Patent US4923871A successfully refreshed from Google Patents.
US4923871A
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US
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Certain 2,6-dimethyl-4-(pyrazolo[1,5a]-pyridin-3-yl)1,4-dihydro-pyridine-3,5-dicarboxylate derivatives and compositions containing same
Assignee: JAPANESE FOUNDATION FOR CANCER RESEARCH 1-37-1 KAMIIKEBUKRO TOSHIMA-KU TOKYO JAPAN A CORP OF JAPAN
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Filing: 1987-11-25
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Granted: 1990-05-08
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Expires: 2007-11-25
Abstract
Abstract This invention relates to new and useful 2,6-dimethyl-4-(pyrazolo[1,5-a]pyridin-3-yl)-1,4-dihydropyridine-3,5-d icarboxylate derivatives of the following formula: <IMAGE> and pharmaceutically acceptable salts thereof, having potent promoting activity of some antitumor agents against various kinds of tumor cells including multiple drug resistant tumor cells.
Inventors
- 👤 Makoto Inaba
- 👤 Hirotaka Shinoda
- 👤 Fujio Iinuma
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 16:11
CPC Classifications
C; C07; C07D; C07D471/00; C07D471/02; C07D471/04; A; A61; A61P; A61P35/00
Claims Analysis
Total Claims: 4
Claim 1
Independent Claim
35 words
A compound selected from the group consisting of dimethyl 2,6-dimethyl-4-(2-isopropylpyrazolo[1,5-a]pyridin-3-yl)-1,4-dihydropyridine-3,5-dicarboxylate; methyl ethyl 2,6-dimethyl-4-(2-isopropylpyrazolo-[1,5-a]pyridin-3-yl)-1,4-dihydropyridine-3,5-dicarboxylate; butyl methyl 2,6-dimethyl-4-(2-isopropylpyrazolo-[1,5-a]pyridin-3-yl)-1,4-dihydropyridine-3,5-dicarboxylate; tert-butyl methyl 2,6-dimethyl-4-(2-isopropylpyrazolo-[1,5-a]pyridin-3-yl)-1,4-dihydropyridine-3,5-dicarboxylate; methyl octyl 2,6-dimethyl-4-(2-isopropylpyrazolo-[1,5-a]pyridin-3-yl)-1,4-dihydropyridine-3,5-dicarboxylate; N-benzyl-N-methyl-2-aminoethyl methyl 2,6-dimethyl-4-(2-isopropylpyrazolo-[1,5-a]pyridin-3-yl)-1,4-dihydropyridine-3,5-dicarboxylate; methyl 2-dimethylaminoethyl 2,6-dimethyl-4-(2-isopropylpyrazolo-[1,5-a]pyridin-3-yl)-1,4-dihydropyridine-3,5-dicarboxylate; methyl 2-(4-methyl-1-piperazinyl)ethyl 2,6-dimethyl-4-(2-isopropylpyrazolo-[1,5-a]pyridin-3-yl)-1,4-dihydropyridine-3,5-dicarboxylate; and methyl 2-(N-benzyl-N-methylamino)ethyl 2,6-dimethyl-4-(2-isopropylpyrazolo-[1,5-a]pyridin-3-yl)-1,4-dihydropyridine-3,5-dicarboxylate.
Claim 2
Dependent Claim
35 words
A compound selected from the group consisting of dimethyl 2,6-dimethyl-4-(2-isopropylpyrazolo[1,5-a]pyridin-3-yl)-1,4-dihydropyridine-3,5-dicarboxylate; methyl ethyl 2,6-dimethyl-4-(2-isopropylpyrazolo-[1,5-a]pyridin-3-yl)-1,4-dihydropyridine-3,5-dicarboxylate; butyl methyl 2,6-dimethyl-4-(2-isopropylpyrazolo-[1,5-a]pyridin-3-yl)-1,4-dihydropyridine-3,5-dicarboxylate; tert-butyl methyl 2,6-dimethyl-4-(2-isopropylpyrazolo-[1,5-a]pyridin-3-yl)-1,4-dihydropyridine-3,5-dicarboxylate; methyl octyl 2,6-dimethyl-4-(2-isopropylpyrazolo-[1,5-a]pyridin-3-yl)-1,4-dihydropyridine-3,5-dicarboxylate; N-benzyl-N-methyl-2-aminoethyl methyl 2,6-dimethyl-4-(2-isopropylpyrazolo-[1,5-a]pyridin-3-yl)-1,4-dihydropyridine-3,5-dicarboxylate; methyl 2-dimethylaminoethyl 2,6-dimethyl-4-(2-isopropylpyrazolo-[1,5-a]pyridin-3-yl)-1,4-dihydropyridine-3,5-dicarboxylate; methyl 2-(4-methyl-1-piperazinyl)ethyl 2,6-dimethyl-4-(2-isopropylpyrazolo-[1,5-a]pyridin-3-yl)-1,4-dihydropyridine-3,5-dicarboxylate; and methyl 2-(N-benzyl-N-methylamino)ethyl 2,6-dimethyl-4-(2-isopropylpyrazolo-[1,5-a]pyridin-3-yl)-1,4-dihydropyridine-3,5-dicarboxylate.
Claim 3
Dependent Claim
21 words
A pharmaceutical composition comprising an antitumor activity promoting effective amount of the compound of claim 1 and a pharmaceutically acceptable carrier.
Claim 4
Dependent Claim
41 words
The composition of claim 1 wherein the compound is selected from the group consisting of dimethyl 2,6-dimethyl-4-(2-isopropylpyrazolo[1,5-a]-pyridin-3-yl)-1,4-dihydropyridine-3,5-dicarboxylate; methyl ethyl 2,6-dimethyl-4-(2-isopropylpyrazolo-[1,5-a]pyridin-3-yl)-1,4-dihydropyridine-3,5-dicarboxylate; butyl methyl 2,6-dimethyl-4-(2-isopropylpyrazolo-[1,5-a]pyridin-3-yl)-1,4-dihydropyridine-3,5-dicarboxylate; tert-butyl methyl 2,6-dimethyl-4-(2-isopropylpyrazolo-[1,5-a]pyridin-3-yl)-1,4-dihydropyridine-3,5-dicarboxylate; methyl octyl 2,6-dimethyl-4-(2-isopropylpyrazolo-[1,5-a]pyridin-3-yl)-1,4-dihydropyridine-3,5-dicarboxylate; N-benzyl-N-methyl-2-aminoethyl methyl 2,6-dimethyl-4-(2-isopropylpyrazolo-[1,5-a]pyridin-3-yl)-1,4-dihydropyridine-3,5-dicarboxylate; methyl 2-dimethylaminoethyl 2,6-dimethyl-4-(2-isopropylpyrazolo-[1,5-a]pyridin-3yl)-1,4-dihydropyridine-3,5-dicarboxylate; methyl 2-(4-methyl-1-piperazinyl)ethyl 2,6-dimethyl-4-(2-isopropylpyrazolo-[1,5-a]pyridin-3-yl)-1,4-dihydropyridine-3,5-dicarboxylate; methyl 2-(N-benzyl-N-methylamino)ethyl 2,6-dimethyl-4-(2-isopropylpyrazolo-[1,5-a]pyridin-3-yl)-1,4-dihydropyridine-3,5-dicarboxylate.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1993-05-07 | 1993-11-06 | 1994-05-08 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1997-05-07 | 1997-11-06 | 1998-05-08 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2001-05-07 | 2001-11-06 | 2002-05-08 | $7700.00 | Window Closed / Lapsed |