheter and the fluorescent signal having an intensity that is quenched by oxygen permeating from the body fluid into the silicone copolymer matrix, and wherein the silicone copolymer is selected from the group consisting of silicone polycarbonate copolymer and silicone polystyrene copolymer; and means for measuring the intensity of the fluorescent signal from the fluorometric sensor transmitted back to the proximal end of the catheter and for correlating the intensity of the fluorescent signal to the oxygen concentration in the body fluid.
Claim 2
Dependent Claim
200 words
A fluorometric sensor for measuring oxygen concentration in a body fluid comprising: a means for emitting excited light in which at least one wavelength emitted is in the upper visible-long ultraviolet light spectrum; an elongated fiber-optic equipped catheter having a distally positioned fluorometric sensor comprising a silicone copolymer matrix and a fluophor formed by dissolving into a silicone copolymer an amount of about 0.1% to 3% by weight of the fluophor selected from the group consisting of parylene dibutyrate, tris (4,7-diphenyl-1,10 phenanthroline) ruthenium II, tris (disulphonated 4,7-diphenyl-1,10 phenanthroline) ruthenium II, and tris (bipyridine) ruthenium II, in order for the fluophor to emit a fluorescent signal in response to the excited light transmitted from a proximal end of the catheter and the fluorescent signal having an intensity that is quenched by oxygen permeating from the body fluid into the silicone copolymer matrix, and wherein the silicone copolymer is selected from the group consisting of silicone polycarbonate copolymer and silicone polystyrene copolymer; and means for measuring the intensity of the fluorescent signal from the fluorometric sensor transmitted back to the proximal end of the catheter and for correlating the intensity of the fluorescent signal to the oxygen concentration in the body fluid.
Claim 3
Dependent Claim
171 words
A fluorometric sensor for measuring oxygen concentration in a body fluid comprising: light excitation means emitting excitation light having at least one wavelength in the upper visible-long ultraviolet light spectrum; an elongated fiber-optic equipped catheter including a distally positioned fluorometric sensor comprising a silicone polycarbonate copolymer and an amount of about 0.5% to 1% by weight of a fluophor dissolved into the silicone polycarbonate copolymer that emits a fluorescent signal in response to the excitation light transmitted from a proximal end of the catheter and having an intensity that is quenched by oxygen permeating from the body fluid into the silicone polycarbonate copolymer, and wherein the fluophor is selected from the group consisting of parylene dibutyrate, tris(4,7-diphenyl-1,10 phenanthroline) ruthenium II, tris (disulphonated 4,7-diphenyl-1,10 phenanthroline) ruthenium II, and tris (bipyridine) ruthenium II; and means for measuring the intensity of the fluorescent signal from the fluorometric sensor transmitted back to the proximal end of the catheter and for correlating the intensity of the fluorescent signal to the oxygen concentration in the body fluid.
Claim 4
Dependent Claim
171 words
A fluorometric sensor for measuring oxygen concentration in a body fluid comprising: light excitation means emitting excitation light having at least one wavelength in the upper visible-long ultraviolet light spectrum; an elongated fiber-optic equipped catheter including a distally positioned fluorometric sensor comprising a silicone polycarbonate copolymer and an amount of about 0.5% to 1% by weight of a fluophor dissolved into the silicone polycarbonate copolymer that emits a fluorescent signal in response to the excitation light transmitted from a proximal end of the catheter and having an intensity that is quenched by oxygen permeating from the body fluid into the silicone polycarbonate copolymer, and wherein the fluophor is selected from the group consisting of parylene dibutyrate, tris(4,7-diphenyl-1,10 phenanthroline) ruthenium II, tris (disulphonated 4,7-diphenyl-1,10 phenanthroline) ruthenium II, and tris (bipyridine) ruthenium II; and means for measuring the intensity of the fluorescent signal from the fluorometric sensor transmitted back to the proximal end of the catheter and for correlating the intensity of the fluorescent signal to the oxygen concentration in the body fluid.
Claim 5
Dependent Claim
173 words
A fluorometric sensor for measuring oxygen concentration in a body fluid comprising: light excitation means emitting excitation light having at least one wavelength in the upper visible-long ultraviolet light spectrum; an elongated fiber-optic equipped catheter including a distally positioned fluorometric sensor comprising a silicone-polystyrene copolymer and an amount of about 0.1% to 3% by weight of a fluophor dissolved into the silicone polystyrene copolymer that emits a fluorescent signal in response to the excitation light transmitted from a proximal end of the catheter and having an intensity that is quenched by oxygen permeating from the body fluid into the silicone polystyrene, and wherein the fluophor is selected from the group consisting of parylene dibutyrate, tris (4,7-diphenyl 1,10 phenanthroline) ruthenium II, tris disulphonated 4,7 diphenyl 1,10 phenanthroline ruthenium II, and tris (bipyridine) ruthenium II; and means for measuring the intensity of the fluorescent signal from the fluorometric sensor transmitted back to the proximal end of the catheter and for correlating the intensity of the fluorescent signal to the oxygen concentration in the body fluid.
Claim 6
Dependent Claim
173 words
A fluorometric sensor for measuring oxygen concentration in a body fluid comprising: light excitation means emitting excitation light having at least one wavelength in the upper visible-long ultraviolet light spectrum; an elongated fiber-optic equipped catheter including a distally positioned fluorometric sensor comprising a silicone-polystyrene copolymer and an amount of about 0.1% to 3% by weight of a fluophor dissolved into the silicone polystyrene copolymer that emits a fluorescent signal in response to the excitation light transmitted from a proximal end of the catheter and having an intensity that is quenched by oxygen permeating from the body fluid into the silicone polystyrene, and wherein the fluophor is selected from the group consisting of parylene dibutyrate, tris (4,7-diphenyl 1,10 phenanthroline) ruthenium II, tris disulphonated 4,7 diphenyl 1,10 phenanthroline ruthenium II, and tris (bipyridine) ruthenium II; and means for measuring the intensity of the fluorescent signal from the fluorometric sensor transmitted back to the proximal end of the catheter and for correlating the intensity of the fluorescent signal to the oxygen concentration in the body fluid.
References Cited (Backward Citations)
USRE31879E
Cited
US4178917A
Cited
US4476870A
Cited
US4557900A
Cited
US4487206A
Cited
GB2132348A
Cited
US4675529A
Cited
US4752115A
Cited
US4810655A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1994-05-06 | 1994-11-05 | 1995-05-07 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1998-05-06 | 1998-11-05 | 1999-05-07 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2002-05-06 | 2002-11-05 | 2003-05-07 | $7700.00 | Window Closed / Lapsed |