US4044150A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Antihypertensive 4'-[1-hydroxy-2-[(1-phenoxy ethyl)-amino]ethyl]methanesulfonanilide and salts thereof and therapeutic use
Assignee: Mead Johnson and Co LLC
•
Filing: 1976-06-18
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Granted: 1977-08-23
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Expires: 1996-06-18
Abstract
Abstract The sulfonamidophenethanolamine 4'-[1-hydroxy-2-[(2-phenoxyethyl)amino]ethyl]methanesulfonanilide is an antihypertensive beta-adrenergic blocking agent selectively lowering blood pressure with minimal reduction of heart rate.
Inventors
- 👤 William E. Kreighbaum
- 👤 Herbert R. Roth
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 08:42
CPC Classifications
C; C07; C07C; C07C311/00; C07C311/01; C07C311/02
Claims Analysis
Total Claims: 14
Claim 1
Independent Claim
19 words
A compound selected from the group consisting of 4'-[1-hydroxy-2-[(2-phenoxyethyl)amino]ethyl]methanesulfonanilide and the pharmaceutically acceptable acid addition and metal salts thereof.
Claim 2
Dependent Claim
19 words
A compound selected from the group consisting of 4'-[1-hydroxy-2-[(2-phenoxyethyl)amino]ethyl]methanesulfonanilide and the pharmaceutically acceptable acid addition and metal salts thereof.
Claim 3
Dependent Claim
9 words
The compound defined in claim 1 which is 4'-[1-hydroxy-2-[(2-phenoxyethyl)amino]ethyl]methanesulfonanilide.
Claim 4
Dependent Claim
10 words
The compound defined in claim 1 which is 4'-[1-hydroxy-2-[(2-phenoxyethyl)amino]ethyl]methanesulfonanilide hydrochloride.
Claim 5
Dependent Claim
11 words
The compound defined in claim 1 which is 4'-[1-hydroxy-2-[(2-phenoxyethyl)amino]ethyl]methanesulfonanilide sodium salt.
Claim 6
Dependent Claim
34 words
An antihypertensive process which comprises systemically administering to a hypertensive mammal an effective antihypertensive amount of a compound selected from the group consisting of 4'-[1-hydroxy-2-[(2-phenoxyethyl)amino]ethyl]methanesulfonanilide and pharmaceutically acceptable acid addition and metal salts thereof.
Claim 7
Dependent Claim
34 words
An antihypertensive process which comprises systemically administering to a hypertensive mammal an effective antihypertensive amount of a compound selected from the group consisting of 4'-[1-hydroxy-2-[(2-phenoxyethyl)amino]ethyl]methanesulfonanilide and pharmaceutically acceptable acid addition and metal salts thereof.
Claim 8
Dependent Claim
10 words
The process of claim 5 wherein said compound is 4'-[1-hydroxy-2-[(2-phenoxyethyl)amino]ethyl]methanesulfonanilide.
Claim 9
Dependent Claim
11 words
The process of claim 5 wherein said compound is 4'-[1-hydroxy-2-[(2-phenoxyethyl)amino]ethyl]methanesulfonanilide hydrochloride.
Claim 10
Dependent Claim
20 words
The process of claim 5 wherein said effective dose is from 0.05 to 15 mg./kg. body weight of said mammal.
Claim 11
Dependent Claim
40 words
A pharmaceutical dosage unit adapted for systemic administration to a hypertensive mammal comprising a pharmaceutical carrier and an effective antihypertensive amount of a compound selected from the group consisting of 4'-[1-hydroxy-2-[(2-phenoxyethyl)amino]ethyl]methanesulfonanilide and pharmaceutically acceptable acid addition and metal salts thereof.
Claim 12
Dependent Claim
40 words
A pharmaceutical dosage unit adapted for systemic administration to a hypertensive mammal comprising a pharmaceutical carrier and an effective antihypertensive amount of a compound selected from the group consisting of 4'-[1-hydroxy-2-[(2-phenoxyethyl)amino]ethyl]methanesulfonanilide and pharmaceutically acceptable acid addition and metal salts thereof.
Claim 13
Dependent Claim
10 words
The composition of claim 9 wherein said compound is 4'-[1-hydroxy-2-[(2-phenoxyethyl)amino]ethyl]methanesulfonanilide.
Claim 14
Dependent Claim
11 words
The composition of claim 9 wherein said compound is 4'-[1-hydroxy-2-[(2-phenoxyethyl)amino]ethyl]methanesulfonanilide hydrochloride.
References Cited (Backward Citations)
US3341584A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-08-22 | 1981-02-21 | 1981-08-23 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-08-22 | 1985-02-21 | 1985-08-23 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-08-22 | 1989-02-21 | 1989-08-23 | $7700.00 | Window Closed / Lapsed |