US4981874A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Medicaments
Assignee: Individual
•
Filing: 1989-08-15
•
Granted: 1991-01-01
•
Expires: 2009-08-15
Abstract
Abstract A method and certain compositions for treating Pneumocystis carinii infections in a mammal by administering a certain naphthoquinone compound or physiologically acceptable salts thereof.
Inventors
- 👤 Victoria S. Latter
- 👤 Winston E. Gutteridge
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-05 20:51
CPC Classifications
C; C07; C07C; C07C229/00; C07C229/52; C07C229/54; C07C229/60; A; A61; A61K; A61K31/00; A61K31/12; C07C217/00; C07C217/02; C07C217/04; C07C217/06; C07C217/12; C07C225/00; C07C225/24; C07C225/26; C07C225/30; C07C46/00; C07C50/00; C07C50/24; C07C50/26; C07C50/32; C07C69/00; C07C69/013; C07C69/017; C07C69/96; C07C2601/00; C07C2601/12; C07C2601/14; C07C2602/00; C07C2602/02; C07C2602/04; C07C2602/10; C07C2602/14; C07C2602/26; Y; Y02; Y02A; Y02A50/00; Y02A50/30
Claims Analysis
Total Claims: 24
Claim 1
Independent Claim
41 words
A method of treating a Pneumocystis carinii infection in a mammal which comprises administering to said mammal having said infection an effective Pneumocystis carinii treatment amount of a naphthoquinone of the general formula (II): ##STR3## or a physiologically acceptable salt thereof.
Claim 2
Independent Claim
41 words
A method of treating a Pneumocystis carinii infection in a mammal which comprises administering to said mammal having said infection an effective Pneumocystis carinii treatment amount of a naphthoquinone of the general formula (II): ##STR3## or a physiologically acceptable salt thereof.
Claim 3
Dependent Claim
19 words
A method according to claim 1 wherein in the compound 2-[trans-4-(4-chlorophenyl)cyclohexyl]-3-hydroxy-1,4-naphthoquinone or a physiologically acceptable salt thereof is administered.
Claim 4
Dependent Claim
36 words
A method according to claim 1 or claim 2 wherein the compound or salt of formula (II) is administered in an amount of from 10 to 50 mg per kilogram of mammal body weight per day.
Claim 5
Dependent Claim
12 words
A method according to claim 1 wherein the mammal is a human.
Claim 6
Dependent Claim
12 words
A method according to claim 2 wherein the mammal is a human.
Claim 7
Dependent Claim
13 words
A method according to claim 3 in which the mammal is a human.
Claim 8
Independent Claim
19 words
A method of claims 1, 2, 3, 4, 5 or 6 in which the mammal has an HIV infection.
Claim 9
Independent Claim
27 words
A method of treating Pneumocystis carinii infection in a mammal, which comprises administering to a mammal having said infection an effective Pneumocystis carinii treatment amount of 2-[trans-4-(4-chlorophenyl)cyclohexyl]-3-hydroxy-1,4-naphthoquinone.
Claim 10
Independent Claim
27 words
A method of treating Pneumocystis carinii infection in a mammal, which comprises administering to a mammal having said infection an effective Pneumocystis carinii treatment amount of 2-[trans-4-(4-chlorophenyl)cyclohexyl]-3-hydroxy-1,4-naphthoquinone.
Claim 11
Dependent Claim
13 words
A method according to claim 8, in which the mammal is a human.
Claim 12
Dependent Claim
24 words
A method according to claim 1, 2 or 8, wherein the compound of formula (II) or a physiologically acceptable salt thereof is administered nasally.
Claim 13
Dependent Claim
24 words
A method according to claim 1, 2 or 8, wherein the compound of formula (II) or a physiologically acceptable salt thereof is administered parenterally.
Claim 14
Dependent Claim
24 words
A method according to claim 1, 2 or 8, wherein the compound of formula (II) or a physiologically acceptable salt thereof is administered orally.
Claim 15
Dependent Claim
26 words
A method according to claim 1, 2 or 8, wherein the compound of formula (II) or a physiologically acceptable salt thereof is given by pulmonary administration.
Claim 16
Dependent Claim
16 words
A method according to claim 1, 2 or 8, wherein the infection is Pneumocystis carinii pneumonia.
Claim 17
Independent Claim
37 words
A method of preventing Pneumocystis carinii infections in an immunocompromised mammal which comprises administering to said mammal an effective P.carinii prevention amount of a naphthoquinone of the general formula (II): ##STR4## or a physiologically acceptable salt thereof.
Claim 18
Independent Claim
37 words
A method of preventing Pneumocystis carinii infections in an immunocompromised mammal which comprises administering to said mammal an effective P.carinii prevention amount of a naphthoquinone of the general formula (II): ##STR4## or a physiologically acceptable salt thereof.
Claim 19
Dependent Claim
22 words
A method according to claim 15 wherein the compound of formula (II) is 2-[trans-4-(4-chlorophenyl)cyclohexyl]-3-hydroxy-1,4-naphthoquinone or a physiologically acceptable salt thereof is administered.
Claim 20
Dependent Claim
34 words
A method according to claim 15 or claim 16 wherein the compound of formula (II) is administered in an amount of from 10 to 50 mg per kilogram of mammal body weight per day.
Claim 21
Independent Claim
20 words
The method of claims 15, 16 or 17 in which the mammal has an HIV infection and is a human.
Claim 22
Independent Claim
15 words
The method of claims 15, 16 or 17 in which the mammal is a human.
Claim 23
Independent Claim
25 words
A method of preventing Pneumocystis carinii infections in an immunocompromised mammal, which comprises administering to said mammal an effective Pneumocystis carinii prevention amount of 2-[trans-4-(4-chlorophenyl)cyclohexyl]-3-hydroxy-1,4-naphthoquinone.
Claim 24
Independent Claim
25 words
A method of preventing Pneumocystis carinii infections in an immunocompromised mammal, which comprises administering to said mammal an effective Pneumocystis carinii prevention amount of 2-[trans-4-(4-chlorophenyl)cyclohexyl]-3-hydroxy-1,4-naphthoquinone.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1993-12-31 | 1994-07-02 | 1995-01-01 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1997-12-31 | 1998-07-02 | 1999-01-01 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2001-12-31 | 2002-07-02 | 2003-01-01 | $7700.00 | Window Closed / Lapsed |