Patent US4956173A successfully refreshed from Google Patents.
US4956173A
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Composition and use of ademetionine against ageing of the skin
Assignee: Elf Sanofi SA
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Filing: 1988-11-25
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Granted: 1990-09-11
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Expires: 2008-11-25
Abstract
Abstract The present invention relates to the use of ademetionine or one of its salts for the preparation of pharmaceutical or cosmetic compositions for counteracting ageing of the skin. It further relates to the said cosmetic compositions.
Inventors
- 👤 Gerard Le Fur
- 👤 Michele Bousquet
- 👤 Emilio Crisafulli
- 👤 Michel Sabadie
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 15:39
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/70; A61K8/00; A61K8/18; A61K8/30; A61K8/60; A61K8/606; A61Q; A61Q19/00; A61Q19/08
Claims Analysis
Total Claims: 23
Claim 1
Independent Claim
47 words
A method of treating the skin of a living human to counteract aging, which comprises applying to the skin a cosmetic or pharmaceutical preparation containing an effective amount of ademetionine or a salt thereof dissolved or dispersed in a cosmetically or pharmaceutically acceptable vehicle for topical administration.
Claim 2
Independent Claim
47 words
A method of treating the skin of a living human to counteract aging, which comprises applying to the skin a cosmetic or pharmaceutical preparation containing an effective amount of ademetionine or a salt thereof dissolved or dispersed in a cosmetically or pharmaceutically acceptable vehicle for topical administration.
Claim 3
Dependent Claim
21 words
The method of claim 1, wherein a salt of ademetionine is used, said salt being ademetionine disulfate di-p-toluenesulfonate or ademetionine disulfate.
Claim 4
Dependent Claim
22 words
The method of claim 1, wherein a salt of ademetionine is used, said salt being a salt of ademetionine with a polyanion.
Claim 5
Dependent Claim
21 words
The method of claim 3, wherein the said polyanion is selected from a cellulose sulfate, a chitin sulfate or chitosan 6-sulfate.
Claim 6
Dependent Claim
28 words
The method of claim 1, wherein said ademetionine or salt thereof is present in combination with a stabilizer selected from the group consisting of mannitol, lactose and maltose.
Claim 7
Dependent Claim
26 words
The method of claim 5, wherein said stabilizer is mannitol, and wherein the ratio of ademetionine or ademetionine salt to mannitol is about 3 to 1.
Claim 8
Dependent Claim
24 words
The method of claim 1, wherein said ademetionine or a salt thereof is applied in the form of a microemulsion prepared immediately before use.
Claim 9
Dependent Claim
27 words
The method of claim 1, wherein said ademetionine or a salt thereof is applied at a concentration in said vehicle of between 0.001 and 5% by weight.
Claim 10
Dependent Claim
25 words
The method of claim 8, wherein the concentration of said ademetionine or a salt thereof is between 0.001 and 1% by weight in said vehicle.
Claim 11
Dependent Claim
25 words
The method of claim 8, wherein the concentration of said ademetionine or a salt thereof is between 0.05 and 0.2% by weight in said vehicle.
Claim 12
Dependent Claim
50 words
A cosmetic composition, which comprises ademetionine or a salt thereof, dissolved or dispersed in a cosmetically acceptable vehicle for topical administration, said ademetionine or salt being contained in said composition in an amount sufficient to counteract ageing of the skin by maintaining fluidity of the membranes of the skin cells.
Claim 13
Dependent Claim
50 words
A cosmetic composition, which comprises ademetionine or a salt thereof, dissolved or dispersed in a cosmetically acceptable vehicle for topical administration, said ademetionine or salt being contained in said composition in an amount sufficient to counteract ageing of the skin by maintaining fluidity of the membranes of the skin cells.
Claim 14
Dependent Claim
11 words
The cosmetic composition of claim 11, which further comprises a stabilizer.
Claim 15
Dependent Claim
36 words
The cosmetic composition of claim 12, wherein said ademetionine or salt thereof is ademetionine disulfate di-p-toluenesulfonate, said stabilizer is mannitol, and the ratio of said ademetionine disulfate di-p-toluenesulfonate to said mannitol is about 3 to 1.
Claim 16
Dependent Claim
14 words
The composition of claim 11, wherein said ademetionine or salt thereof is ademetionine disulfate.
Claim 17
Dependent Claim
28 words
The composition of claim 11, wherein said ademetionine or a salt thereof is present in a concentration of 0.001 to 5% by weight in said cosmetically acceptable vehicle.
Claim 18
Dependent Claim
27 words
The cosmetic composition of claim 15, wherein said ademetionine or a salt thereof is present in said vehicle in a concentration of 0.001 to 1% by weight.
Claim 19
Dependent Claim
31 words
The method of claim 7, wherein said microemulsion further comprises a surfactant in an amount of 7 to 40%, said surfactant having a hydrophilic lipophilic balance of between 10 and 17.
Claim 20
Dependent Claim
18 words
The method of claim 17, wherein said surfactant has a hydrophilic lipophilic balance of between 11 and 15.
Claim 21
Dependent Claim
39 words
The cosmetic composition of claim 11, which further comprises an unsubstituted saturated or unsaturated fatty acid containing 1 to 18 carbons, a hydroxy saturated or unsaturated fatty acid containing 1 to 18 carbons, or an alkali metal salt thereof.
Claim 22
Dependent Claim
16 words
The cosmetic composition of claim 12, wherein said ademetionine or a salt thereof is ademetionine disulfate.
Claim 23
Dependent Claim
27 words
The cosmetic composition of claim 16, wherein said ademetionine or a salt thereof is present in said vehicle in a concentration of 0.05 to 0.2% by weight.
References Cited (Backward Citations)
FR2275220A1
Cited
US4057686A
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Cited
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Cited
EP0108817A1
Cited
CA1218986A
Cited
EP0148057A2
Cited
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Cited
WO1989003389A1
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 1993-09-10 | 1994-03-12 | 1994-09-11 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1997-09-10 | 1998-03-12 | 1998-09-11 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2001-09-10 | 2002-03-12 | 2002-09-11 | $7700.00 | Window Closed / Lapsed |