US4812458A
Expired / Lapsed
US
⏱️ 0.0 years remaining
6,7-disubstituted-2,3-dihydroxyquinoxaline compounds, pharmaceutical compositions thereof, and their use as neuroleptics
Assignee: Novo Nordisk AS
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Filing: 1987-09-02
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Granted: 1989-03-14
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Expires: 2007-09-02
Abstract
Abstract Heterocyclic dihydroxyquinoxaline compounds having the formula ##STR1## wherein R 1 is halogen, CN, CF 3 , ethynyl, or N 3 and R 2 is SO 2 C 1-3 -alkyl, CF 3 , NO 2 , ethynyl, or CN. The invention also relates to a method of preparing the compounds, pharmaceutical compositions thereof, and their use. The compounds are useful in the treatment of indications caused by hyperactivity of the excitatory neurotransmitters, particularly the quisqualate receptors, and especially as neuroleptics.
Inventors
- 👤 Tage Honore
- 👤 Jorgen Drejer
- 👤 Poul Jacobsen
- 👤 Flemming E. Nielsen
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-02 16:23
CPC Classifications
C; C07; C07D; C07D241/00; C07D241/36; C07D241/38; C07D241/40; C07D241/44
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
40 words
A heterocyclic dihydroxyquinoxaline compound having the formula I ##STR9## wherein R 1 is halogen, CN, CF 3 , ethynyl, or N 3 and R 2 is SO 2 C 1-3 -alkyl, CF 3 , NO 2 , ethynyl, or CN.
Claim 2
Dependent Claim
40 words
A heterocyclic dihydroxyquinoxaline compound having the formula I ##STR9## wherein R 1 is halogen, CN, CF 3 , ethynyl, or N 3 and R 2 is SO 2 C 1-3 -alkyl, CF 3 , NO 2 , ethynyl, or CN.
Claim 3
Dependent Claim
23 words
A compound of claim 1, wherein R 1 is Cl, CN or CF 3 and R 2 is CN, or NO 2 .
Claim 4
Dependent Claim
8 words
A compound of claim 1, which is 6-cyano-7-nitro-2,3-dihydroxyquinoxaline.
Claim 5
Dependent Claim
8 words
A compound of claim 1, which is 6-chloro-7-cyano-2,3-dihydroxyquinoxaline.
Claim 6
Dependent Claim
8 words
A compound of claim 1, which is 6-trifluoromethyl-7-cyano-2,3-dihydroxyquinoxaline.
Claim 7
Dependent Claim
32 words
A pharmaceutical composition useful as a neuroleptic comprising as active component a neuroleptically-effective amount of a heterocyclic dihydroxyquinoxaline compound according to claim 1 or a pharmaceutically-acceptable salt thereof and a pharmaceutically-acceptable carrier.
Claim 8
Dependent Claim
23 words
A pharmaceutical composition according to claim 6 in the form of an oral dosage unit containing about 50-200 mg of the active compound.
Claim 9
Dependent Claim
35 words
A method of treating hyperactivity of the excitatory neurotransmitters in a subject in need thereof, which comprises the step of administering to the said subject a neuroleptically-effective amount of a dihydroxyquinoxaline compound of claim 1.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1992-03-13 | 1992-09-12 | 1993-03-14 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-03-13 | 1996-09-12 | 1997-03-14 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-03-13 | 2000-09-12 | 2001-03-14 | $7700.00 | Window Closed / Lapsed |