US4965074A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Method of treating memory impairment
Assignee: Novartis Corp
•
Filing: 1988-08-15
•
Granted: 1990-10-23
•
Expires: 2008-08-15
Abstract
Abstract A method for the treatment of memory impairment, especially Senile Dementia of the Alzheimer's Type, by administering to a patient in need thereof an effective amount of nicotine or an N-lower alkyl analog thereof by the transdermal route.
Inventors
- 👤 Lewis J. Leeson
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 11:33
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/33; A61K31/395; A61K31/435; A61K31/44; A61K31/455; A61K31/40; A61K31/445; A61K31/47; A61K31/485; A61K9/00; A61K9/0002; A61K9/0004; A61K9/70; A61K9/7023
Claims Analysis
Total Claims: 14
Claim 1
Independent Claim
32 words
A method of treating memory impairment comprising administering to a patient in need thereof an effective amount of a compound of the formula ##STR10## wherein Z represents H or lower alkyl transdermally.
Claim 2
Independent Claim
32 words
A method of treating memory impairment comprising administering to a patient in need thereof an effective amount of a compound of the formula ##STR10## wherein Z represents H or lower alkyl transdermally.
Claim 3
Dependent Claim
9 words
The method of claim 1 wherein Z is methyl.
Claim 4
Dependent Claim
16 words
The method of claim 1 wherein said memory impairment is senile dementia of the Alzheimer's type.
Claim 5
Dependent Claim
37 words
The method of claim 1 wherein said transdermal administration is from a device comprising an impermeable backing member, an active agent reservoir thereon, and an adhesive portion, said active agent reservoir containing said compound of formula A.
Claim 6
Dependent Claim
44 words
The method of claim 4 wherein said device further comprises a membrane through which said active agent is permeable and through which said active agent must pass before it can reach the skin surface of said patient to which said device has been applied.
Claim 7
Dependent Claim
20 words
The method of claim 5 wherein said membrane is a rate controlling membrane for said active agent in said device.
Claim 8
Dependent Claim
27 words
The method of claim 4 wherein said active agent reservoir is a matrix which is a release rate controlling matrix for said active agent in said device.
Claim 9
Dependent Claim
17 words
The method of claim 7 wherein said release of active agent from said matrix is by diffusion.
Claim 10
Dependent Claim
18 words
The method of claim 7 wherein said release of active agent from said matric is by microporous flow.
Claim 11
Dependent Claim
13 words
The method of claim 4 wherein said device further comprises a flux enhancer.
Claim 12
Dependent Claim
12 words
The method of claim 4 wherein said device further comprises a buffer.
Claim 13
Dependent Claim
24 words
The method of claim 1 wherein said compound of formula A is administered to said patient at a rate of 0.02 to 2.5 mg/hr.
Claim 14
Dependent Claim
24 words
The method of claim 12 wherein said compound of formula A is administered to said patient at a rate of 0.05 to 2 mg/hr.
References Cited (Backward Citations)
US3916899A
Cited
EP0040861A1
Cited
US4573996A
Cited
US4573995A
Cited
US4647591A
Cited
US4839174A
Cited
US4781924A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1993-10-22 | 1994-04-23 | 1994-10-23 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1997-10-22 | 1998-04-23 | 1998-10-23 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2001-10-22 | 2002-04-23 | 2002-10-23 | $7700.00 | Window Closed / Lapsed |