US4594349A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Hyperuretic agents
Assignee: Individual
•
Filing: 1982-01-04
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Granted: 1986-06-10
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Expires: 2002-01-04
Abstract
Abstract Hyperuretic agents of the formula: ##STR1## wherein Y is O or NH; R is OH; NHCONR 4 R 5 ; or N═C(NR 4 R 5 ) 2 ; R 1 and R 2 are hydrogen, amino, or mono- or disubstituted amino, provided that R 1 and R 2 may not both be amino or substituted amino; and R 3 is hydrogen or halo; enhance renal excretion of urea, thereby lowering plasma urea concentration, and are therefore useful for treating hypertension, eclampsia, uremia, and similar disorders.
Inventors
- 👤 Karl H. Beyer, Jr.
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-30 17:15
CPC Classifications
C; C07; C07D; C07D241/00; C07D241/02; C07D241/10; C07D241/14; C07D241/24; A; A61; A61K; A61K31/00; A61K31/33; A61K31/395; A61K31/54; A61P; A61P7/00; A61P7/10; A61P9/00; A61P9/12; C07D241/26
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
167 words
A method of treating a hyperuremic condition comprising administering to a host in need of such treatment a therapeutically effective amount of a compound of the formula: ##STR5## wherein Y is O or NH, R is OH; NHCONR 4 R 5 ; or N═C(NR 4 R 5 ) 2 ; where R 4 and R 5 are each independently selected from the group consisting of hyrogen; C 1-10 alkyl, straight or branched chain; aryl C 1-4 alkyl; mono- or disubstituted aryl C 1-4 alkyl where the substituents are fluoro, chloro, bromo, iodo, or C 1-10 alkyl, straight or branched chain; R 1 and R 2 are each independently selected from the group consisting of hydrogen, amino, and mono- or disubstituted amino where the substituents are C 1-10 alkyl, straight or branched chain, or C 3-8 cycloalkyl; provided that R 1 and R 2 may not both be amino or substituted amino; and R 3 is hydrogen; fluoro; chloro; bromo; or iodo; and a pharmaceutically acceptable salt thereof.
Claim 2
Independent Claim
167 words
A method of treating a hyperuremic condition comprising administering to a host in need of such treatment a therapeutically effective amount of a compound of the formula: ##STR5## wherein Y is O or NH, R is OH; NHCONR 4 R 5 ; or N═C(NR 4 R 5 ) 2 ; where R 4 and R 5 are each independently selected from the group consisting of hyrogen; C 1-10 alkyl, straight or branched chain; aryl C 1-4 alkyl; mono- or disubstituted aryl C 1-4 alkyl where the substituents are fluoro, chloro, bromo, iodo, or C 1-10 alkyl, straight or branched chain; R 1 and R 2 are each independently selected from the group consisting of hydrogen, amino, and mono- or disubstituted amino where the substituents are C 1-10 alkyl, straight or branched chain, or C 3-8 cycloalkyl; provided that R 1 and R 2 may not both be amino or substituted amino; and R 3 is hydrogen; fluoro; chloro; bromo; or iodo; and a pharmaceutically acceptable salt thereof.
Claim 3
Dependent Claim
36 words
A method according to claim 1 wherein in Formula I Y is O or NH; one of R 1 and R 2 is hydrogen or amino and the other is hydrogen; and R 3 is hydrogen.
Claim 4
Dependent Claim
14 words
A method according to claim 1 wherein the compound of Formula I is pyrazinoylguanidine.
Claim 5
Dependent Claim
14 words
A method according to claim 1 wherein the comound of Formula I is 3-aminopyrazinoylguanidine.
Claim 6
Dependent Claim
12 words
A method according to claim 1 wherein the hyperuremic condition is uremia.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 1989-06-09 | 1989-12-09 | 1990-06-10 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1993-06-09 | 1993-12-09 | 1994-06-10 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1997-06-09 | 1997-12-09 | 1998-06-10 | $7700.00 | Window Closed / Lapsed |