Patent US5006313A successfully refreshed from Google Patents.
US5006313A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Halogenated surface with reduced protein interaction
Assignee: Agilent Technologies Inc
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Filing: 1988-06-02
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Granted: 1991-04-09
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Expires: 2008-06-02
Abstract
Abstract A method for treating a solid surface exposable to protein solutes is provided that reduces interactions of the protein solutes with the surface. Thus, a small bore capillary tube, useful for electrophoretic separation, comprises a reduced interaction phase coated along the bore that includes a terminal moiety covalently bound in the reduced interaction phase through at least one heteroatom. This terminal moiety includes a plurality of halogen atoms, and preferably is an aryl pentafluoro.
Inventors
- 👤 Sally A. Swedberg
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-04 08:51
CPC Classifications
G; G01; G01N; G01N27/00; G01N27/26; G01N27/416; G01N27/447; G01N27/44704
Claims Analysis
Total Claims: 5
Claim 1
Independent Claim
78 words
A device for electrophoretic separations of protein solutes, comprising: a small bore capillary tube having a reduced interaction phase coated along the bore and effective to reduce interaction between protein solute and the bore, the reduced interaction phase including a terminal moiety covalently bound in the reduced interaction phase through at least one heteroatom, the at least one heteroatom forming a linkage intermediate the bore and the terminal moiety, the terminal moiety including a plurality of halogen atoms.
Claim 2
Independent Claim
78 words
A device for electrophoretic separations of protein solutes, comprising: a small bore capillary tube having a reduced interaction phase coated along the bore and effective to reduce interaction between protein solute and the bore, the reduced interaction phase including a terminal moiety covalently bound in the reduced interaction phase through at least one heteroatom, the at least one heteroatom forming a linkage intermediate the bore and the terminal moiety, the terminal moiety including a plurality of halogen atoms.
Claim 3
Dependent Claim
35 words
The capillary tube as in claim 1 wherein the at least one heteroatom is one or more of nitrogen, oxygen or sulfur and the at least one heteroatom increases hydrophilicity of the reduced interaction phase.
Claim 4
Dependent Claim
31 words
The capillary tube as in claim 1 wherein the terminal moiety is a plurality of halogen atoms that are substituents on an aryl group, an alkylaryl group or an alkyl group.
Claim 5
Dependent Claim
16 words
The capillary tube as in claim 1 wherein the terminal moiety is an aryl pentahalo group.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1994-04-08 | 1994-10-08 | 1995-04-09 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1998-04-08 | 1998-10-08 | 1999-04-09 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2002-04-08 | 2002-10-08 | 2003-04-09 | $7700.00 | Window Closed / Lapsed |