US4925924A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Biocompatible synthetic and collagen compositions having a dual-type porosity for treatment of wounds and pressure ulcers and therapeutic methods thereof
Assignee: Rutgers Health
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Filing: 1987-10-26
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Granted: 1990-05-15
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Expires: 2007-10-26
Abstract
Abstract A therapeutic method for treating pressure ulcers like decubitus ulcers with biodegradable collagen flake compositions and with biodegradable collagen sponge or sponge-like compositions. The products of the invention includes biodegradable collagen flake compositions and biodegradable collagen sponge or sponge-like compositions. The products are useful for medical applications, like skin reconstruction, treatment of wounds, especially deep wounds, also in connection with surgery, including cosmetic surgery. The invention also deals with biocompatible synthetic resin sponge or sponge-like and flake products for medical and similar applications. The invention contemplates the treatment of human and animal species.
Inventors
- 👤 Frederick H. Silver
- 👤 Richard A. Berg
- 👤 charles J. Doillon
- 👤 Arkady Chernomorsky
- 👤 Robert M. Olson
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 17:34
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/70; A61L; A61L15/00; A61L15/16; A61L15/22; A61L15/32; A61L15/325; A61L15/42; A61L15/425; A61L15/44; A61L15/64; A61L26/00; A61L26/0009; A61L26/0028; A61L26/0033; A61L27/00; A61L27/14; A61L27/22; A61L27/24; A61L27/50; A61L27/56; A61L27/58; C; C08; C08L; C08L89/00; C08L89/04; C08L89/06; A61L2300/00; A61L2300/20; A61L2300/252; A61L2300/40; A61L2300/412
Claims Analysis
Total Claims: 26
Claim 1
Independent Claim
56 words
A collagen product comprising a porous mass of slices of porous collagen fibers, the porous mass having a dualtype porosity of channels and pores in which the channels form a labyrinthal-type structure extending between the slices and individual fibers, with some channels extending throughout the product, and in which the pores are contained in the fibers.
Claim 2
Dependent Claim
56 words
A collagen product comprising a porous mass of slices of porous collagen fibers, the porous mass having a dualtype porosity of channels and pores in which the channels form a labyrinthal-type structure extending between the slices and individual fibers, with some channels extending throughout the product, and in which the pores are contained in the fibers.
Claim 3
Dependent Claim
21 words
The collagen product of claim 1 which is dimensionally stable but wherein the slices are slidable with respect to each other.
Claim 4
Dependent Claim
11 words
The collagen product of claim 1 which is a crosslinked collagen.
Claim 5
Dependent Claim
14 words
The collagen product of claim 1 which is a collagen which is not cross-linked.
Claim 6
Dependent Claim
9 words
The collagen product of claim 1 which is dehydrated.
Claim 7
Dependent Claim
17 words
The collagen product of claim 5 which has a moisture content not exceeding about 15% by weight.
Claim 8
Dependent Claim
9 words
The collagen product of claim 5 which is sterile.
Claim 9
Dependent Claim
17 words
The sterile collagen product of claim 7 wherein the collagen product is sealed in a plastic bag.
Claim 10
Dependent Claim
21 words
A wound dressing especially for decubitus ulcers which comprises a moisture vapor diffusion layer and the collagen product of claim 1.
Claim 11
Dependent Claim
93 words
A therapeutic method for treatment of wounds of a patient which comprises packing the wound with a porous mass of slices of porous collagen fibers, the porous mass having dual-type porosity of channels and pores in which the channels extend between the slices and individual fibers, with some channels extending throughout the product, and in which the pores are contained in the fibers, whereby the healing of the wound is promoted by fibroblast movement into the channels and pores, attachment of collagen inside the channels and new tissue is formed in the wound.
Claim 12
Dependent Claim
93 words
A therapeutic method for treatment of wounds of a patient which comprises packing the wound with a porous mass of slices of porous collagen fibers, the porous mass having dual-type porosity of channels and pores in which the channels extend between the slices and individual fibers, with some channels extending throughout the product, and in which the pores are contained in the fibers, whereby the healing of the wound is promoted by fibroblast movement into the channels and pores, attachment of collagen inside the channels and new tissue is formed in the wound.
Claim 13
Dependent Claim
16 words
The therapeutic method of claim 10 wherein the packing of the wound is carried out periodically.
Claim 14
Dependent Claim
13 words
The therapeutic method of claim 10 wherein the wound is a pressure wound.
Claim 15
Dependent Claim
12 words
The therapeutic method of claim 12 wherein the wound is an ulcer.
Claim 16
Dependent Claim
16 words
The therapeutic method of claim 13 wherein the ulcer is a stage 2 or 3 ulcer.
Claim 17
Dependent Claim
12 words
The therapeutic method of claim 14 wherein the ulcer is decubitus ulcer.
Claim 18
Dependent Claim
89 words
A process for making a collagen product of a porous mass of slices of porous collagen fibers, the porous mass having a dual-type porosity of channels and pores in which the channels extend between the slices and individual fibers, with some channels extending throughout the product, and in which the pores are contained in the fiber said process comprising shearing a biodegradable collagen porous sponge-like material into slices while minimizing application of pressure on the sponge-like product during shearing, and separating the slices, thereby forming the mass of slices.
Claim 19
Dependent Claim
89 words
A process for making a collagen product of a porous mass of slices of porous collagen fibers, the porous mass having a dual-type porosity of channels and pores in which the channels extend between the slices and individual fibers, with some channels extending throughout the product, and in which the pores are contained in the fiber said process comprising shearing a biodegradable collagen porous sponge-like material into slices while minimizing application of pressure on the sponge-like product during shearing, and separating the slices, thereby forming the mass of slices.
Claim 20
Dependent Claim
12 words
The process of claim 16 wherein the sponge-like material is a sponge.
Claim 21
Dependent Claim
23 words
The process of claim 16 wherein the shearing process is carried out concurrently with, prior to, or following cross-linking of the sponge-like material.
Claim 22
Dependent Claim
23 words
The process of claim 16 wherein the shearing process is carried out at a temperature range from about 1° to about 60° C.
Claim 23
Dependent Claim
19 words
The process of claim 16 wherein the shearing process is carried out at a temperature of about 20° C.
Claim 24
Dependent Claim
15 words
The process of claim 16 wherein the shearing process is carried out under atmospheric conditions.
Claim 25
Dependent Claim
15 words
The process of claim 16 wherein the shearing process is carried out under a vacuum.
Claim 26
Dependent Claim
15 words
The process of claim 16 wherein the shearing process is carried out in dry air.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1993-05-14 | 1993-11-13 | 1994-05-15 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1997-05-14 | 1997-11-13 | 1998-05-15 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2001-05-14 | 2001-11-13 | 2002-05-15 | $7700.00 | Window Closed / Lapsed |