US5009894A
Expired / Lapsed
US
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Arrangement for and method of administering a pharmaceutical preparation
Assignee: Teva Branded Pharmaceutical Products R&D Inc
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Filing: 1988-03-07
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Granted: 1991-04-23
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Expires: 2008-03-07
Abstract
Abstract A multitude of non-tacky coated pellets containing a pharmaceutical preparation is housed within a breakable packet which, when broken, enables ready removal of the pellets for the oral administration of the preparation to a patient. The packet includes a bendable backing sheet and a fracturable covering member between which the pellets are held in a vacuum-sealed environment prior to use. The coating of the pellets also prevents dissolution of the preparation in the mouth to avoid the sensation of bitter medicinal taste.
Inventors
- 👤 Charles Hsiao
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-31 17:48
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/48; A61K9/50; A61K9/5005; A61K9/5021; A61K9/5026; B; B65; B65D; B65D75/00; B65D75/52; B65D75/58; B65D75/5827; B65D75/585; B65D2221/00
Claims Analysis
Total Claims: 23
Claim 1
Independent Claim
193 words
An arrangement for administering a pharmaceutical preparation, comprising: a multitude of pellets containing a pharmaceutical preparation and having non-tacky coatings; and a breakable packet including a backing sheet having opposite major planar surfaces, and a covering member overlying the backing sheet, and extending outwardly of, and having a flange portion sealed to one of said major surfaces, said covering member bounding with the backing sheet a compartment in which the pellets are contained, said covering member including a hollow main portion having a predetermined half-cylindrical cross-section and extending along a longitudinal direction, a neck portion having a half-frusto-conical cross-section less than said predetermined cross-section and tapered walls which converge toward each other along the longitudinal direction to a waist, and a head portion having a half-spherical cross-section and tapered walls which diverge apart along the longitudinal direction away from the waist, said covering member having its smallest dimension, as considered along a transverse direction generally perpendicular to the longitudinal direction, at the waist, said packet having across the waist a frangible zone which, when broken, forms the neck portion as a tapered pouring spout through which the pellets are poured from the compartment.
Claim 2
Dependent Claim
193 words
An arrangement for administering a pharmaceutical preparation, comprising: a multitude of pellets containing a pharmaceutical preparation and having non-tacky coatings; and a breakable packet including a backing sheet having opposite major planar surfaces, and a covering member overlying the backing sheet, and extending outwardly of, and having a flange portion sealed to one of said major surfaces, said covering member bounding with the backing sheet a compartment in which the pellets are contained, said covering member including a hollow main portion having a predetermined half-cylindrical cross-section and extending along a longitudinal direction, a neck portion having a half-frusto-conical cross-section less than said predetermined cross-section and tapered walls which converge toward each other along the longitudinal direction to a waist, and a head portion having a half-spherical cross-section and tapered walls which diverge apart along the longitudinal direction away from the waist, said covering member having its smallest dimension, as considered along a transverse direction generally perpendicular to the longitudinal direction, at the waist, said packet having across the waist a frangible zone which, when broken, forms the neck portion as a tapered pouring spout through which the pellets are poured from the compartment.
Claim 3
Dependent Claim
34 words
The arrangement as recited in claim 1, wherein the covering member has a predetermined degree of frangibility, and wherein the backing sheet has a degree of frangibility less than said predetermined degree of frangibility.
Claim 4
Dependent Claim
34 words
The arrangement as recited in claim 2, wherein the backing sheet is constituted of a paper material coated with plastic or aluminum, and wherein the covering member is constituted of a synthetic plastic material.
Claim 5
Dependent Claim
22 words
The arrangement as recited in claim 1, wherein the pharmaceutical preparation comprises an active ingredient and pharmaceutically acceptable binders, fillers or excipients.
Claim 6
Dependent Claim
14 words
The arrangement as recited in claim 4, wherein said active ingredient is orally active.
Claim 7
Dependent Claim
38 words
The arrangement as recited in claim 1, wherein the backing sheet is bendable when subjected to external forces at the waist, and wherein the covering member fractures at the waist when said external forces bend the backing sheet.
Claim 8
Dependent Claim
40 words
The arrangement as recited in claim 6, wherein the covering member fractures into fractured parts which remain attached to the bent backing sheet, one fractured part being the head portion, and another fractured part being the main and neck portions.
Claim 9
Dependent Claim
42 words
The arrangement as recited in claim 5, wherein said orally active ingredient is selected from the group consisting of analgesics, antiasthmatics, anti-microbials, antibacterials, antibiotics, antifungal agents, antihistamines, anti-inflammatory agents, antiepileptic agents, cough and cold medicines, cardiovascular agents, diuretics, laxatives, tranquilizers, and vitamins.
Claim 10
Dependent Claim
27 words
The arrangement as recited in claim 1, wherein the covering member is constituted of a light-transmissive material to permit viewing of the pellets through the covering member.
Claim 11
Dependent Claim
24 words
The arrangement as recited in claim 1, wherein the packet includes indicia applied onto the other of said major surfaces of the backing sheet.
Claim 12
Dependent Claim
28 words
The arrangement as recited in claim 1; and further comprising another covering member overlying the backing sheet and bounding therewith another compartment in which additional pellets are contained.
Claim 13
Dependent Claim
28 words
The arrangement as recited in claim 1, wherein each pellet has a diameter not greater than 1 mm, said pellets being freely accommodated with clearance in the compartment.
Claim 14
Dependent Claim
15 words
The arrangement as recited in claim 1, wherein each non-tacky coating includes a polymeric material.
Claim 15
Dependent Claim
22 words
The arrangement as recited in claim 13, wherein each non-tacky coating further includes a basic compound filler that is soluble in acid.
Claim 16
Dependent Claim
25 words
The arrangement as recited in claim 13, wherein the polymeric material includes a cationic copolymeric acrylate resin based on methacrylate and neutral methacrylic acid esters.
Claim 17
Dependent Claim
26 words
The arrangement as recited in claim 14, wherein the basic compound filler is selected from the group consisting of calcium carbonate, aluminum hydroxide and magnesium carbonate.
Claim 18
Dependent Claim
28 words
The arrangement as recited in claim 14, wherein the basic compound filler is present in the coating in an amount from about 10% to about 90% by weight.
Claim 19
Dependent Claim
23 words
The arrangement as recited in claim 13, wherein the polymeric material is selected from the group consisting of cellulosic, polyacrylate and polyvinyl-alcoholic polymers.
Claim 20
Dependent Claim
28 words
The arrangement as recited in claim 1, wherein the pharmaceutical preparation contained in the pellets is a fraction of a dose to be administered to a human patient.
Claim 21
Dependent Claim
28 words
The arrangement as recited in claim 1, wherein the pharmaceutical preparation contained in the pellets is a multiple of a dose to be administered to a human patient.
Claim 22
Independent Claim
205 words
A method of administering an orally active pharmaceutical preparation to a patient, comprising the steps of: (a) breaking open a frangible packet having a backing sheet having opposite major planar surfaces, and a covering member overlying the backing sheet, and extending outwardly of, and having a flange portion sealed to one of said major surfaces, said covering member bounding with the backing sheet a compartment, said compartment housing non-tacky coated pellets containing the preparation, said covering member including a hollow main portion having a predetermined half-cylindrical cross-section and extending along a longitudinal direction, a neck portion having a half-frusto-conical cross section less than said predetermined cross-section and tapered wall which converge toward each other along the longitudinal direction to a waist, and a head portion having a half-spherical cross-section and tapered walls which diverge apart along the longitudinal direction away from the waist, said covering member having its smallest dimension, as considered along a transverse direction generally perpendicular to the longitudinal direction, at the waist, said breaking open step being performed by breaking the packet across the waist to form the neck portion as a tapered pouring spout; and (b) pouring the pellets from the tapered pouring spout into a human or animal patient's mouth.
Claim 23
Independent Claim
205 words
A method of administering an orally active pharmaceutical preparation to a patient, comprising the steps of: (a) breaking open a frangible packet having a backing sheet having opposite major planar surfaces, and a covering member overlying the backing sheet, and extending outwardly of, and having a flange portion sealed to one of said major surfaces, said covering member bounding with the backing sheet a compartment, said compartment housing non-tacky coated pellets containing the preparation, said covering member including a hollow main portion having a predetermined half-cylindrical cross-section and extending along a longitudinal direction, a neck portion having a half-frusto-conical cross section less than said predetermined cross-section and tapered wall which converge toward each other along the longitudinal direction to a waist, and a head portion having a half-spherical cross-section and tapered walls which diverge apart along the longitudinal direction away from the waist, said covering member having its smallest dimension, as considered along a transverse direction generally perpendicular to the longitudinal direction, at the waist, said breaking open step being performed by breaking the packet across the waist to form the neck portion as a tapered pouring spout; and (b) pouring the pellets from the tapered pouring spout into a human or animal patient's mouth.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1994-04-22 | 1994-10-22 | 1995-04-23 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1998-04-22 | 1998-10-22 | 1999-04-23 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2002-04-22 | 2002-10-22 | 2003-04-23 | $7700.00 | Window Closed / Lapsed |