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US4968692A
Expired / Lapsed
US
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Attenuation of ethyl alcohol intoxication with alpha-2 adrenoceptor antagonists
Assignee: United States Department of Health and Human Services
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Filing: 1989-01-06
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Granted: 1990-11-06
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Expires: 2009-01-06
Abstract
Abstract A method is provided for attenuating the intoxicating effects of ethyl alcohol in a patient, by administering to a patient in need thereof, an alpha-2 adrenoceptor antagonist compound. Two preferred compounds useful in the present invention, each being a highly potent and selective alpha-2 adrenoceptor antagonist, are atipamezole and idazoxan.
Inventors
- 👤 Markku Linnoila
- 👤 Richard G. Lister
- 👤 Michael J. Durcan
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 16:29
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/33; A61K31/395; A61K31/41; A61K31/415; A61K31/435; A61K31/47; A61K31/475
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
37 words
A method of attenuating ethyl alcohol intoxication, in a patient in need thereof, which method comprises administering to said patient by injection an effective ethyl alcohol intoxication inhibiting amount of 4(5)-(2,3-dihydro-2-ethyl-1H-inden-2-yl)imidazole or a pharmaceutically acceptable salt thereof.
Claim 2
Independent Claim
37 words
A method of attenuating ethyl alcohol intoxication, in a patient in need thereof, which method comprises administering to said patient by injection an effective ethyl alcohol intoxication inhibiting amount of 4(5)-(2,3-dihydro-2-ethyl-1H-inden-2-yl)imidazole or a pharmaceutically acceptable salt thereof.
Claim 3
Independent Claim
37 words
A method of attenuating ethyl alcohol intoxication, in a patient in need thereof, which method comprises administering to said patient by injection an effective ethyl alcohol intoxication inhibiting amount of 2-(2-(1,4-benzodioxanyl))-2-imidazoline or a pharmaceutically acceptable salt thereof.
Claim 4
Independent Claim
37 words
A method of attenuating ethyl alcohol intoxication, in a patient in need thereof, which method comprises administering to said patient by injection an effective ethyl alcohol intoxication inhibiting amount of 2-(2-(1,4-benzodioxanyl))-2-imidazoline or a pharmaceutically acceptable salt thereof.
Claim 5
Dependent Claim
27 words
The method of claim 1, wherein said 4(5)-(2,3-dihydro-2-ethyl-1H-inden-2-yl)imidazole or a pharmaceutically acceptable salt thereof is administered in an amount of 0.01 to 10.0 mg/kg of body weight.
Claim 6
Dependent Claim
27 words
The method of claim 2, wherein said 2-(2-(1,4-benzodioxanyl))-2-imidazoline or a pharmaceutically acceptable salt thereof is administered in an amount of 0.01 to 10.0 mg/kg of body weight.
Claim 7
Independent Claim
65 words
A method of attenuating ethyl alcohol intoxication, which method comprises administering to an intoxicated patient in need thereof, an effective intoxication attenuating amount of a compound having alpha-2 adrenoceptor antagonist properties, selected from the group consisting of: atipamezole, idazoxan, imiloxan, Yohimbine, Wyeth Compound WY 26703, Chinoin Compound CH 38083, Glaxo Compound GR 50360A, and Daiichi Seiyaku Compound DG 5128, or a pharmaceutically acceptable salt thereof.
Claim 8
Independent Claim
65 words
A method of attenuating ethyl alcohol intoxication, which method comprises administering to an intoxicated patient in need thereof, an effective intoxication attenuating amount of a compound having alpha-2 adrenoceptor antagonist properties, selected from the group consisting of: atipamezole, idazoxan, imiloxan, Yohimbine, Wyeth Compound WY 26703, Chinoin Compound CH 38083, Glaxo Compound GR 50360A, and Daiichi Seiyaku Compound DG 5128, or a pharmaceutically acceptable salt thereof.
Claim 9
Dependent Claim
16 words
The method of claim 5, wherein said compound is atipamezole, or a pharmaceutically acceptable salt thereof.
Claim 10
Dependent Claim
11 words
The method of claim 5, wherein said compound is atipamezole hydrochloride.
Claim 11
Dependent Claim
16 words
The method of claim 5, wherein said compound is idazoxan, or a pharmaceutically acceptable salt thereof.
Claim 12
Dependent Claim
11 words
The method of claim 5, wherein said compound is idazoxan hydrochloride.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 1993-11-05 | 1994-05-07 | 1994-11-06 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1997-11-05 | 1998-05-07 | 1998-11-06 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2001-11-05 | 2002-05-07 | 2002-11-06 | $7700.00 | Window Closed / Lapsed |