US5009897A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Pharmaceutical granules and tablets made therefrom
Assignee: Abbott Laboratories
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Filing: 1990-07-12
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Granted: 1991-04-23
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Expires: 2010-07-12
Abstract
Abstract A pharmaceutical granule comprising a core of active pharmaceutical agent and a coating of a polymer/microcrystalline cellulose is provided. These granules permit superior tableting of pharmaceutical agents whose physical properties in granule form render them unsuitable for conventional tableting.
Inventors
- 👤 Dale R. Brinker
- 👤 Thomas L. Reiland
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-02 17:50
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/20; A61K9/2072; A61K9/2077; A61K9/2081; A61K9/48; A61K9/50; A61K9/5073
Claims Analysis
Total Claims: 14
Claim 1
Independent Claim
59 words
A granule for compression into tablets having a hardness sufficient to produce a cohesive tablet that will not fracture during tablet coating, comprising a core of active drug and a surface coating comprising a polymer selected from povidone, hydroxypropyl cellulose and hydroxypropyl methylcellulose and microcrystalline cellulose, the polymer:microcrystalline cellulose ratio being from about 1:15 to about 2:1 by weight.
Claim 2
Dependent Claim
59 words
A granule for compression into tablets having a hardness sufficient to produce a cohesive tablet that will not fracture during tablet coating, comprising a core of active drug and a surface coating comprising a polymer selected from povidone, hydroxypropyl cellulose and hydroxypropyl methylcellulose and microcrystalline cellulose, the polymer:microcrystalline cellulose ratio being from about 1:15 to about 2:1 by weight.
Claim 3
Dependent Claim
12 words
The granule of claim 1 wherein the active drug is divalproex sodium.
Claim 4
Dependent Claim
27 words
A tablet having a hardness sufficient to produce a cohesive tablet that will not fracture during tablet coating comprising granules according to claim 1 and tableting excipients.
Claim 5
Dependent Claim
12 words
The tablet of claim 3 wherein the active drug is divalproex sodium.
Claim 6
Dependent Claim
18 words
The tablet of claim 3 wherein the surface coating comprises 1% (w/v) polyvinylpyrrolidone and 10% (w/v) microcrystalline cellulose.
Claim 7
Dependent Claim
11 words
The granule of claim 1 wherein the active drug is erythromycin.
Claim 8
Dependent Claim
11 words
The tablet of claim 3 wherein the active drug is erythromycin.
Claim 9
Dependent Claim
45 words
A granule for compression into tablets having a hardness sufficient to produce a cohesive tablet that will not fracture during tablet coating, comprising a core of divalproex sodium and a surface coating comprising polyvinylpyrrolidone and microcrystalline cellulose in a ratio of about 1:10 by weight.
Claim 10
Dependent Claim
45 words
A granule for compression into tablets having a hardness sufficient to produce a cohesive tablet that will not fracture during tablet coating, comprising a core of divalproex sodium and a surface coating comprising polyvinylpyrrolidone and microcrystalline cellulose in a ratio of about 1:10 by weight.
Claim 11
Dependent Claim
29 words
A tablet having a hardness sufficient to produce a cohesive tablet that will not fracture during tablet coating and comprising drug granules according to claim 8 and tableting excipients.
Claim 12
Dependent Claim
47 words
A granule for compression into tablets having a hardness sufficient to produce a cohesive tablet that will not fracture during tablet coating comprising a core of erythromycin and a surface coating comprising hydroxypropyl methylcellulose, hydroxypropyl cellulose and microcrystalline cellulose in a ratio of about 1:1:5 by weight.
Claim 13
Dependent Claim
47 words
A granule for compression into tablets having a hardness sufficient to produce a cohesive tablet that will not fracture during tablet coating comprising a core of erythromycin and a surface coating comprising hydroxypropyl methylcellulose, hydroxypropyl cellulose and microcrystalline cellulose in a ratio of about 1:1:5 by weight.
Claim 14
Dependent Claim
29 words
A tablet having a hardness sufficient to produce a cohesive tablet that will not fracture during tablet coating and comprising drug granules according to claim 10 and tableting excipients.
References Cited (Backward Citations)
GB1598458A
Cited
FR2392677A1
Cited
US4533674A
Cited
US4555399A
Cited
WO1986004817A1
Cited
EP0196546A2
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1994-04-22 | 1994-10-22 | 1995-04-23 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1998-04-22 | 1998-10-22 | 1999-04-23 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2002-04-22 | 2002-10-22 | 2003-04-23 | $7700.00 | Window Closed / Lapsed |