Patent US4918192A successfully refreshed from Google Patents.
US4918192A
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Polysubstituted aryl acridinium esters
Assignee: Bayer Corp
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Filing: 1987-12-14
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Granted: 1990-04-17
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Expires: 2007-12-14
Abstract
Abstract The present invention relates to novel acridinium esters which are useful as luminescent labels in specific binding assays such as immunoassays or nucleic acid hybridization assays. More particularly, polysubstituted aryl acridinium esters are highly stable labels for use in a chemiluminescent immunoassay.
Inventors
- 👤 Say-Jong Law
- 👤 Steve C. S. Chang
- 👤 Stephen A. Palmacci
- 👤 Roger S. Cubicciotti
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 05:33
CPC Classifications
C; C07; C07D; C07D219/00; C07D219/04
Claims Analysis
Total Claims: 3
Claim 1
Independent Claim
148 words
A luminescent compound comprising a polysubstituted aryl acridinium ester selected from the group having the following structure: ##STR5## where R 1 is an alkyl, alkenyl, alkynyl, or aryl group; R 2 , R 3 , R 5 , or R 7 are a hydrogen, amino, carboxyl, hydroxyl, alkoxyl, nitro, or halide group; R 4 or R 8 are an alkyl group; R 6 represents the following substituent: R.sub.6 =-R.sub.9 -R.sub.10 where R 9 is not required but if present is an alkyl, aryl, or aralkyl group, and R 10 is selected from the following: ##STR6## X is CH 3 SO4 - , OSO 2 F - , a halide, OSO 2 CF 3 - , OSO 2 C 4 F 9 - , ##STR7## R is alkyl, aryl, aralkyl; and finally R 5 , R 6 , and R 7 substituent positions on the phenoxy ring are interchangeable.
Claim 2
Dependent Claim
148 words
A luminescent compound comprising a polysubstituted aryl acridinium ester selected from the group having the following structure: ##STR5## where R 1 is an alkyl, alkenyl, alkynyl, or aryl group; R 2 , R 3 , R 5 , or R 7 are a hydrogen, amino, carboxyl, hydroxyl, alkoxyl, nitro, or halide group; R 4 or R 8 are an alkyl group; R 6 represents the following substituent: R.sub.6 =-R.sub.9 -R.sub.10 where R 9 is not required but if present is an alkyl, aryl, or aralkyl group, and R 10 is selected from the following: ##STR6## X is CH 3 SO4 - , OSO 2 F - , a halide, OSO 2 CF 3 - , OSO 2 C 4 F 9 - , ##STR7## R is alkyl, aryl, aralkyl; and finally R 5 , R 6 , and R 7 substituent positions on the phenoxy ring are interchangeable.
Claim 3
Dependent Claim
62 words
A luminescent compound according to claim 1 wherein R 1 is a methyl group; R 2 , R 3 , R 5 , and R 7 are hydrogen; R 4 and R 8 are a methyl group; R 10 is an N-succinimidyl oxycarbonyl group attached directly to the para-position of the phenoxy ring; and X is CH 3 SO 4 - .
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1993-04-16 | 1993-10-16 | 1994-04-17 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1997-04-16 | 1997-10-16 | 1998-04-17 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2001-04-16 | 2001-10-16 | 2002-04-17 | $7700.00 | Window Closed / Lapsed |