US4956272A
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Organogermanium containing solution for washing and storing separated organs
Assignee: Asai Germanium Research Institute
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Filing: 1988-10-24
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Granted: 1990-09-11
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Expires: 2008-10-24
Abstract
Abstract The present invention provides (1) a solution for washing and storing separated organs, characterized by containing, as an effective component, an organogermanium compound represented by the formula (I) <IMAGE> (I) wherein R1 to R3 are each a hydrogen atom, a lower alkyl group such as methyl, ethyl or the like which may be the same or different, or a substituted or unsubstituted phenyl group, and X is a hydroxyl group, an O-lower alkyl group, an amino group or O-Y+(Y is a metal such as sodium, potassium or the like, or a basic group-containing compound such as lysozyme, basic amino acid or the like), and (2) a method for washing and storing separated organs with a solution containing, as an effective component, an organogermanium compound represented by the formula (I).
Inventors
- 👤 Norihiro Kakimoto
- 👤 Kazuo Kumano
- 👤 Kunie Nakamura
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-04 05:23
CPC Classifications
A; A01; A01N; A01N55/00; A01N55/02; A01N1/00; A01N1/10; A01N1/12; A01N1/122; A01N1/126
Claims Analysis
Total Claims: 18
Claim 1
Independent Claim
89 words
A solution for washing and storing separated organs, said solution comprising a hypertonic electrolyte solution and an effective washing and storing amount of an organogermanium compound represented by the formula (I): ##STR5## wherein R 1 to R 3 are each a hydrogen atom, a lower alkyl group which may be the same or different, or a substituted or unsubstituted phenyl group, and X is a hydroxyl group, an O-lower alkyl group, an amino group or O - Y + wherein Y is a metal or a basic group-containing compound.
Claim 2
Dependent Claim
89 words
A solution for washing and storing separated organs, said solution comprising a hypertonic electrolyte solution and an effective washing and storing amount of an organogermanium compound represented by the formula (I): ##STR5## wherein R 1 to R 3 are each a hydrogen atom, a lower alkyl group which may be the same or different, or a substituted or unsubstituted phenyl group, and X is a hydroxyl group, an O-lower alkyl group, an amino group or O - Y + wherein Y is a metal or a basic group-containing compound.
Claim 3
Dependent Claim
22 words
The solution according to claim 1, wherein the hypertonic electrolyte solution is an electrolyte solution having the same composition as intracellular fluid.
Claim 4
Dependent Claim
21 words
The solution according to claim 2, wherein the electrolyte solution having the same composition as intracellular fluid is a Collins solution.
Claim 5
Dependent Claim
22 words
The solution according to claim 2, wherein the electrolyte solution having the same composition as intracellular fluid is an Euro Collins solution.
Claim 6
Dependent Claim
36 words
The solution according to claim 2, wherein the electrolyte solution contains at least Na + , K + , Cl - , HCO 3 - , HPO 4 -- , H 2 PO 4 - .
Claim 7
Dependent Claim
25 words
The solution according to claim 1, wherein R 1 , R 2 and R 3 are a hydrogen atom and X is a hydroxyl group.
Claim 8
Dependent Claim
13 words
The solution according to claim 1, further comprising heparin, procaine, furosemide and mannitol.
Claim 9
Dependent Claim
18 words
The solution according to claim 1, wherein the lower alkyl group is a methyl or an ethyl group.
Claim 10
Dependent Claim
13 words
The solution according to claim 1, wherein the metal is sodium or potassium.
Claim 11
Dependent Claim
18 words
The solution according to claim 1, wherein the basic group is a lysozyme or a basic amino acid.
Claim 12
Independent Claim
105 words
A method for organ preservation comprising the steps of: (a) washing a separated organ with a solution comprising a crystalloid solution and an effective washing and storing amount of an organogermanium compound represented by the formula (I): ##STR6## wherein R 1 to R 3 are each a hydrogen atom, a lower alkyl group which may be the same or different, or a substituted or unsubstituted phenyl group, and X is a hydroxyl group, an O-lower alkyl group, an amino group or O - Y + wherein Y is a metal or a basic group containing compound; and (b) storing the separated organ in the solution.
Claim 13
Independent Claim
105 words
A method for organ preservation comprising the steps of: (a) washing a separated organ with a solution comprising a crystalloid solution and an effective washing and storing amount of an organogermanium compound represented by the formula (I): ##STR6## wherein R 1 to R 3 are each a hydrogen atom, a lower alkyl group which may be the same or different, or a substituted or unsubstituted phenyl group, and X is a hydroxyl group, an O-lower alkyl group, an amino group or O - Y + wherein Y is a metal or a basic group containing compound; and (b) storing the separated organ in the solution.
Claim 14
Dependent Claim
25 words
The method according to claim 11, wherein R 1 , R 2 and R 3 are a hydrogen atom and X is a hydroxyl group.
Claim 15
Dependent Claim
16 words
The method according to claim 11, wherein said solution further comprises heparin, procaine, furosemide and mannitol.
Claim 16
Dependent Claim
18 words
The method according to claim 11, wherein the lower alkyl group is a methyl or an ethyl group.
Claim 17
Dependent Claim
13 words
The method according to claim 11, wherein the metal is sodium or potassium.
Claim 18
Dependent Claim
18 words
The method according to claim 11, wherein the basic group is a lysozyme or a basic amino acid.
References Cited (Backward Citations)
US3689516A
Cited
US4066678A
Cited
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