Patent US3213305A successfully refreshed from Google Patents.
Patent US4999342A successfully refreshed from Google Patents.
US4999342A
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US
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Long lasting contraceptive suppository composition and methods of use
Assignee: Ortho Pharmaceutical Corp
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Filing: 1988-08-16
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Granted: 1991-03-12
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Expires: 2008-08-16
Abstract
Abstract Compositions and methods for providing long lasting contraceptive protection comprising a mixture of a contraceptive effective amount of spermicidal agent, a polymeric gum, a dispersing agent, and a water miscible polyethylene glycol polymer suppository base; and mammalian contraceptive methods utilizing the compositions of the invention in suppository form to provide up to 12 hours of contraceptive protection after initial insertion of the suppository.
Inventors
- 👤 Nawaz Ahmad
- 👤 George A. Ziets
- 👤 Sudeb Das
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-06 12:58
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/0012; A61K9/0034; Y; Y10; Y10S; Y10S424/00; Y10S424/14; Y10S424/15
Claims Analysis
Total Claims: 18
Claim 1
Independent Claim
34 words
A long lasting viscous adhesive contraceptive suppository composition comprising a mixture of a contraceptive effective amount of spermicidal agent; a polymeric gum; a dispersing agent comprising silica; and a water miscible polymer suppository base.
Claim 2
Dependent Claim
34 words
A long lasting viscous adhesive contraceptive suppository composition comprising a mixture of a contraceptive effective amount of spermicidal agent; a polymeric gum; a dispersing agent comprising silica; and a water miscible polymer suppository base.
Claim 3
Dependent Claim
22 words
A composition according to claim 1 wherein the polymeric gum is a polysaccharide gum and the water miscible polymer is polyethylene glycol.
Claim 4
Dependent Claim
21 words
A composition according to claim 1 wherein the dispersing agent is fumed silica, colloidal silicon dioxide, silica gel or mixtures thereof.
Claim 5
Dependent Claim
25 words
A composition according to claim 1 wherein the spermicidal agent is selected from the group consisting of nonoxynol-9, octoxynol-9, menfegol, benzalkonium chloride, and mixtures thereof.
Claim 6
Dependent Claim
34 words
A composition according to claim 4 wherein the polymeric gum is selected from the groups consisting of carboxymethylcellulose, xanthan gum and mixtures thereof; and the dispersing agent is fumed silica or colloidal silicon dioxide.
Claim 7
Dependent Claim
63 words
A long lasting contraceptive suppository composition comprising a component mixture of from about 10 to about 30% by weight of spermicidal agent; from about 15 to about 25% by weight of polymeric gum; from about 1 to about 4.0% by weight of dispersing agent comprising silica; and from about 41% to about 74% of suppository base material comprising water miscible polyethylene glycol polymer.
Claim 8
Dependent Claim
63 words
A long lasting contraceptive suppository composition comprising a component mixture of from about 10 to about 30% by weight of spermicidal agent; from about 15 to about 25% by weight of polymeric gum; from about 1 to about 4.0% by weight of dispersing agent comprising silica; and from about 41% to about 74% of suppository base material comprising water miscible polyethylene glycol polymer.
Claim 9
Dependent Claim
67 words
A composition according to claim 6 wherein the spermicidal agent is selected from the group consisting of nonoxynol-9, octoxynol-9, menfegol and mixtures thereof; the polymeric gum is selected from the group consisting of carboxymethylcellulose, xanthan gum and mixtures thereof; the dispersing agent is fumed silica or silica gel; and the water miscible polyethylene glycol is a mixture of polymers having molecular weights of from 200 to 6000.
Claim 10
Dependent Claim
44 words
A composition according to claim 7 wherein the polymeric gum component is a mixture of from 60 to 85% of carboxymethylcellulose and 15 to 40% of xanthan gum by weight; and the dispersing agent is from 1.5 to 4.0% by weight of fumed silica.
Claim 11
Dependent Claim
12 words
A composition according to claim 7 wherein the spermicidal agent is nonoxynol-9.
Claim 12
Dependent Claim
99 words
A long lasting mammalian contraceptive method comprising the steps of inserting a suppository composition comprising a component mixture of a contraceptive effective amount of spermicidal agent, a sufficient amount of polymeric gum to induce viscous adhesive qualities to said spermicidal agent, a sufficient amount of dispersing agent to provide homogenous melt characteristics to the suppository composition, and a water miscible polymer suppository base, into the vicinity of the cervix in a vagina of a warm blooded mammal prior to coitus; and engaging therewith in an act of coitus up to over 5 hours after insertion of the suppository compositions.
Claim 13
Dependent Claim
99 words
A long lasting mammalian contraceptive method comprising the steps of inserting a suppository composition comprising a component mixture of a contraceptive effective amount of spermicidal agent, a sufficient amount of polymeric gum to induce viscous adhesive qualities to said spermicidal agent, a sufficient amount of dispersing agent to provide homogenous melt characteristics to the suppository composition, and a water miscible polymer suppository base, into the vicinity of the cervix in a vagina of a warm blooded mammal prior to coitus; and engaging therewith in an act of coitus up to over 5 hours after insertion of the suppository compositions.
Claim 14
Dependent Claim
38 words
The method according to claim 10 wherein the act of coitus is engaged in a time period of from 10 minutes up to 12 hours after insertion of the suppository composition and the suppository base is polyethylene glycol.
Claim 15
Dependent Claim
71 words
The method according to claim 11 wherein the spermicidal agent is selected from the group consisting of nonoxynol-9, octoxynol-9, menfegol, benzalkonium chloride and mixtures thereof; the polymeric gum is selected from the group consisting of carboxymethylcullulose, xanthan gum and mixtures thereof; the dispersing agent is fumed silica or silica gel; and the polyethylene glycol polymer is a mixture of polyethylene glycol having a molecular weight range of between 200 and 6000.
Claim 16
Dependent Claim
30 words
The method according to claim 10 wherein the spermicidal agent is nonoxynol-9; the polymeric gum is a mixture of carboxymethylcellulose and xanthan gum; and the dispersing agent is fumed silica.
Claim 17
Dependent Claim
57 words
The method according to claim 10 wherein the component mixture is by weight of the total composition from about 10 to 30% of spermicidal agent, from about 15 to 25% of the polymeric gum, from about 1.0 to 5.0% by weight of the dispersing agent, and from about 41% to 74% of polyethylene glycol suppository base material.
Claim 18
Dependent Claim
45 words
The method according to claim 14 wherein the spermicidal agent is nonoxynol-9; the polymeric gum component is a mixture of from 60 to 85% of carboxymethylcellulose and from 15 to 40% of xanthan gum; and the dispersing agent is from 1.5 to 4.0% fumed silica.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 1994-03-11 | 1994-09-10 | 1995-03-12 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1998-03-11 | 1998-09-10 | 1999-03-12 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2002-03-11 | 2002-09-10 | 2003-03-12 | $7700.00 | Window Closed / Lapsed |