US4917930A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Perfluoro compound dispersions containing reduced amounts of surfactant and process of preparation
Assignee: Ibah Inc
•
Filing: 1986-10-03
•
Granted: 1990-04-17
•
Expires: 2006-10-03
Abstract
Abstract Compositions having enhanced gas and drug transporting capability, are prepared by providing a perfluoro compound dispersed in an aqueous medium with a surfactant to form an aqueous initial dispersion, concentrating the perfluoro compound phase of the dispersion as by centrifugation or filtration, wherein a portion of the surfactant remains complexed with the particles of the perfluoro compound phase and the balance of the surfactant is in the aqueous phase, separating the phases, and redispersing the particles of the concentrated perfluoro compound phase to form a final dispersion in which greater than 65% by weight, and preferably at least 75%, of the surfactant present is complexed with the perfluoro compound particles.
Inventors
- 👤 William McCormick
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-04 19:36
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/0012; A61K9/0019; A61K9/0026
Claims Analysis
Total Claims: 22
Claim 1
Independent Claim
39 words
A composition comprising a stable, uniform, aqueous dispersion of a perfluoro compound having gas transfer properties and a surfactant, wherein greater than about 75% by weight of the surfactant present in said dispersion is complexed with the perfluoro compound.
Claim 2
Dependent Claim
39 words
A composition comprising a stable, uniform, aqueous dispersion of a perfluoro compound having gas transfer properties and a surfactant, wherein greater than about 75% by weight of the surfactant present in said dispersion is complexed with the perfluoro compound.
Claim 3
Dependent Claim
21 words
The composition of claim 1 wherein at least 85-90% by weight of the surfactant present is complexed with the perfluoro compound.
Claim 4
Dependent Claim
41 words
The composition of claim 1 wherein the perfluoro compound is a non-aromatizable perfluorinated C 9 -C 18 polycyclic hydrocarbon containing at least two bridgehead carbon atoms linked through a bridge containing at least one carbon atom, and the surfactant is nonionic.
Claim 5
Dependent Claim
15 words
The composition of claim 3 wherein the composition comprises a mixture of F-dimethyladamantane and F-trimethylbicyclo[3.3.1]nonane.
Claim 6
Dependent Claim
16 words
The composition of claim 1 or 3 wherein the surfactant is a fluorinated amidoamine oxide compound.
Claim 7
Dependent Claim
25 words
The composition of claim 1 or 3 wherein the surfactant is an oxyethylene or oxypropylene homopolymer, or block copolymer of ethylene oxide and propylene oxide.
Claim 8
Dependent Claim
23 words
The composition of claim 1 or 3 wherein the surfactant is a phospholipid selected from the group consisting of lecithin and yolk phospholipid.
Claim 9
Dependent Claim
11 words
The composition of claim 1 wherein the dispersion contains additional surfactant.
Claim 10
Dependent Claim
90 words
A process for preparing an aqueous dispersion of a perfluoro compound having gas transfer properties, which comprises: (a) providing an initial dispersion comprising (i) a perfluoro compound phase containing a surfactant complexed with the perfluoro compound, and (ii) an aqueous phase containing uncomplexed surfactant; (b) concentrating the perfluoro compound phase; (c) recovering the concentrated perfluoro compound phase from the aqueous phase; and (d) redispersing the concentrated perfluoro compound phase with an amount of an aqueous medium effective to redisperse the perfluoro compound phase and thereby to form a final dispersion.
Claim 11
Dependent Claim
90 words
A process for preparing an aqueous dispersion of a perfluoro compound having gas transfer properties, which comprises: (a) providing an initial dispersion comprising (i) a perfluoro compound phase containing a surfactant complexed with the perfluoro compound, and (ii) an aqueous phase containing uncomplexed surfactant; (b) concentrating the perfluoro compound phase; (c) recovering the concentrated perfluoro compound phase from the aqueous phase; and (d) redispersing the concentrated perfluoro compound phase with an amount of an aqueous medium effective to redisperse the perfluoro compound phase and thereby to form a final dispersion.
Claim 12
Dependent Claim
26 words
The process of claim 9 wherein additional surfactant is added in step (d) in an amount effective to promote redispersion of the concentrated perfluoro compound phase.
Claim 13
Dependent Claim
25 words
Process of claim 9 wherein greater than about 65% by weight of the surfactant present in the final dispersion is complexed with the perfluoro compound.
Claim 14
Dependent Claim
15 words
The process of claim 9 wherein the concentrating of step (b) is effected by centrifugation.
Claim 15
Dependent Claim
25 words
The process of claim 9 wherein the initial dispersion is prepared by agitating a mixture of perfluoro compound and a surfactant in an aqueous medium.
Claim 16
Dependent Claim
49 words
The process of claim 9 wherein particles having a desired average particle size of from about 0.05 to 0.6 micron are recovered from the perfluoro compound phase recovered in step (c) and redispersed in step (d), and the remaining undesired particles falling outside said desired range are thereafter recovered.
Claim 17
Dependent Claim
56 words
The process of claim 9 wherein particles having a desired average particle size from about 0.05 to 0.6 micron are recovered from the perfluoro compound phase recovered in step (c) and redispersed in step (d), the remaining undesired particles falling outside said desired range are thereafter recovered and recycled to the initial dispersion of step (a).
Claim 18
Dependent Claim
41 words
The process of claim 9 wherein the perfluoro compound is a non-aromatizable perfluorinated C 9 -C 18 polycyclic hydrocarbon containing at least two bridgehead carbon atoms linked through a bridge containing at least one carbon atom, and the surfactant is nonionic.
Claim 19
Dependent Claim
16 words
The process of claim 16 wherein the perfluoro compound comprises a mixture of F-dimethyladamantine and F-trimethylbicyclo[3.3.1]nonane.
Claim 20
Dependent Claim
25 words
The process of claim 9 wherein at least 75% by weight of the surfactant present in the final dispersion is complexed with the perfluoro compound.
Claim 21
Dependent Claim
25 words
The process of claim 9 wherein at least 85-90% by weight of the surfactant present in the final dispersion is complexed with the perfluoro compound.
Claim 22
Dependent Claim
14 words
The aqueous dispersion produced by the process of claims 9, 11, 16 or 17.
References Cited (Backward Citations)
US3547995A
Cited
US3828085A
Cited
US3778381A
Cited
US3911138A
Cited
US3911138B1
Cited
US3993581A
Cited
US4105798A
Cited
US4461717A
Cited
US4443480A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1993-04-16 | 1993-10-16 | 1994-04-17 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1997-04-16 | 1997-10-16 | 1998-04-17 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2001-04-16 | 2001-10-16 | 2002-04-17 | $7700.00 | Window Closed / Lapsed |