Patent US4987181A successfully refreshed from Google Patents.
US4987181A
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US
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Substrate with an antithromogenic active surface
Assignee: Battelle Memorial Institute Inc
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Filing: 1989-09-19
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Granted: 1991-01-22
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Expires: 2009-09-19
Abstract
Abstract Copolymer film deposited on a substrate comprising covalently fixed fragments of heparin having antithrombogenic properties. The polymer further comprises free carboxylic groups intended to neutralize free amine functions which are possibly present and to improve the hemocompatibility of the film.
Inventors
- 👤 Daniel Bichon
- 👤 Christian Guillot
- 👤 Michel Schneider
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 16:27
CPC Classifications
A; A61; A61L; A61L33/00; A61L33/0005; A61L33/0011; A61L33/0029
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
74 words
Substrate having on at least a portion of its surface an adhesive film with antithrombogenic properties, characterized in that this film is constituted of an olefinic copolymer comprising, covalently bound to the main chain and distibuted rendomly thereon, free carboxylic side groups and groups of formula --CONH--(CH 2 ) n --NH--CH 2 R (I) wherein R is a heparin molecule or a depolymerization fragment thereof and n is a integer from 2 to 12.
Claim 2
Dependent Claim
74 words
Substrate having on at least a portion of its surface an adhesive film with antithrombogenic properties, characterized in that this film is constituted of an olefinic copolymer comprising, covalently bound to the main chain and distibuted rendomly thereon, free carboxylic side groups and groups of formula --CONH--(CH 2 ) n --NH--CH 2 R (I) wherein R is a heparin molecule or a depolymerization fragment thereof and n is a integer from 2 to 12.
Claim 3
Dependent Claim
36 words
Substrate according to claim 1, characterized in that the copolymer comprises segments derived from the following monomers: acrylic acid, N,N-dimethylaminoethyl methacrylate, dimethylacrylamide, and amido-acrylic derivatives in which the amide group is that represented by formula I.
Claim 4
Dependent Claim
24 words
Substrate according to claim 1, further characterized by side groups of formula --CONH--(CH 2 ) n --COOH wherein n is from 1 to 12.
Claim 5
Dependent Claim
20 words
Substrate according to claim 1, characterized in that R is a fragment issued from the HNO 2 deamination of heparin.
Claim 6
Dependent Claim
20 words
A substrate according to claim 1 in the form of a component of a surgical device for contact with blood.
Claim 7
Dependent Claim
21 words
A substrate according to claim 5 suitable for use in a surgical device selected from catheters, flexible tubings, containers or pumps.
References Cited (Backward Citations)
FR2187849A1
Cited
US3826678A
Cited
EP0086186A1
Cited
US4526714A
Cited
US4521564A
Cited
US4720512A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1994-01-21 | 1994-07-23 | 1995-01-22 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1998-01-21 | 1998-07-23 | 1999-01-22 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2002-01-21 | 2002-07-23 | 2003-01-22 | $7700.00 | Window Closed / Lapsed |