EP0123239A2
Expired / Lapsed
EP
⏱️ 0.0 years remaining
Improvements in or relating to antiprotozoal agents
Assignee: Wellcome Foundation Ltd
•
Filing: 1984-04-14
•
Granted: —
•
Expires: 2004-04-14
Abstract
Abstract Novel combinations of an antiprotozoal naphthoquinone and a 4-pyridinol or an alkanoic ester thereof wherein the antiprotozoal activity of the combination is potentiated with respectto the corresponding activity of the components ofthe combination. The combinations are especially useful for the treatment or prophylaxis of malaria.
Inventors
- 👤 Victoria Susan Latter
- 👤 Alan Thomas Hudson
- 👤 William Henry George Richards
- 👤 Anthony Winchester Randall
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-11-06 04:37
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/33; A61K31/395; A61K31/435; A61K31/44; A61P; A61P33/00; A61P33/02; Y; Y02; Y02A; Y02A50/00; Y02A50/30
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
30 words
1) A combination of an antiprotozoal naphthoquinone and a 4-pyridinol or an alkanoic ester thereof wherein the naphthoquinone and 4-pyridinol or alkanoic ester thereof are present in a potentiating ratio.
Claim 2
Dependent Claim
30 words
1) A combination of an antiprotozoal naphthoquinone and a 4-pyridinol or an alkanoic ester thereof wherein the naphthoquinone and 4-pyridinol or alkanoic ester thereof are present in a potentiating ratio.
Claim 3
Dependent Claim
81 words
2) A combination as claimed in claim 1 in which the naphthoquinone is a compound of the formula (I) wherein R 1 , is a straight or branched chain C 1-14 alkyl group, a C 3-8 cycloalkyl or a C 3-8 cycloalkyl-C 1-8 alkyl group, such groups being optionally substituted by one or more substituents selected from C 1-6 alkyl or cycloalkyl, C l-6 alkoxy, phenyl and hydroxy groups; and R is hydroxy, Cl-4 acyl, C l-6 alkoxy, hydrogen or halogen.
Claim 4
Dependent Claim
18 words
3) A combination as claimed in claim 2 in which R 1 comprises or contains a cyclohexyl moiety.
Claim 5
Dependent Claim
16 words
4) A combination as claimed in claim 3 in which R is a 4-substituted cyclohexyl group.
Claim 6
Dependent Claim
15 words
5) A combination as claimed in claim 4 in which R is a 4-t-butylcyclohexyl group.
Claim 7
Dependent Claim
53 words
6) A combination as claimed in any of the preceding claims in which the 4-pyridinol is a compound of formula (II): wherein each R3 is the same or different and is a C 1-4 alkyl group, each X is the same or different, and is halogen, or a C 1-6 alkanoic ester thereof.
Claim 8
Dependent Claim
31 words
A combination as claimed in any of the preceding claims in which the weight ratio of naphthoquinone to 4-pyridinol or alkanoic ester thereof is in the range of 1:500 to 1:1.
Claim 9
Dependent Claim
16 words
A combination as claimed in any of the preceding claims for use as a therapeutic agent.
Claim 10
Dependent Claim
18 words
A combination as claimed in claim 8 for use in the treatment or prophylaxis of a protozoal disease.
Claim 11
Dependent Claim
18 words
A combination as claimed in claim 9 for use in the treatment or prophylaxis of malaria in man.
Claim 12
Dependent Claim
22 words
Therapeutic formulations comprising a combination as claimed in any of the preceding claims together with one or more pharmaceutically acceptable carriers therefor.
References Cited (Backward Citations)
US2553648A
Cited
US3206358A
Cited
US3347742A
Cited
US3367830A
Cited
DE2641343A1
Cited
GB1553424A
Cited
EP0002228A2
Cited
EP0077550A2
Cited
EP0077551A2
Cited
USPTO Annuity & Maintenance Windows
Maintenance schedule is calculated for granted US utility patents.