Abstract The invention relates to a drug system for the treatment and alleviation of the symptoms of epilepsy; as anticonvulsant agent, and for the prevention or alleviation of brain damage due to strokes. The drug system comprises as active ingredient a compound such as MK-801, phencyclidine or as thienyl-cyclohexyl-piperidine (TCP), which is administered in such a manner that it encounters and binds to the N-methyl-D-aspartate (NMDA) receptor channels. This is in the presence of glutamate or glycine, or similarly acting amino-acid, which is either present in the patient, or which can be administered separately. The effective drug can be effectively locked in the receptor channels by means of a glutamate antagonist, such as AP-5.
Inventors
👤 Mordechai Sokolovsky
👤 Yoel Kloog
Bibliographic Details
Application Number—
JurisdictionUS
Data Sourcegoogle_patents
Last Synchronized2026-11-05 14:43
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/66
Claims Analysis
Total Claims: 4
Claim 1
Independent Claim
49 words
A pharmaceutical composition for the treatment of epilepsy, for use as anticonvulsant and for the prevention of damage caused by strokes in mammals, including humans, which comprises in combination from 15 mg to 500 mg phencyclidine and from 350 mg to 1000 mg of D (-) 2-amino-5-phosphovaleric acid (AP-5).
Claim 2
Dependent Claim
49 words
A pharmaceutical composition for the treatment of epilepsy, for use as anticonvulsant and for the prevention of damage caused by strokes in mammals, including humans, which comprises in combination from 15 mg to 500 mg phencyclidine and from 350 mg to 1000 mg of D (-) 2-amino-5-phosphovaleric acid (AP-5).
Claim 3
Dependent Claim
51 words
A method for the treatment of epilepsy, for treating convulsions and for preventing the damage to the brain caused by a stroke, or at least for substantially reducing such damage, which comprises administering to the patient in need thereof a pharmacologically effective quantity of a pharmaceutical composition claimed in claim 1.
Claim 4
Dependent Claim
24 words
A method according to claim 2, where for the removal of the effective drug from the channel, there is administered an excess of glutamate.