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US4965350A
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Pyridopyrimidine nucleotide compounds
Assignee: Teijin Ltd
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Filing: 1989-05-11
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Granted: 1990-10-23
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Expires: 2009-05-11
Abstract
Abstract Pyridopyrimidine nucleotide derivatives expressed by formula (I), which are fluorescent and capable of forming base pairing with guanine or adenine, and oligo- or polynucleotide which have at least one of these derivatives in their molecules or at their molecular terminals: ##STR1## wherein X 1 and X 1 respectively represent ##STR2## (in which n indicates an integer of 0, 1, 2, or 3; however, in no case X 1 and Y 1 both indicate n=O); Z 1 indicates a hydrogen atom or ##STR3## (in which n indicates an integer of 1, 2, or 3); W 1 indicates a hydrogen atom or a hydroxyl group. As for R 1 and R 2 , in case where R 1 is an amino group or halogen, R 2 indicates a single bond between the carbon atom at the 7-position and the nitrogen atom at the 8-position, and in case where R 2 is a hydrogen atom or an lower alkyl group, R 1 indicates a carbonyl bond ##STR4## formed with the carbon atom at the 7-position.
Inventors
- 👤 Hideo Inoue
- 👤 Eiko Ohtsuka
- 👤 Akihiro Imura
- 👤 Kenichi Masuda
- 👤 Takashi Kamimura
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-05 15:14
CPC Classifications
C; C07; C07H; C07H19/00; C07H19/02; C07H19/04; C07H19/06; C07H19/10; C07H21/00
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
144 words
A pyridopyrimidine nucleotide derivative expressed by formula (I): ##STR23## wherein X 1 and Y 1 each represent ##STR24## (wherein n is an integer of 0, 1, 2, or 3, provided that n is not 0 for both X 1 and Y 1 ); wherein Z 1 represents a hydrogen atom or ##STR25## (wherein m is an integer of 0, 1, 2, or 3); wherein W 1 represents a hydrogen atom or a hydroxyl group, provided that Z 1 is not ##STR26## when W 1 represents a hydroxyl group; and wherein R 1 represents an amino group or halogen atom and R 2 represents a single bond between the carbon atom at the 7-position and the nitrogen atom at the 8-position or R 1 represents a carbonyl bond ##STR27## formed with the carbon atom at the 7-position and R 2 represents a lower alkyl group.
Claim 2
Dependent Claim
144 words
A pyridopyrimidine nucleotide derivative expressed by formula (I): ##STR23## wherein X 1 and Y 1 each represent ##STR24## (wherein n is an integer of 0, 1, 2, or 3, provided that n is not 0 for both X 1 and Y 1 ); wherein Z 1 represents a hydrogen atom or ##STR25## (wherein m is an integer of 0, 1, 2, or 3); wherein W 1 represents a hydrogen atom or a hydroxyl group, provided that Z 1 is not ##STR26## when W 1 represents a hydroxyl group; and wherein R 1 represents an amino group or halogen atom and R 2 represents a single bond between the carbon atom at the 7-position and the nitrogen atom at the 8-position or R 1 represents a carbonyl bond ##STR27## formed with the carbon atom at the 7-position and R 2 represents a lower alkyl group.
Claim 3
Dependent Claim
45 words
The pyridopyrimidine nucleotide according to claim 1, wherein X 1 and Y 1 each represent ##STR28## (wherein n is an integer of 1, 2, or 3); wherein Z 1 represents a hydrogen atom or a hydroxyl group; and wherein W 1 represents a hydrogen atom.
Claim 4
Dependent Claim
121 words
An oligo- or polynucleotide which comprises at least one of a moiety having the structure: ##STR29## wherein X is hydrogen, a nucleotide or --PO 3 H; wherein W 1 represents a hydrogen atom or a hydroxyl group; wherein Z 1 represents a hydrogen atom or a hydroxyl group; however in no case do both W 1 and Z 1 represent a hydroxyl group; wherein R 1 represents an amino group or halogen and R 2 represents a single bond between the carbon atom at the 7-position and the nitrogen atom at the 8-position or R 1 represents a carbonyl bond ##STR30## formed with the carbon atom at the 7-position and R 2 represents a hydrogen atom or a lower alkyl group.
Claim 5
Dependent Claim
121 words
An oligo- or polynucleotide which comprises at least one of a moiety having the structure: ##STR29## wherein X is hydrogen, a nucleotide or --PO 3 H; wherein W 1 represents a hydrogen atom or a hydroxyl group; wherein Z 1 represents a hydrogen atom or a hydroxyl group; however in no case do both W 1 and Z 1 represent a hydroxyl group; wherein R 1 represents an amino group or halogen and R 2 represents a single bond between the carbon atom at the 7-position and the nitrogen atom at the 8-position or R 1 represents a carbonyl bond ##STR30## formed with the carbon atom at the 7-position and R 2 represents a hydrogen atom or a lower alkyl group.
Claim 6
Dependent Claim
22 words
The oligo- or polynucleotide according to claim 3, wherein Z 1 represents a hydrogen atom and W 1 represents a hydrogen atom.
References Cited (Backward Citations)
EP0063879A2
Cited
US4711955A
Cited
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