Patent US4959612A successfully refreshed from Google Patents.
US4959612A
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Method of heteronuclear decoupling in magnetic resonance spectroscopy, and device for determining a spectrum
Assignee: US Philips Corp
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Filing: 1989-05-26
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Granted: 1990-09-25
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Expires: 2009-05-26
Abstract
Abstract A method of heteronuclear decoupling in magnetic resonance spectroscopy and a device for determining a spectrum where spectra of a first type of nucleus which is spin-coupled to a second type of nucleus are decoupled inter alia in order to obtain a higher resolution. In inter alia phosphorous spectroscopy, during signal acquisition of resonance signals of the first type of nucleus, decoupling pulses are applied to the second type of nucleus, which decoupling pulses have been modulated in amplitude as well as in frequency or phase. The decoupling pulses need hardly be optimized. Very good decoupling is achieved, notably when use is made of surface coils for the transmitter and receiver coils exhibiting a substantial field inhomogeneity. When surface coils are used, suitable decoupling is achieved across a comparatively large volume.
Inventors
- 👤 Peter R. Luyten
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 16:46
CPC Classifications
G; G01; G01R; G01R33/00; G01R33/20; G01R33/44; G01R33/46; G01R33/48; G01R33/483; G01R33/4833
Claims Analysis
Total Claims: 22
Claim 1
Independent Claim
113 words
A method of heteronuclear decoupling in magnetic resonance spectroscopy, where magnetic resonance signals originating from a first type of nucleus in an object are generated at least by irradiating the first type of nucleus with an RF electromagnetic excitation pulse, the first type of nucleus being spin-coupled to a second type of nucleus in the object, a pulse train of inversion pulses being applied to the second type of nucleus, at least during signal acquisition of the magnetic resonance signals, in order to decouple the first type of nucleus from the second type of nucleus, characterized in that the inversion pulses are pulses modulated in amplitude as well as in frequency or phase.
Claim 2
Independent Claim
113 words
A method of heteronuclear decoupling in magnetic resonance spectroscopy, where magnetic resonance signals originating from a first type of nucleus in an object are generated at least by irradiating the first type of nucleus with an RF electromagnetic excitation pulse, the first type of nucleus being spin-coupled to a second type of nucleus in the object, a pulse train of inversion pulses being applied to the second type of nucleus, at least during signal acquisition of the magnetic resonance signals, in order to decouple the first type of nucleus from the second type of nucleus, characterized in that the inversion pulses are pulses modulated in amplitude as well as in frequency or phase.
Claim 3
Dependent Claim
24 words
A method as claimed in claim 1, characterized in that the amplitude modulation follows a sech function, the frequency modulation following a tanh function.
Claim 4
Dependent Claim
27 words
A method as claimed in claim 1, characterized in that the amplitude modulation follows a sech function, the phase modulation following the integral of a tanh function.
Claim 5
Dependent Claim
22 words
A method as claimed in claim 1, characterized in that the pulse power of the inversion pulses exceeds a predetermined threshold value.
Claim 6
Dependent Claim
30 words
A method as claimed in claim 1, characterized in that the first type of nucleus is a 31 P phosphorous isotope, the second type of nucleus being 1 H hydrogen.
Claim 7
Dependent Claim
34 words
A method as claimed in claim 1, characterized in that the first type of nucleus is irradiated with a first surface coil, the second type of nucleus being irradiated with a second surface coil.
Claim 8
Dependent Claim
23 words
A method as claimed in claim 1, characterized in that the magnetic resonance signals are selected from a volume part of the object.
Claim 9
Independent Claim
204 words
A device for determining a spectrum from at least one magnetic resonance signal, which device comprises means for generating a steady, uniform magnetic field, first transmitter means for transmitting RF electromagnetic excitation pulses for exciting a first type of nucleus in an object, second transmitter means for transmitting inversion pulses to a second type of nucleus in the object, said second type of nucleus being spin-coupled to the first type of nucleus, in order to decouple the first type of nucleus from the second type of nucleus, receiver means for receiving resonance signals from the object, means for generating at least one magnetic field gradient, sampling means for sampling the magnetic resonance signal and display means for displaying the spectrum, and also comprises processing means which include programmed arithmetic means for determining the spectrum from sampling values obtained by means of the sampling means, the programmed means also being suitable for activating, at least during signal acquisition of the resonance signals, the second transmitter means in order to transmit the inversion pulses, characterized in that the programmed means are also suitable for controlling the second transmitter means so that the inversion pulses are pulses modulated in amplitude as well as in frequency or phase.
Claim 10
Independent Claim
204 words
A device for determining a spectrum from at least one magnetic resonance signal, which device comprises means for generating a steady, uniform magnetic field, first transmitter means for transmitting RF electromagnetic excitation pulses for exciting a first type of nucleus in an object, second transmitter means for transmitting inversion pulses to a second type of nucleus in the object, said second type of nucleus being spin-coupled to the first type of nucleus, in order to decouple the first type of nucleus from the second type of nucleus, receiver means for receiving resonance signals from the object, means for generating at least one magnetic field gradient, sampling means for sampling the magnetic resonance signal and display means for displaying the spectrum, and also comprises processing means which include programmed arithmetic means for determining the spectrum from sampling values obtained by means of the sampling means, the programmed means also being suitable for activating, at least during signal acquisition of the resonance signals, the second transmitter means in order to transmit the inversion pulses, characterized in that the programmed means are also suitable for controlling the second transmitter means so that the inversion pulses are pulses modulated in amplitude as well as in frequency or phase.
Claim 11
Dependent Claim
30 words
A method as claimed in claim 2, characterized in that the first type of nucleus is a 31 p phosphor isotope, the second type of nucleus being 1 H hydrogen.
Claim 12
Dependent Claim
30 words
A method as claimed in claim 3, characterized in that the first type of nucleus is a 31 P phosphorous isotope, the second type of nucleus being 1 H hydrogen.
Claim 13
Dependent Claim
30 words
A method as claimed in claim 4, characterized in that the first type of nucleus is a 31 P phosphorous isotope, the second type of nucleus being 1 H hydrogen.
Claim 14
Dependent Claim
34 words
A method as claimed in claim 2, characterized in that the first type of nucleus is irradiated with a first surface coil, the second type of nucleus being irradiated with a second surface coil.
Claim 15
Dependent Claim
34 words
A method as claimed in claim 3, characterized in that the first type of nucleus is irradiated with a first surface coil, the second type of nucleus being irradiated with a second surface coil.
Claim 16
Dependent Claim
34 words
A method as claimed in claim 9, characterized in that the first type of nucleus is irradiated with a first surface coil, the second type of nucleus being irradiated with a second surface coil.
Claim 17
Dependent Claim
34 words
A method as claimed in claim 10, characterized in that the first type of nucleus is irradiated with a first surface coil, the second type of nucleus being irradiated with a second surface coil.
Claim 18
Dependent Claim
23 words
A method as claimed in claim 2, characterized in that the magnetic resonance signals are selected from a volume part of the object.
Claim 19
Dependent Claim
23 words
A method as claimed in claim 3, characterized in that the magnetic resonance signals are selected from a volume part of the object.
Claim 20
Dependent Claim
23 words
A method as claimed in claim 5, characterized in that the magnetic resonance signals are selected from a volume part of the object.
Claim 21
Dependent Claim
23 words
A method as claimed in claim 14, characterized in that the magnetic resonance signals are selected from a volume part of the object.
Claim 22
Dependent Claim
23 words
A method as claimed in claim 15, characterized in that the magnetic resonance signals are selected from a volume part of the object.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1993-09-24 | 1994-03-26 | 1994-09-25 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1997-09-24 | 1998-03-26 | 1998-09-25 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2001-09-24 | 2002-03-26 | 2002-09-25 | $7700.00 | Window Closed / Lapsed |