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US4919924A
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Use of thioredoxin, thioredoxin-derived, or thioredoxin-like dithiol peptides in hair care preparations
Assignee: Repligen Corp
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Filing: 1985-08-28
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Granted: 1990-04-24
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Expires: 2005-08-28
Abstract
Abstract The subject invention enables a more efficient management of hair by providing a novel preparation for waving, straightening, softening, or removing hair, employing as a key ingredient the compound thioredoxin or a thioredoxin-derived, or thioredoxin-like, dithiol peptide in combination with thioglycolic acid compounds. This invention allows hair to be treated at a lower pH to minimize hair damage when waving, straightening, or softening the hair; when used to remove hair, objectionable odors of commercial depilatories are minimized or eliminated.
Inventors
- 👤 Vincent P. Pigiet
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-04 21:51
CPC Classifications
A; A61; A61K; A61K8/00; A61K8/18; A61K8/30; A61K8/64; A61Q; A61Q5/00; A61Q5/04; A61Q9/00; A61Q9/04
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
45 words
A composition of matter for waving, or straightening human hair which comprises a thioglycolic acid compound at a concentration of about 0.01M to about 0.2M, and thioredoxin or a thioredoxin-derived, or thioredoxin-like, dithiol peptide at a concentration of about 1 nmole/ml to about 100 nmole/ml.
Claim 2
Dependent Claim
45 words
A composition of matter for waving, or straightening human hair which comprises a thioglycolic acid compound at a concentration of about 0.01M to about 0.2M, and thioredoxin or a thioredoxin-derived, or thioredoxin-like, dithiol peptide at a concentration of about 1 nmole/ml to about 100 nmole/ml.
Claim 3
Dependent Claim
34 words
A composition of matter for waving human hair, according to claim 1, wherein said thioredoxin-derived dithiol peptide is the fragment containing residues 1 through 37 produced by cyanogen bromide cleavage of E coli thioredoxin.
Claim 4
Dependent Claim
43 words
A composition of matter for waving human hair, according to claim 1, wherein said thioredoxin-derived dithiol peptide is the fragment containing residues 19 through 36 produced by trypsin digestion of residues 1 through 37 produced by cyanogen bromide cleavage of E. coli thioredoxin.
Claim 5
Dependent Claim
51 words
A process for waving, or straightening human hair which comprises applying to said human hair a composition comprising a thioglycolic acid compound at a concentration of about 0.01M to about 0.2M, and thioredoxin or a thioredoxin-derived, or thioredoxin-like, dithiol peptide at a concentration of about 1 nmole/ml to about 100 nmole/ml.
Claim 6
Dependent Claim
51 words
A process for waving, or straightening human hair which comprises applying to said human hair a composition comprising a thioglycolic acid compound at a concentration of about 0.01M to about 0.2M, and thioredoxin or a thioredoxin-derived, or thioredoxin-like, dithiol peptide at a concentration of about 1 nmole/ml to about 100 nmole/ml.
Claim 7
Dependent Claim
34 words
A process for waving human hair, according to claim 4, wherein said thioredoxin-derived, or thioredoxin-like, dithiol peptide is the fragment containing residues 1 through 37 produced by cyanogen bromide cleavage of E. coli thioredoxin.
Claim 8
Dependent Claim
43 words
A process for waving human hair, according to claim 4, wherein said thioredoxin-derived, or thioredoxin-like, dithiol peptide is the fragment containing residues 19 through 36 produced by trypsin digestion of residues 1 through 37 produced by cyanogen bromide cleavage of E. coli thioredoxin.
Claim 9
Dependent Claim
31 words
A process, according to claim 5, wherein said thioredoxin-derived, or thioredoxin-like, dithiol peptide comprises the redox-active peptide sequence Cys-X-Y-Cys-Lys, wherein X and Y, independently, can be any of the amino acids.
Claim 10
Dependent Claim
13 words
A process, according to claim 7, wherein said redox-active peptide sequence is Cys-Gly-Pro-Cys-Lys.
Claim 11
Dependent Claim
51 words
A process for waving, or straightening animal hair which comprises applying to said animal hair a composition comprising a thioglycolic acid compound at a concentration of about 0.01M to about 0.2M, and thioredoxin or a thioredoxin-derived, or thioredoxin-like, dithiol peptide at a concentration of about 1 nmole/ml to about 100 nmole/ml.
Claim 12
Dependent Claim
51 words
A process for waving, or straightening animal hair which comprises applying to said animal hair a composition comprising a thioglycolic acid compound at a concentration of about 0.01M to about 0.2M, and thioredoxin or a thioredoxin-derived, or thioredoxin-like, dithiol peptide at a concentration of about 1 nmole/ml to about 100 nmole/ml.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1993-04-23 | 1993-10-23 | 1994-04-24 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1997-04-23 | 1997-10-23 | 1998-04-24 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2001-04-23 | 2001-10-23 | 2002-04-24 | $7700.00 | Window Closed / Lapsed |