US5010055A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Use of EGF to reverse the contraceptive activity of MIS
Assignee: General Hospital Corp
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Filing: 1987-06-24
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Granted: 1991-04-23
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Expires: 2007-06-24
Abstract
Abstract The invention discloses a novel use of Mullerian Inhibiting Substance (MIS) as a contraceptive agent. MIS has been found to reversably inhibit the maturation of oocytes in vitro. Additionally, the invention provides a means for restoring the fertility of females who are infertile due to abnormal production of MIS.
Inventors
- 👤 Patricia K. Donahoe
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 22:44
CPC Classifications
A; A61; A61K; A61K38/00; A61K38/16; A61K38/17; A61K38/22; A61K38/18; A61K38/1808; C; C07; C07K; C07K16/00; C07K16/18; C07K16/26
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
40 words
A method for reversing the contraceptive activity of Mullerian Inhibiting Substance which comprises providing to a female recipient of Mullerian Inhibiting Substance an Epidermal Growth Factor capable of reversing said contraceptive activity in an amount sufficient to achieve said reversal.
Claim 2
Independent Claim
40 words
A method for reversing the contraceptive activity of Mullerian Inhibiting Substance which comprises providing to a female recipient of Mullerian Inhibiting Substance an Epidermal Growth Factor capable of reversing said contraceptive activity in an amount sufficient to achieve said reversal.
Claim 3
Independent Claim
88 words
A method for controlling the fertility of a female which comprises: (a) providing an initial amount of Mullerian Inhibiting Substance to a female sufficient to induce a condition of infertility in said female, (b) maintaining said condition of infertility for a desired period of time by providing an additional amount of Mullerian Inhibiting Substance to said female, and (c) when desired, providing an Epidermal Growth Factor of reversing the condition of infertility induced by said Mullerian Inhibiting Substance in an amount sufficient to induce a condition of fertility.
Claim 4
Independent Claim
88 words
A method for controlling the fertility of a female which comprises: (a) providing an initial amount of Mullerian Inhibiting Substance to a female sufficient to induce a condition of infertility in said female, (b) maintaining said condition of infertility for a desired period of time by providing an additional amount of Mullerian Inhibiting Substance to said female, and (c) when desired, providing an Epidermal Growth Factor of reversing the condition of infertility induced by said Mullerian Inhibiting Substance in an amount sufficient to induce a condition of fertility.
Claim 5
Dependent Claim
21 words
The method of claim 2 wherein said additional amount of Mullerian Inhibiting substance is provided to said female as a bolus.
Claim 6
Dependent Claim
20 words
The method of claim 2 wherein said additional amount of Mullerian Inhibiting substance is provided as a sustained release medicament.
References Cited (Backward Citations)
US4792601A
Cited
US4753794A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1994-04-22 | 1994-10-22 | 1995-04-23 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1998-04-22 | 1998-10-22 | 1999-04-23 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2002-04-22 | 2002-10-22 | 2003-04-23 | $7700.00 | Window Closed / Lapsed |