US4515794A
Expired / Lapsed
US
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Mitotic inhibitors preventing posterior lens capsule opacification
Assignee: Baylor College of Medicine
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Filing: 1983-07-20
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Granted: 1985-05-07
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Expires: 2003-07-20
Abstract
Abstract Disclosed are mitotic inhibitors effective for and methods of preventing posterior lens capsule opacification after extracapsular extraction. The mitotic inhibitors comprise osmotically balanced solutions containing either methotrexate or retinoic acid, or both, in at least the minimal effective dosage at the end of one lens epithelial cell cycle. The mitotic inhibitors are instilled in the anterior chamber of the eye preferably immediately after the lens has been removed.
Inventors
- 👤 Jared M. Emery
- 👤 Raymond Y. Chan
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 07:02
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/185; A61K31/19; A61K31/20; A61K31/33; A61K31/395; A61K31/495; A61K31/505
Claims Analysis
Total Claims: 4
Claim 1
Independent Claim
40 words
A mitotic inhibitor effective to prevent posterior lens capsule opacification when instilled into the anterior chamber of the eye after extracapsular extraction comprising, an osmotically balanced solution containing a minimum concentration of 0.0454 mg of methotrexate per cc of solution.
Claim 2
Dependent Claim
40 words
A mitotic inhibitor effective to prevent posterior lens capsule opacification when instilled into the anterior chamber of the eye after extracapsular extraction comprising, an osmotically balanced solution containing a minimum concentration of 0.0454 mg of methotrexate per cc of solution.
Claim 3
Dependent Claim
31 words
A method of preventing posterior lens capsule opacification after extracapsular cataract extraction comprising, instilling into the anterior chamber of the eye after the extracapsular extraction the mitotic inhibitor of claim 1.
Claim 4
Dependent Claim
25 words
A method of preventing posterior lens capsule opacification after extracapsular cataract extraction comprising, instilling the mitotic inhibitor of claim 1 immediately following the cataract extraction.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1988-05-06 | 1988-11-05 | 1989-05-07 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1992-05-06 | 1992-11-05 | 1993-05-07 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1996-05-06 | 1996-11-05 | 1997-05-07 | $7700.00 | Window Closed / Lapsed |