US5011913A
Expired / Lapsed
US
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Diphosphonate-derivatized macromolecules
Assignee: Procter and Gamble Co
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Filing: 1989-05-11
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Granted: 1991-04-30
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Expires: 2009-05-11
Abstract
Abstract Diphosphonate-derivatized macromolecules, such as proteins, suitable for use as technetium-99m-based scanning agents and as anticalcification agents are disclosed. The scanning agents are prepared by combining Tc-99m in a +3, +4 and/or +5 oxidation state with the diphosphonate-derivatized macromoleules. Also disclosed are pharmaceutical compositions containing these diphosphonate-derivatized macromolecules and methods for scintigraphic imaging using these diphosphonate-derivatized macromolecules labeled with Tc-99m.
Inventors
- 👤 James J. Benedict
- 👤 Charles R. Degenhardt
- 👤 James W. Poser
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-29 17:18
CPC Classifications
A; A61; A61K; A61K51/00; A61K51/02; A61K51/04; A61K51/06; A61K51/065; A61K41/00; A61K47/00; A61K47/50; A61K47/51; A61K47/56; A61K47/58; A61K47/61; A61K47/62; A61K47/68; A61K47/6835; A61K47/6883; A61K51/0497; A61K51/08; A61K51/10; A61K51/1093; C; C08; C08B; C08B37/00; C08B37/0006; C08B37/0036; C08B37/0039; C08F; C08F8/00; C08F8/40; C08H; C08H1/00; A61K2123/00
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
133 words
Diphosphonate-derivatized macromolecules of the formula wherein Z is a macromolecule selected from the group consisting of proteins and polypestides and further contains one or more reactive end groups selected from the group consisting of --NH 2 , --COOH, --SH, CHO, --S--S, --OH, phenol, guanidino, imidazole or indole, and mixtures thereof; L is a linking moiety selected from the group consisting of ##STR42## Q is a spacing group selected from the group consisting of C 1 -C 12 alkyl substituted aryl, unsubstituted aryl or C 1 to C 12 alkyl, where n is 0 or 1; and X is selected from the group consisting of H, OH, NH 2 , C 1 -C 12 alkyl substituted or unsubstituted amino, halogen or C 1 -C 4 alkyl; and the pharmaceutically-acceptable salts of these derivatized macromolecules.
Claim 2
Dependent Claim
133 words
Diphosphonate-derivatized macromolecules of the formula wherein Z is a macromolecule selected from the group consisting of proteins and polypestides and further contains one or more reactive end groups selected from the group consisting of --NH 2 , --COOH, --SH, CHO, --S--S, --OH, phenol, guanidino, imidazole or indole, and mixtures thereof; L is a linking moiety selected from the group consisting of ##STR42## Q is a spacing group selected from the group consisting of C 1 -C 12 alkyl substituted aryl, unsubstituted aryl or C 1 to C 12 alkyl, where n is 0 or 1; and X is selected from the group consisting of H, OH, NH 2 , C 1 -C 12 alkyl substituted or unsubstituted amino, halogen or C 1 -C 4 alkyl; and the pharmaceutically-acceptable salts of these derivatized macromolecules.
Claim 3
Dependent Claim
16 words
The diphosphonate-derivatized macromolecules according to claim 1 wherein said protein is an antibody or antibody fragment.
Claim 4
Dependent Claim
19 words
The diphosphonate-derivatized macromolecules according to claim 1 wherein said linking moiety is selected from the group consisting of ##STR43##
Claim 5
Dependent Claim
15 words
The diphosphonate-derivatized macromolecules according to claim 3 wherein said spacing group is an unsubstituted aryl.
Claim 6
Dependent Claim
22 words
The diphosphonate-derivatized macromolecules according to claim 4 wherein X is selected from the group consisting of H, OH or NH 2 .
Claim 7
Dependent Claim
39 words
The diphosphonate-derivatized macromolecules according to claim 1 selected from the group consisting of ##STR44## wherein n is an integer from 0 to about 12; and X is selected from the group consisting of H, OH and NH 2 .
References Cited (Backward Citations)
US4337240A
Cited
US4421735A
Cited
US4472509A
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US4693884A
Cited
US4707440A
Cited
US4839467A
Cited
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