US4975430A
Expired / Lapsed
US
⏱️ 0.0 years remaining
CNQX and its analogs as therapeutics for degenerative neural diseases
Assignee: Oregon Health & Science University
•
Filing: 1989-06-16
•
Granted: 1990-12-04
•
Expires: 2009-06-16
Abstract
Abstract Compounds of the formula <IMAGE> (1) wherein each X is independently nitro or cyano and wherein each Y is independently H, lower alkyl (1-4C), lower alkoxy (-4C), or CF3 have been shown to be successful antagonists of NMDA receptors. Accordingly, these compounds are useful in the treatment of neuronal conditions associated with stimulation of the NMDA receptor.
Inventors
- 👤 Craig E. Jahr
- 👤 Robin Lester
- 👤 Eckard Weber
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-05 20:25
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/33; A61K31/395; A61K31/495
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
73 words
A method to treat neuronal diseases mediated by stimulation of the NMOA receptor which method comprises administering to a subject in need of such treatment an effective amount of a compound of the formula ##STR3## wherein each X is independently nitro or cyano and wherein each Y is independently H, lower alkyl (1-4C), lower alkoxy (1-4C), or CF 3 , or a pharmaceutical composition thereof in an amount effective to ameliorate said condition.
Claim 2
Independent Claim
73 words
A method to treat neuronal diseases mediated by stimulation of the NMOA receptor which method comprises administering to a subject in need of such treatment an effective amount of a compound of the formula ##STR3## wherein each X is independently nitro or cyano and wherein each Y is independently H, lower alkyl (1-4C), lower alkoxy (1-4C), or CF 3 , or a pharmaceutical composition thereof in an amount effective to ameliorate said condition.
Claim 3
Dependent Claim
25 words
The method of claim 1 wherein both Y are H, and both X are nitro or one X is nitro and the other is cyano.
Claim 4
Dependent Claim
10 words
The method of claim 2 wherein both X are nitro.
Claim 5
Dependent Claim
15 words
The method of claim 2 wherein one X is nitro and the other is cyano.
Claim 6
Dependent Claim
37 words
The method of claim 1 wherein both Y are methyl or wherein 1 Y is methyl and the other is H, and wherein both X are nitro or one X is nitro and the other is cyano.
References Cited (Backward Citations)
US4812458A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1993-12-03 | 1994-06-04 | 1994-12-04 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1997-12-03 | 1998-06-04 | 1998-12-04 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2001-12-03 | 2002-06-04 | 2002-12-04 | $7700.00 | Window Closed / Lapsed |