Patent US1848877A successfully refreshed from Google Patents.
Patent US4948799A successfully refreshed from Google Patents.
US4948799A
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US
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Imide derivatives, and their use in pharmaceuticals
Assignee: Sumitomo Pharma Co Ltd
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Filing: 1989-01-04
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Granted: 1990-08-14
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Expires: 2009-01-04
Abstract
Abstract An imide derivative of the formula: <CHEM> or its salt, useful as an antipsychotic drug.
Inventors
- 👤 Fujio Antoku
- 👤 Mayumi Yoshigi
- 👤 Ikutaro Saji
- 👤 Atsuyuki Kojima
- 👤 Kukuo Ishizumi
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 16:18
CPC Classifications
C; C07; C07D; C07D401/00; C07D401/02; C07D401/06; A; A61; A61P; A61P25/00; A61P25/18; C07D211/00; C07D211/04; C07D211/80; C07D211/84; C07D211/86; C07D211/88; C07D417/00; C07D417/02; C07D417/06; C07D417/14
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
186 words
A compound of the formula: ##STR187## wherein A is a carbonyl group; B is a group of the formula: ##STR188## (in which R 11 and R 12 are each lower alkyl group, or they are combined together to form a lower alkylene group; W is trimethylene, propylene, tetramethylene, 2-methyltrimethylene or 2-methyltetramethylene, or a lower alkenylene group, a lower alkynylene group or a lower alkylene group substituted with hydroxyl; and G is a benzoisothiazolyl group, a benzoisothiazolyl group substituted with a member selected from the group consisting of lower alkyl, lower alkoxy, halogen and halogenated lower alkyl or a group of the formula: ##STR189## (in which Y is an oxygen atom, a carbonyl group, a methylene group, a group of the formula: ##STR190## (in which m is an integer of 0, 1 or 2), a group of the formula: ##STR191## (in which R 13 is a hydrogen atom, a lower alkyl group or a lower alkanoyl group) or a group of the formula: ##STR192## and Z is a hydrogen atom, a halogen atom, a lower alkyl group or a lower alkoxy group), or its pharmaceutically acceptable salt.
Claim 2
Dependent Claim
186 words
A compound of the formula: ##STR187## wherein A is a carbonyl group; B is a group of the formula: ##STR188## (in which R 11 and R 12 are each lower alkyl group, or they are combined together to form a lower alkylene group; W is trimethylene, propylene, tetramethylene, 2-methyltrimethylene or 2-methyltetramethylene, or a lower alkenylene group, a lower alkynylene group or a lower alkylene group substituted with hydroxyl; and G is a benzoisothiazolyl group, a benzoisothiazolyl group substituted with a member selected from the group consisting of lower alkyl, lower alkoxy, halogen and halogenated lower alkyl or a group of the formula: ##STR189## (in which Y is an oxygen atom, a carbonyl group, a methylene group, a group of the formula: ##STR190## (in which m is an integer of 0, 1 or 2), a group of the formula: ##STR191## (in which R 13 is a hydrogen atom, a lower alkyl group or a lower alkanoyl group) or a group of the formula: ##STR192## and Z is a hydrogen atom, a halogen atom, a lower alkyl group or a lower alkoxy group), or its pharmaceutically acceptable salt.
Claim 3
Dependent Claim
18 words
The compound according to claim 1, wherein R 11 and R 12 are each a lower alkyl group.
Claim 4
Dependent Claim
42 words
The compound according to claim 1, wherein W is tetramethylene or either one of the following groups: --CH 2 CH═CHCH 2 --, --CH 2 C═CCH 2 , --CH 2 CH(OH)CH 2 CH 2 -- and --CH 2 CH 2 CH(OH)CH 2 --.
Claim 5
Dependent Claim
64 words
The compound according to claim 1, wherein G is a group of the formula: ##STR193## (in which Y is a carbonyl group and Z is a halogen atom, a lower alkyl group or a lower alkoxy group), or a benzoisothiazolyl group or a benzoisothiazolyl group substituted with a member selected from the group consisting of lower alkyl, lower alkoxy, halogen and halogenated lower alkyl.
Claim 6
Dependent Claim
59 words
The compound according to claim 1, wherein B is a group of the formula: ##STR194## (in which R 11 and R 12 are each a lower alkyl group), W is a lower alkyl group, W is tetramethylene and G is a group of the formula: ##STR195## (in which Y is a carbonyl group and Z is a halogen atom).
Claim 7
Dependent Claim
46 words
The compound according to claim 1, wherein said pharmaceutically acceptable salt is a salt with an acid selected from the group consisting of hydrochloric acid, hydrobromic acid, hydroiodic acid, sulfuric acid, acetic acid, oxalic acid, citric acid malic acid, maleic acid, tartaric acid, and fumaric acid.
Claim 8
Dependent Claim
38 words
A pharmaceutical composition for the treatment of psychosis which comprises as an active ingredient a pharmaceutically effective amount of at least one compound as claimed in claim 1, and at least one pharmaceutically acceptable inert carrier or diluent.
Claim 9
Dependent Claim
30 words
A method for the treatment of psychosis which comprises administering to a person suffering from psychosis a pharmaceutically effective amount of at least one compound as claimed in claim 1.
References Cited (Backward Citations)
US3106552A
Cited
US3171839A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1993-08-13 | 1994-02-12 | 1994-08-14 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1997-08-13 | 1998-02-12 | 1998-08-14 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2001-08-13 | 2002-02-12 | 2002-08-14 | $7700.00 | Window Closed / Lapsed |