US4943560A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Solvent system for chronic vascular infusion of hydrophobic drugs
Assignee: University of Minnesota System
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Filing: 1988-04-06
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Granted: 1990-07-24
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Expires: 2008-04-06
Abstract
Abstract The present invention provides a liquid infusate for the chronic vascular infusion of a hydrophobic biologically-active compound, such as cyclosporin, comprising a solution of a therapeutically-effective amount of the biologically-active compound in a mixture of about 10-80% glycerol and about 90-20% ethanol, by volume.
Inventors
- 👤 Bruce D. Wigness
- 👤 Thomas D. Rohde
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 05:56
CPC Classifications
A; A61; A61K; A61K38/00; A61K38/04; A61K38/12; A61K38/13; A61K47/00; A61K47/06; A61K47/08; A61K47/10; A61K9/00; A61K9/0012; A61K9/0019
Claims Analysis
Total Claims: 4
Claim 1
Independent Claim
37 words
A liquid infusate for the chronic vascular infusion of a hydrophobic biologically-active compound comprising a solution of therapeutically-effective amount of a cyclosporin in a solvent consisting essentially of about 10-80% glycerol and about 90-20% ethanol, by volume.
Claim 2
Dependent Claim
37 words
A liquid infusate for the chronic vascular infusion of a hydrophobic biologically-active compound comprising a solution of therapeutically-effective amount of a cyclosporin in a solvent consisting essentially of about 10-80% glycerol and about 90-20% ethanol, by volume.
Claim 3
Dependent Claim
11 words
The infusate of claim 1 which is free of nonionic surfactants.
Claim 4
Dependent Claim
11 words
The infusate of claim 1 which contains about 25-500 mg/ml cyclosporin.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1993-07-23 | 1994-01-22 | 1994-07-24 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1997-07-23 | 1998-01-22 | 1998-07-24 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2001-07-23 | 2002-01-22 | 2002-07-24 | $7700.00 | Window Closed / Lapsed |