US4918165A
Expired / Lapsed
US
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Mitotic inhibitor and method for preventing posterior lens capsule opacification after extracapsular extraction
Assignee: BIOTECHNOLOGY LLC
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Filing: 1987-07-16
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Granted: 1990-04-17
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Expires: 2007-07-16
Abstract
Abstract A conjugated cytotoxin is provided for preventing posterior lens capsule opacification (after-cataract) after extracapsular extraction. Preferably, the mitotic inhibitor of lens epithelial cells comprises a conjugate containing methotrexate which is covalently linked to an antibody, such as anticollagen, in approximately a molar ratio of 1:1 to 10:1. The mitotic conjugate may be instilled in the anterior or posterior chamber of the eye, preferably immediately after the lens has been removed, or coated onto an intraocular lens prior to insertion onto the posterior lens capsule. Similar conjugates may be attached to other artificial materials in the body to fight fibroblast proliferation.
Inventors
- 👤 David B. Soll
- 👤 Thomsen J. Hansen
- 👤 Ihab Kamel
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-29 20:23
CPC Classifications
A; A61; A61F; A61F2/00; A61F2/02; A61F2/14; A61F2/16; A61F2/0077; A61F2/1613; A61K; A61K47/00; A61K47/50; A61K47/51; A61K47/68; A61K47/6801; A61K47/6803; A61L; A61L27/00; A61L27/50; A61L27/54; A61P; A61P27/00; A61P27/02; A61P27/12; A61P35/00; A61P43/00; A61F2/1602; A61F2/1605; A61F2/161; A61F2002/009; A61L2300/00; A61L2300/20; A61L2300/252; A61L2300/256; A61L2300/40; A61L2300/432; A61L2300/45
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
43 words
A mitotic inhibitor for the prevention of posterior lens capsule opacification when instilled into the anterior or posterior chamber of the eye during or after extracapsular extraction comprising: a conjugate of an anticollagen antibody and a cytotoxin to lens epithelial cells and fibroblasts.
Claim 2
Dependent Claim
43 words
A mitotic inhibitor for the prevention of posterior lens capsule opacification when instilled into the anterior or posterior chamber of the eye during or after extracapsular extraction comprising: a conjugate of an anticollagen antibody and a cytotoxin to lens epithelial cells and fibroblasts.
Claim 3
Dependent Claim
15 words
A mitotic inhibitor according to claim 1 wherein said antibody and cytotoxin are covalently linked.
Claim 4
Dependent Claim
12 words
A mitotic inhibitor according to claim 1, wherein said cytotoxin comprises methotrexate.
Claim 5
Dependent Claim
15 words
A mitotic inhibitor according to claim 1, wherein said antibody is specific to lens capsule.
Claim 6
Dependent Claim
15 words
A mitotic inhibitor according to claim 1, wherein said antibody is specific to lens cells.
Claim 7
Dependent Claim
23 words
A mitotic inhibitor according to claim 1, wherein said conjugate comprises methotrexate and anticollagen in a molar ratio of about 1:1 to 10:1.
Claim 8
Dependent Claim
35 words
A method of preventing posterior lens capsule opacification after extracapsular cataract extraction comprising: instilling into the anterior or posterior chamber of the eye during or after the extracapsular extraction the mitotic inhibitor of claim 1.
Claim 9
Dependent Claim
25 words
A method of preventing posterior lens capsule opacification after extracapsular cataract extraction comprising: instilling the mitotic inhibitor of claim 1 immediately following the cataract extraction.
Claim 10
Dependent Claim
24 words
A method of preventing posterior lens capsule opacification after extracapsular cataract extraction comprising: coating of intraocular lenses with the mitotic inhibitor of claim 1.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1993-04-16 | 1993-10-16 | 1994-04-17 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1997-04-16 | 1997-10-16 | 1998-04-17 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2001-04-16 | 2001-10-16 | 2002-04-17 | $7700.00 | Window Closed / Lapsed |