Encapsulated topical delivery system

Claim 2

A delivery system for the immediate and sustained topical application of at least one topically-active agent to a localized area of the body comprising a viscous carrier containing a dissolved or dispersed topically-active agent and a topically-active agent microencapsulated within a semipermeable anistropic salt film which is the emulsion reaction product of a) a partially lipophilic, partially hydrophilic, polyfunctional Lewis acid or salt thereof in aqueous medium with b) a Lewis base or salt thereof in a water-immiscible, slightly polar organic solvent for the base.

Claim 3

The delivery system of claim 1, wherein the viscous carrier is a thermogel.

Claim 4

The delivery system of claim 2, wherein the thermogel contains at least two different topically-active agents.

Claim 5

The delivery system of claim 1 wherein the localized area of the body is the oral cavity.

Claim 6

The delivery system of claim 4, wherein the localized area of the body is the periodontal region.

Claim 7

The delivery system of claim 1, wherein the topically-active agent is a pharmaceutical, cosmetic, or anaesthetic.

Claim 8

The delivery system of claim 5, wherein at least one of the topically-active agents is an antibiotic.

Claim 9

The delivery system of claim 2, wherein said Lewis acid or salt thereof is acacia gum, arabic acid, carboxymethylcellulose, methylcellulose, oxidized cellulose, pectin, tragacanth, ghatti gum, guar gum, polyethylene glycol, agar, sodium carboxymethylcellulose, or an alkali metal salt of polyacrylic acid or polyoxyethylene cross-linked with polyacrylic acid.

Claim 10

The delivery system of claim 8, wherein said Lewis base or salt thereof is hexylamine, isopentylamine, n-methylpiperidine, piperidine, dimethylenediamine, hexanediamine, piperazine, triethylenediamine, ethylenediamine, hexamethylrosanilium cation, rosanilium cation, tetramethylrosanilium cation, melamine, tetraethylpentamine, triethyltetramine, benzalkonium chloride, or cetylpyridinium chloride.

Claim 11

The delivery system of claim 2, wherein the thermogel is a poloxamer, poloxamine, or methylcellulose.

Claim 12

A method for preparing the delivery system of claim 1, comprising (a) mixing together (i) a partially hydrophilic, partially lipophilic, polyfunctional Lewis acid or salt thereof in an aqueous medium, (ii) a water-immiscible solution of a Lewis base or salt thereof in a slightly polar solvent for the Lewis base, and (iii) a first topically-active agent, with agitation to form an aqueous suspension of microcapsules encapsulating and semipermeable to the first topically-active agent; (b) recovering a concentrate of the microcapsules from the aqueous suspension thereof; (c) forming an aqueous thermogel solution; and (d) combining the microcapsule concentrate, the thermogel solution, and a second topically-active agent to form said delivery system.

Claim 13

The method of claim 11, wherein the first topically-active agent is first combined with the water-immiscible solution of Lewis base or salt thereof before admixing with the Lewis acid or salt thereof in aqueous medium.

Claim 14

The method of claim 11, wherein the microcapsule concentrate is resuspended in an aqueous solution or dispersion of the second topically-active agent before combining with the thermogel solution.

Claim 15

The method of claim 11, wherein the second topically-active agent is admixed with the thermogel solution before combining with the microcapsule concentrate.

Claim 16

The method of claim 11, wherein the first and second topically-active agents are different.

Claim 17

The method of claim 11 wherein the thermogel is a poloxamer, poloxamine, or methylcellulose.

Claim 18

The method of claim 11, wherein the Lewis acid or salt thereof is acacia gum, arabic acid, carboxymethylcellulose, methylcellulose, oxidized cellulose, pectin, tragacanth, ghatti gum, guar gum, polyethylene glycol, agar, sodium carboxymethylcellulose, or an alkali metal salt of polyacrylic acid or polyoxyethylene cross-linked with polyacrylic acid.

Claim 19

The method of claim 11, wherein the Lewis base or salt thereof is hexylamine, isopentylamine, n-methylpiperidine, piperidine, dimethylenediamine, hexanediamine, piperazine, triethylenediamine, ethylenediamine, hexamethylrosanilium cation, rosanilium cation, tetramethyrosanilium cation, melamine, tetraethylpentamine, triethyltetramine, benzalkonium chloride, or cetylpyridinium chloride.

Claim 20

The method of claim 11, wherein either the first or second topically-active agent, or both, is an antibiotic.

Claim 21

The method of claim 11, wherein the first and second topically-active agents are pharmaceuticals, cosmetics, or anaesthetics.