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US4591458A Expired / Lapsed US ⏱️ 0.0 years remaining

3-amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzoxazepine derivatives

Assignee: Takeda Pharmaceutical Co Ltd
•
Filing: 1985-07-26
•
Granted: 1986-05-27
•
Expires: 2005-07-26
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Abstract

Abstract Novel 3-amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzoxazepine derivatives of the formula ##STR1## [wherein R 1 and R 2 are independently hydrogen, halogen trifluoromethyl, lower alkyl or lower alkoxy, or both jointly form tri- or tetramethylene; R 3 is hydrogen, optionally substituted lower alkyl or optionally substituted aralkyl; R 4 is hydrogen, optionally substituted alkyl, optionally substituted aralkyl or optionally substituted cycloalkylalkyl; Y is a carboxyl group which may be esterified or amidated; m is 1 or 2] and salts thereof. These compounds and salts thereof exhibits inhibitory activity on angiotensin converting enzyme and so forth, and are of value as an agent for diagnosis, prevention and treatment of circulatory diseases (e.g. hypertension, cardiopathy, cerebral apoploxy).

Inventors

  • 👤 Hirosada Sugihara
  • 👤 Kohei Nishikawa
  • 👤 Katsumi Ito

Bibliographic Details

Application Number —
Jurisdiction US
Data Source google_patents
Last Synchronized 2026-11-06 14:09
CPC Classifications
C; C07; C07D; C07D413/00; C07D413/02; C07D413/12; A; A61; A61P; A61P43/00; A61P9/00; A61P9/12; C07D211/00; C07D211/04; C07D211/06; C07D211/08; C07D211/18; C07D211/20; C07D211/22; C07D211/34; C07D213/00; C07D213/02; C07D213/04; C07D213/24; C07D213/54; C07D213/55; C07D267/00; C07D267/02; C07D267/08; C07D267/12; C07D267/14; C07D309/00; C07D309/02; C07D309/08; C07D335/00; C07D335/02; C07K; C07K5/00; C07K5/02; C07K5/022; C07K5/0222; A61K; A61K38/00; Y; Y02; Y02P; Y02P20/00; Y02P20/50; Y02P20/55

Claims Analysis

Total Claims: 8
Claim 1
Independent Claim 8 words
3(S)-[8-Amino-1(S)-ethoxycarbonyloctyl]amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzoxazepine-5-acetic acid or a pharmaceutically acceptable salt thereof.
Claim 2
Dependent Claim 8 words
3(S)-[8-Amino-1(S)-ethoxycarbonyloctyl]amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzoxazepine-5-acetic acid or a pharmaceutically acceptable salt thereof.
Claim 3
Dependent Claim 8 words
3(S)-[8-Amino-1(S)-carboxyoctyl]amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzoxazepine-5-acetic acid or a pharmaceutically acceptable salt thereof.
Claim 4
Dependent Claim 8 words
3(S)-[8-Amino-1(S)-carboxyoctyl]amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzoxazepine-5-acetic acid or a pharmaceutically acceptable salt thereof.
Claim 5
Dependent Claim 8 words
3(S)-[7-Amino-1(S)-ethoxycarbonylheptyl]amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzoxazepine-5-acetic acid or a pharmaceutically acceptable salt thereof.
Claim 6
Dependent Claim 8 words
3(S)-[7-Amino-1(S)-ethoxycarbonylheptyl]amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzoxazepine-5-acetic acid or a pharmaceutically acceptable salt thereof.
Claim 7
Dependent Claim 8 words
3(S)-[7-Amino-1(S)-carboxyheptyl]amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzoxazepine-5-acetic acid or a pharmaceutically acceptable salt thereof.
Claim 8
Dependent Claim 8 words
3(S)-[7-Amino-1(S)-carboxyheptyl]amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzoxazepine-5-acetic acid or a pharmaceutically acceptable salt thereof.

References Cited (Backward Citations)

US4477464A Cited

USPTO Annuity & Maintenance Windows

Annuity Stage Window Opens Payment Deadline Surcharge Period Until Estimated Fee Status
3.5 Years (Year 4) 1989-05-26 1989-11-25 1990-05-27 $2000.00 Window Closed / Lapsed
7.5 Years (Year 8) 1993-05-26 1993-11-25 1994-05-27 $3760.00 Window Closed / Lapsed
11.5 Years (Year 12) 1997-05-26 1997-11-25 1998-05-27 $7700.00 Window Closed / Lapsed

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