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US4933472A
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Substituted aminomethylenebis(phosphonic acid) derivatives
Assignee: Astellas Pharma Inc
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Filing: 1989-04-05
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Granted: 1990-06-12
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Expires: 2009-04-05
Abstract
Abstract Substituted aminomethylenebis(phosphonic acid) derivatives represented by the general formula: ##STR1## in which R 1 , R 2 R 3 and R 4 may be the same or different, each represents a hydrogen atom or a lower alkyl group; "m" is zero or represents an integer from 1 to 4; and a ring "A" represents a cycloalkenyl group having 5 to 8 carbon atoms, a bicycloheptyl group, a bicycloheptenyl group or a saturated heterocyclic group having 4 to 7 carbon atoms and containing an oxygen atom, a sulfur atom, a sulfinyl group (--SO--) or a sulfonyl group (--SO 2 --), or pharmaceutically acceptable salts thereof.
Inventors
- 👤 Yasuo Isomura
- 👤 Makoto Takeuchi
- 👤 Shuichi Sakamoto
- 👤 Tetsushi Abe
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-29 19:00
CPC Classifications
C; C07; C07F; C07F9/00; C07F9/02; C07F9/547; C07F9/6553; C07F9/655363; C07F9/28; C07F9/38; C07F9/3804; C07F9/3839; C07F9/3873; C07F9/40; C07F9/4003; C07F9/4025; C07F9/405; C07F9/655
Claims Analysis
Total Claims: 5
Claim 1
Independent Claim
105 words
Substituted aminomethylenebis(phosphonic acid) derivatives represented by the general formula: ##STR40## in which R 1 , R 2 , R 3 and R 4 may be the same or different, each represents a hydrogen atom or a lower alkyl group; "m" is zero or represents an integer from 1 to 4; and a ring "A" represents a cycloalkenyl group having 5 to 8 carbon atoms, a bicycloheptyl group, a bicycloheptenyl group or a saturated heterocyclic group having 4 to 7 carbon atoms and containing an oxygen atom, a sulfur atom, a sulfinyl group (--SO--) or a sulfonyl group (--SO 2 --), or pharmaceutically acceptable salts thereof.
Claim 2
Dependent Claim
105 words
Substituted aminomethylenebis(phosphonic acid) derivatives represented by the general formula: ##STR40## in which R 1 , R 2 , R 3 and R 4 may be the same or different, each represents a hydrogen atom or a lower alkyl group; "m" is zero or represents an integer from 1 to 4; and a ring "A" represents a cycloalkenyl group having 5 to 8 carbon atoms, a bicycloheptyl group, a bicycloheptenyl group or a saturated heterocyclic group having 4 to 7 carbon atoms and containing an oxygen atom, a sulfur atom, a sulfinyl group (--SO--) or a sulfonyl group (--SO 2 --), or pharmaceutically acceptable salts thereof.
Claim 3
Dependent Claim
21 words
The substituted aminomethylenebis(phosphonic acid) derivative or pharmaceutically acceptable salt thereof set forth in claim 1, wherein said derivative is (2,3,4,5-tetrahydro-2-furfuryl)aminomethylenebis(phosphonic acid).
Claim 4
Dependent Claim
21 words
The substituted aminomethylenebis(phosphonic acid) derivative or pharmaceutically acceptable salt thereof set forth in claim 1, wherein said derivative is (2-bicyclo-[2.2.1]-heptyl)aminomethylenebis(phosphonic acid).
Claim 5
Dependent Claim
21 words
The substituted aminomethylenebis(phosphonic acid) derivative or pharmaceutically acceptable salt thereof set forth in claim 1, wherein said derivative is (2-cycloheptenyl)aminomethylenebis(phosphonic acid).
References Cited (Backward Citations)
JPS5437829A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1993-06-11 | 1993-12-11 | 1994-06-12 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1997-06-11 | 1997-12-11 | 1998-06-12 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2001-06-11 | 2001-12-11 | 2002-06-12 | $7700.00 | Window Closed / Lapsed |