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US4920123A Expired / Lapsed US ⏱️ 0.0 years remaining

Method for controlling and/or lowering serum triglyceride and/or cholesterol levels in mammals

Assignee: Individual
•
Filing: 1988-10-21
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Granted: 1990-04-24
•
Expires: 2008-10-21
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Abstract

Abstract The use of at least one compound of Formula (I) for the manufacture of a medicament for controlling and/or reducing a patient's serum cholesterol and/or triglyceride level is disclosed. <CHEM> wherein Y is O or NH, R is OH, NHCONR<4>R<5>; or N=C(NR<4>R<5>)2;where R<4> and R<5> are each independently selected from the group consisting of hydrogen; C1-10alkyl, straight or branched chain; aryl C1-4alkyl; mono- or disubstituted aryl C1-4 alkyl where the substituents are fluoro, chlore, bromo, iodo, or C1-10alkyl, straight or branched chain; R<1> and R<2> are each independently selected from the group consisting of hydrogen, animo, and mono- or di-substituted amino where the substituents are C1-10alkyl, straight or branched chain, C3-8 cycloalkyl; provided that R<1> and R<2> may not both be amino or substituted amino and; R<3> is hydrogen, trifluoromethyl, fluoro; chloro, bromo, or iodo, or a pharmaceutically acceptable salt thereof. e

Inventors

  • 👤 Karl H. Beyer, Jr.

Bibliographic Details

Application Number —
Jurisdiction US
Data Source google_patents
Last Synchronized 2026-10-26 00:24
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/33; A61K31/395; A61K31/495; A61P; A61P3/00; A61P3/06

Claims Analysis

Total Claims: 7
Claim 1
Independent Claim 167 words
A method for controlling or lowering a patient's serum cholesterol concentration, comprising administering to a patient an effective amount of a compound of the formula (I) ##STR5## wherein Y is O or NH, R is OH, NHCONR 4 R 5 ; or N═C(NR 4 R 5 ) 2 ; where R 4 and R 5 are each independently selected from the group consisting of hydrogen; C 1-10 alkyl, straight or branched chain; aryl C 1-4 alkyl; mono- or di-substituted aryl C 1-4 alkyl where the substituents are fluoro, chloro, bromo, iodo, or C 1-10 alkyl, straight or branched chain; R 1 and R 2 are each independent selected from the group consisting of hydrogen, amino, and mono- or di-substituted amino where the substituents are C 1-10 alkyl, straight or branched chain, or C 3-8 cycloalkyl; provided that R 1 and R 2 may not both be amino or substituted amino; and R 3 is hydrogen, trifluoromethyl; fluoro; chloro; bromo; or iodo; or a pharmaceutically acceptable salt thereof.
Claim 2
Independent Claim 167 words
A method for controlling or lowering a patient's serum cholesterol concentration, comprising administering to a patient an effective amount of a compound of the formula (I) ##STR5## wherein Y is O or NH, R is OH, NHCONR 4 R 5 ; or N═C(NR 4 R 5 ) 2 ; where R 4 and R 5 are each independently selected from the group consisting of hydrogen; C 1-10 alkyl, straight or branched chain; aryl C 1-4 alkyl; mono- or di-substituted aryl C 1-4 alkyl where the substituents are fluoro, chloro, bromo, iodo, or C 1-10 alkyl, straight or branched chain; R 1 and R 2 are each independent selected from the group consisting of hydrogen, amino, and mono- or di-substituted amino where the substituents are C 1-10 alkyl, straight or branched chain, or C 3-8 cycloalkyl; provided that R 1 and R 2 may not both be amino or substituted amino; and R 3 is hydrogen, trifluoromethyl; fluoro; chloro; bromo; or iodo; or a pharmaceutically acceptable salt thereof.
Claim 3
Dependent Claim 9 words
The method of claim 1, wherein Y is O.
Claim 4
Dependent Claim 15 words
The method of claim 1, wherein R is N═C(NR 4 R 5 ) 2 .
Claim 5
Dependent Claim 10 words
The method of claim 1, wherein said compound is pyrazinoylguanidine.
Claim 6
Dependent Claim 11 words
The method of claim 1, wherein said compound is 3-amino pyrazinoylguanidine.
Claim 7
Independent Claim 35 words
The method of claims 1-5 wherein the said compound is administered to a patient in an effective amount sufficient to control or lower both a patient's serum cholesterol concentration and the patient's serum triglyceride concentration.

References Cited (Backward Citations)

US4594349A Cited

USPTO Annuity & Maintenance Windows

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3.5 Years (Year 4) 1993-04-23 1993-10-23 1994-04-24 $2000.00 Window Closed / Lapsed
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