US4977165A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Piperidine derivative and therapeutic and preventive agents for arrhythmia containing same
Assignee: Eisai Co Ltd
•
Filing: 1988-08-19
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Granted: 1990-12-11
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Expires: 2008-08-19
Abstract
Abstract A piperidine compound has the generic formula and is useful to treat arrhythmia. ##STR1## in which R 1 is a lower alkyl and W is: ##STR2## X is --S--, --SO-- or --SO 2 --, R 2 is hydrogen or --(CH 2 ) n --Y, n is an integer of 1 to 5, Y is an aryl, pyridyl or a substituted pyridyl, X' is --CO-- or --CH(OH)--, p is an integer of 1 to 4, R 12 is hydrogen or a lower alkyl, Y' is --(CH 2 ) m --A, m is 1 or 2, A is an aryl, a substituted aryl, pyridyl or a substituted pyridyl, R 12 and Y may form a 5- or 6-membered ring or a 5- or 6-membered ring having one or more substituents and R 22 is hydrogen, a halogen, a lower alkyl, a lower alkoxy or hydroxy.
Inventors
- 👤 Hitoshi Oinuma
- 👤 Motosuke Yamanaka
- 👤 Kazutoshi Miyake
- 👤 Tomonori Hoshiko
- 👤 Norio Minami
- 👤 Tadao Shoji
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 08:29
CPC Classifications
C; C07; C07D; C07D401/00; C07D401/02; C07D401/06; A; A61; A61P; A61P9/00; A61P9/06; C07D211/00; C07D211/04; C07D211/06; C07D211/08; C07D211/10; C07D211/14; C07D211/18; C07D211/30; C07D211/32; C07D211/36; C07D211/54; C07D213/00; C07D213/02; C07D213/04; C07D213/24; C07D213/36; C07D213/38
Claims Analysis
Total Claims: 21
Claim 1
Independent Claim
101 words
A compound having the formula ##STR78## in which R 1 is lower alkyl; X is --S--, -- SO--or --SO 2 --; and R 2 is hydrogen or --(CH 2 ) n --Y, wherein n is an integer of 1 to 5, and Y is (1) phenyl, (2) phenyl substituted with from 1 to 3 substituents selected from the group consisting of alkyl having 1 to 6 carbon atoms, alkoxy having from 1 to 6 carbon atoms and halogen or (3) ##STR79## in which R 3 is hydrogen, lower alkyl, lower alkoxy, cyano, hydroxyl or halogen or a pharmacologically acceptable salt thereof.
Claim 2
Dependent Claim
101 words
A compound having the formula ##STR78## in which R 1 is lower alkyl; X is --S--, -- SO--or --SO 2 --; and R 2 is hydrogen or --(CH 2 ) n --Y, wherein n is an integer of 1 to 5, and Y is (1) phenyl, (2) phenyl substituted with from 1 to 3 substituents selected from the group consisting of alkyl having 1 to 6 carbon atoms, alkoxy having from 1 to 6 carbon atoms and halogen or (3) ##STR79## in which R 3 is hydrogen, lower alkyl, lower alkoxy, cyano, hydroxyl or halogen or a pharmacologically acceptable salt thereof.
Claim 3
Dependent Claim
14 words
A compound as claimed in claim 1 and a in which X is --SO--.
Claim 4
Dependent Claim
22 words
A pharmaceutical composition which comprises a pharmacologically effective amount of a compound as defined in claim 1 and a pharmacologically acceptable carrier.
Claim 5
Dependent Claim
27 words
A method of treating a patient afflicted with arrhythmia which comprises administering to the patient a therapeutically effective amount of a compound as defined in claim 1
Claim 6
Dependent Claim
14 words
A compound as claimed in claim 1 in which X is --SO 2 --.
Claim 7
Dependent Claim
12 words
A compound as claimed in claim 1 in which X is --S--.
Claim 8
Dependent Claim
13 words
A compound as claimed in claim 1 in which R 2 is hydrogen.
Claim 9
Dependent Claim
17 words
A compound as claimed in claim 1 in which R 2 is --(CH 2 ) n --Y.
Claim 10
Dependent Claim
44 words
A compound as claimed in claim 8 in which Y is phenyl or phenyl substituted with from 1 to 3 substituents selected from the group consisting of alkyl having 1 to 6 carbon atoms, alkoxy having from 1 to 6 carbon atoms and halogen.
Claim 11
Dependent Claim
17 words
A compound as claimed in claim 9 in which n is an integer of 1 or 2.
Claim 12
Dependent Claim
25 words
A compound as claimed in claim 8 in which Y is ##STR80## wherein R 3 is hydrogen, lower alkyl, lower alkoxy, cyano, hydroxyl or halogen.
Claim 13
Dependent Claim
17 words
A compound as claimed in claim 1 in which R 2 is pyridylmethyl, pyridylethyl, methylpyridylmethyl or methylpyridylethyl.
Claim 14
Dependent Claim
11 words
A compound as claimed in claim 1 having the formula ##STR81##
Claim 15
Dependent Claim
11 words
A compound as claimed in claim 1 having the formula ##STR82##
Claim 16
Dependent Claim
11 words
A compound as claimed in claim 1 having the formula ##STR83##
Claim 17
Dependent Claim
11 words
A compound as claimed in claim 1 having the formula ##STR84##
Claim 18
Dependent Claim
11 words
A compound as claimed in claim 1 having the formula ##STR85##
Claim 19
Dependent Claim
11 words
A compound as claimed in claim 1 having the formula ##STR86##
Claim 20
Dependent Claim
11 words
A compound as claimed in claim 1 having the formula ##STR87##
Claim 21
Dependent Claim
11 words
A compound as claimed in claim 1 having the formula ##STR88##
References Cited (Backward Citations)
US3341584A
Cited
US3968242A
Cited
US4044150A
Cited
US4666935A
Cited
US4544654A
Cited
EP0158775A1
Cited
US4876262A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1993-12-10 | 1994-06-11 | 1994-12-11 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1997-12-10 | 1998-06-11 | 1998-12-11 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2001-12-10 | 2002-06-11 | 2002-12-11 | $7700.00 | Window Closed / Lapsed |