US4986271A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Vivo refillable glucose sensor
Assignee: University of New Mexico
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Filing: 1989-07-19
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Granted: 1991-01-22
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Expires: 2009-07-19
Abstract
Abstract An arrangement for prolonging the useful life of an electrochemical refillable implantable glucose sensor employing an enzyme material such as glucose oxidase immobilized on bulk particulate matter suspended in a fluid for reaction with components of bodily fluids and which enzyme material when exhausted or degraded after reaction may be replaced by fresh enzyme-loaded particles.
Inventors
- 👤 Ebtisam S. Wilkins
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-02 13:11
CPC Classifications
A; A61; A61B; A61B5/00; A61B5/145; A61B5/1468; A61B5/1486; A61B5/14865; C; C12; C12M; C12M21/00; C12M21/18; C12M23/00; C12M23/34; C12M29/00; C12M29/04; C12Q; C12Q1/00; C12Q1/001; C12Q1/005; C12Q1/006; Y; Y10; Y10S; Y10S435/00; Y10S435/817
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
94 words
The method of prolonging the useful life of an electrochemical sensor implanted in a living body and of the type employing an enzyme material for reaction with components of bodily fluids and which enzyme material becomes spent or degraded after reaction comprising the steps of: fixing the enzyme material on bulk particulate matter for reaction in the implanted sensor with a component of bodily fluids, and recharging the implanted sensor with fresh enzyme material fixed on said bulk particulate matter and removing the bulk particulate matter carrying the degraded enzyme material from the sensor.
Claim 2
Independent Claim
94 words
The method of prolonging the useful life of an electrochemical sensor implanted in a living body and of the type employing an enzyme material for reaction with components of bodily fluids and which enzyme material becomes spent or degraded after reaction comprising the steps of: fixing the enzyme material on bulk particulate matter for reaction in the implanted sensor with a component of bodily fluids, and recharging the implanted sensor with fresh enzyme material fixed on said bulk particulate matter and removing the bulk particulate matter carrying the degraded enzyme material from the sensor.
Claim 3
Dependent Claim
19 words
The method according to claim 1 wherein the bulk particulate matter is electrically conductive particles suspended in a fluid.
Claim 4
Dependent Claim
21 words
The method according to claim 2 wherein the enzyme material is glucose oxidase and the component of bodily fluids is glucose.
Claim 5
Dependent Claim
22 words
The method according to claim 1 wherein the particulate matter comprises electrically conductive particles in bulk powder form suspended in a liquid.
Claim 6
Dependent Claim
114 words
An electrochemical sensor implantable for an extended period of time in a living body for sensing one or more components of bodily fluids comprising: a housing having membrane means for defining reaction chamber means into which said one or more components of the bodily fluid may enter via said membrane means; charge flow means and discharge flow means coupled to said reaction chamber means for respectively admitting to and expelling from said reaction chamber means particulate matter containing an enzyme for chemically reacting with at least one of said components, and electrode means in said reaction chamber means for producing electrical signals corresponding to the chemical reaction between the enzyme material and the component.
Claim 7
Dependent Claim
114 words
An electrochemical sensor implantable for an extended period of time in a living body for sensing one or more components of bodily fluids comprising: a housing having membrane means for defining reaction chamber means into which said one or more components of the bodily fluid may enter via said membrane means; charge flow means and discharge flow means coupled to said reaction chamber means for respectively admitting to and expelling from said reaction chamber means particulate matter containing an enzyme for chemically reacting with at least one of said components, and electrode means in said reaction chamber means for producing electrical signals corresponding to the chemical reaction between the enzyme material and the component.
Claim 8
Dependent Claim
51 words
The sensor according to claim 5 wherein said reaction chamber means and membrane means comprises a first chamber having a first membrane for admitting bodily fluid into the first chamber and a second chamber having a second membrane for admitting a glucose component of said bodily fluid into the second chamber.
Claim 9
Dependent Claim
19 words
The sensor according to claim 6 wherein the enzyme consists essentially of glucose oxidase situated in said second chamber.
Claim 10
Dependent Claim
66 words
The sensor according to claim 7 wherein said reaction chamber means further comprises a third chamber containing a catalase enzyme material and said membrane means further comprises a third membrane for said third chamber separating said second chamber from the third chamber, whereby hydrogen peroxide resulting from the chemical reaction in said second chamber passes through said third membrane and is neutralized by said catalase enzyme.
Claim 11
Dependent Claim
16 words
The sensor according to claim 5 wherein said particulate matter is carried in a liquid suspension.
References Cited (Backward Citations)
SU446820A1
Cited
US3979274A
Cited
US4224125A
Cited
US4376689A
Cited
US4240438A
Cited
US4418148A
Cited
US4655880A
Cited
US4830713A
Cited
US4805624A
Cited
US4795542A
Cited
US4703756A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1994-01-21 | 1994-07-23 | 1995-01-22 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1998-01-21 | 1998-07-23 | 1999-01-22 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2002-01-21 | 2002-07-23 | 2003-01-22 | $7700.00 | Window Closed / Lapsed |