US4981841A
Expired / Lapsed
US
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Methods and materials for use in corneal wound healing
Assignee: Allergan Inc
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Filing: 1990-03-07
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Granted: 1991-01-01
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Expires: 2010-03-07
Abstract
Abstract Improvement in healing of wounds of the corneal stroma is obtained by placing into the wounds a corneal mortar composition comprising an extracellular matrix material and an ophthalmologically compatible carrier material, the composition having a sufficiently high viscosity to retain it within the wound under wound-healing conditions.
Inventors
- 👤 David R. Gibson
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 22:35
CPC Classifications
A; A61; A61F; A61F2/00; A61F2/02; A61F2/14; A61F2/142; A61F2/147; A61F9/00; A61F9/007; A61K; A61K9/00; A61K9/0012; A61K9/0048; A61K9/0051; A61L; A61L26/00; A61L26/0009; A61L26/0023; A61L26/0061; A61L26/0066; A61F13/00; A61F13/15; A61F13/84; A61F13/8405; A61F2013/00089; A61F2013/00217; A61F2013/00221; A61L2300/00; A61L2300/40; A61L2300/412; A61L2300/414
Claims Analysis
Total Claims: 14
Claim 1
Independent Claim
62 words
A corneal mortar composition comprising (a) an extracellular matrix material comprising fibronectin and at least one material selected from the group consisting of chondroitin sulfate, hyaluronic acid, keratin sulfate and heparin and (b) an ophthalmologically compatible carrier material, said composition having a viscosity sufficiently high to retain the extracellular matrix material within a stromal wound or incision under wound-healing or incision-healing conditions.
Claim 2
Dependent Claim
62 words
A corneal mortar composition comprising (a) an extracellular matrix material comprising fibronectin and at least one material selected from the group consisting of chondroitin sulfate, hyaluronic acid, keratin sulfate and heparin and (b) an ophthalmologically compatible carrier material, said composition having a viscosity sufficiently high to retain the extracellular matrix material within a stromal wound or incision under wound-healing or incision-healing conditions.
Claim 3
Dependent Claim
19 words
A corneal mortar composition as claimed in claim 1, wherein the corneal mortar composition further comprises a growth factor.
Claim 4
Dependent Claim
17 words
A corneal mortar composition as claimed in claim 2, wherein the growth factor is epidermal growth factor.
Claim 5
Dependent Claim
20 words
A corneal mortar composition as claimed in claim 1, which contains from about 2% to about 90% by weight fibronectin.
Claim 6
Dependent Claim
24 words
A corneal mortar composition as claimed in claim 1, wherein the corneal mortar composition comprises fibronectin, chondroitin sulfate and an ophthalmologically compatible carrier material.
Claim 7
Dependent Claim
25 words
A corneal mortar composition as claimed in claim 1, wherein the corneal mortar composition comprises fibronectin, chondroitin sulfate, collagen and an ophthalmologically compatible carrier material.
Claim 8
Dependent Claim
27 words
A corneal mortar composition as claimed in claim 2, wherein the corneal mortar composition comprises fibronectin, chondroitin sulfate, a growth factor and an ophthalmologically compatible carrier material.
Claim 9
Dependent Claim
50 words
A corneal mortar composition as claimed in claim 1, wherein the corneal mortar composition comprises from about 0.5% to about 40% fibronectin, from about 0.5% to about 75% chondroitin sulfate and from about 25% to about 99% of an ophthalmologically compatible carrier material, based on total weight of the composition.
Claim 10
Dependent Claim
50 words
A corneal mortar composition as claimed in claim 1, wherein the corneal mortar composition comprises from about 0.5% to about 40% fibronectin, from about 0.5% to about 75% chondroitin sulfate, from about 0.5% to about 50% collagen and from about 25% to about 98.5% of an ophthalmologically compatible carrier material.
Claim 11
Dependent Claim
60 words
A corneal mortar composition as claimed in claim 1, wherein the corneal mortar composition comprises from about 0.5% to about 40% fibronectin, from about 0.5% to about 75% chondroitin sulfate, from about 25% to about 99% phosphate buffered saline solution, based on total weight of the composition, and from about 0.01 μg/ml to about 100 μg/ml of a growth factor.
Claim 12
Dependent Claim
17 words
A corneal mortar composition as claimed in claim 10, wherein the growth factor is epidermal growth factor.
Claim 13
Dependent Claim
63 words
A corneal mortar composition comprising (a) an extracellular matrix material comprising vitronectin and at least one material selected for the group consisting of chondroitin sulfate, hyaluronic acid, keratin sulfate and heparin and (b) an ophthalmologically compatible carrier material, said composition having a viscosity sufficiently high to retain the extracellular matrix material with a stromal wound or incision under wound healing or incision-healing conditions.
Claim 14
Dependent Claim
63 words
A corneal mortar composition comprising (a) an extracellular matrix material comprising vitronectin and at least one material selected for the group consisting of chondroitin sulfate, hyaluronic acid, keratin sulfate and heparin and (b) an ophthalmologically compatible carrier material, said composition having a viscosity sufficiently high to retain the extracellular matrix material with a stromal wound or incision under wound healing or incision-healing conditions.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1993-12-31 | 1994-07-02 | 1995-01-01 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1997-12-31 | 1998-07-02 | 1999-01-01 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2001-12-31 | 2002-07-02 | 2003-01-01 | $7700.00 | Window Closed / Lapsed |