US4954625A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Piperidine derivatives, their production and use
Assignee: Takeda Pharmaceutical Co Ltd
•
Filing: 1989-08-30
•
Granted: 1990-09-04
•
Expires: 2009-08-30
Abstract
Abstract Novel compounds of the formula: ##STR1## [wherein A is an α-amino acid residue; B is a group represented by the formula: ##STR2## wherein R 4 is hydrogen, lower alkyl, aralkyl or amino-lower alkyl), whereby the linkage between the symbols A and B designates a peptide bond and the group R 4 in B may be linked with A; R 1 is hydrogen, lower alkyl or aralkyl; R 2 is hydrogen, lower alkyl, aralkyl or acyl; X is alkylene] and salts thereof posses, for example, inhibitory activity on angiotensin converting enzyme, and are useful as an agent for diagnosis, prevention or treatment of hypertension as well as circulatory diseases such as cardiopathy and cerebral apoplexy.
Inventors
- 👤 Hirosada Sugihara
- 👤 Kohei Nishikawa
- 👤 Katsumi Ito
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-05 19:53
CPC Classifications
C; C07; C07K; C07K5/00; C07K5/02; C07K5/022; C07K5/0222; A; A61; A61K; A61K38/00
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
52 words
A compound of the formula: ##STR173## wherein A--B is a group represented by the formula: ##STR174## wherein R 3 is hydrogen, lower alkyl or aralkyl; R 1 is hydrogen, lower alkyl or aralyl; R 2 is hydrogen, lower alkyl, aralkyl, or acyl; and X is alkylene; or a pharmaceutically acceptable salt thereof.
Claim 2
Dependent Claim
52 words
A compound of the formula: ##STR173## wherein A--B is a group represented by the formula: ##STR174## wherein R 3 is hydrogen, lower alkyl or aralkyl; R 1 is hydrogen, lower alkyl or aralyl; R 2 is hydrogen, lower alkyl, aralkyl, or acyl; and X is alkylene; or a pharmaceutically acceptable salt thereof.
Claim 3
Dependent Claim
14 words
A compound according to claim 1, wherein R 1 is hydrogen or lower alkyl.
Claim 4
Dependent Claim
11 words
A compound according to claim 1, wherein R 2 is hydrogen.
Claim 5
Dependent Claim
12 words
A compound according to claim 1, wherein R 3 is lower alkyl.
Claim 6
Dependent Claim
13 words
A compound according to claim 1, wherein X is trimethylene, tetramethylene or pentamethylene.
Claim 7
Dependent Claim
10 words
A compound according to claim 1, wherein X is tetramethylene.
Claim 8
Dependent Claim
11 words
A compound according to claim 1, wherein R 1 is hydrogen.
Claim 9
Dependent Claim
12 words
A compound according to claim 1, wherein said compound is ter-butyl 3(S)-[5-(1-benzyloxycarbonyl-4-piperidyl)-(S)-ethoxy-carbonylpentyl]amino-2-oxo-2,3,4,5-tetrahydro-1H-1-benzazepine-1-acetate.
Claim 10
Dependent Claim
49 words
A compound according to claim 1, wherein R 3 is hydrogen, lower alkyl or phenyl-lower alkyl; R 1 is hydrogen, lower alkyl or phenyl-lower alkyl; R 2 is hydrogen, lower alkyl, phenyl-lower alkyl, lower alkanoyl, benzoyl, phenyl-lower alkoxy carbonyl or lower alkoxy carbonyl; and X is C 1-7 alkylene.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1993-09-03 | 1994-03-05 | 1994-09-04 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1997-09-03 | 1998-03-05 | 1998-09-04 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2001-09-03 | 2002-03-05 | 2002-09-04 | $7700.00 | Window Closed / Lapsed |