Patent US4911713A successfully refreshed from Google Patents.
US4911713A
Expired / Lapsed
US
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Method of making vascular prosthesis by perfusion
Assignee: Individual
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Filing: 1987-01-27
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Granted: 1990-03-27
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Expires: 2007-01-27
Abstract
Abstract A method of making an impermeable vascular prosthesis is disclosed which comprises the steps of treating a porous textile conduit with a first solution of cross-linking agent; perfusing the conduit with a second solution of cross-linking agent and protein; and drying the perfused conduit to allow gelation in a second solution to form an impermeable vascular prosthesis. Perfusion of the lumen of the prosthesis is performed with sufficient pressure to ensure that all interstices of the porous textile conduit are completely filled. A gelation mixture comprising albumin and glutaraldehyde is preferably utilized for perfusion of the prosthesis. Methods for preserving these grafts indefinitely by treatment with glycerol and other alkyl alcohols are also disclosed.
Inventors
- 👤 Lester R. Sauvage
- 👤 Svetlana Kaplan
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 16:27
CPC Classifications
A; A61; A61F; A61F2/00; A61F2/02; A61F2/04; A61F2/06; A61F2/062; A61L; A61L27/00; A61L27/14; A61L27/22; A61L27/28; A61L27/34; Y; Y10; Y10S; Y10S623/00; Y10S623/901; Y10S623/92; Y10S623/921
Claims Analysis
Total Claims: 41
Claim 1
Independent Claim
106 words
A method of making an impermeable vascular prosthesis comprising the steps of: perfusing the interior of a textile conduit at a pressure and under conditions sufficient to fill substantially all of the interstices of said conduit with a first solution of cross-linking agent and protein; perfusing the exterior of the conduit with a second solution of cross-linking agent and protein; controlling the pressure and pressure differential between the first and second solutions to control the direction and rate of flow of said solutions through the interstices of said conduit; and drying said perfused conduit to allow gelation of the solution to form an impermeable vascular prosthesis.
Claim 2
Independent Claim
106 words
A method of making an impermeable vascular prosthesis comprising the steps of: perfusing the interior of a textile conduit at a pressure and under conditions sufficient to fill substantially all of the interstices of said conduit with a first solution of cross-linking agent and protein; perfusing the exterior of the conduit with a second solution of cross-linking agent and protein; controlling the pressure and pressure differential between the first and second solutions to control the direction and rate of flow of said solutions through the interstices of said conduit; and drying said perfused conduit to allow gelation of the solution to form an impermeable vascular prosthesis.
Claim 3
Dependent Claim
23 words
The method of claim 1 wherein the second solution is perfused simultaneously with the first solution or is perfused after a predetermined interval.
Claim 4
Dependent Claim
16 words
The method of claim 1 wherein the compositions of the first and second solutions are identical.
Claim 5
Dependent Claim
16 words
The method of claim 1 wherein the cross-linking agent is characterized as having an aldehyde moiety.
Claim 6
Dependent Claim
22 words
The method of claim 1 wherein the cross-linking agent is selected from the group consisting of glutaraldehyde, formaldehyde, acrolein and dialdehyde starches.
Claim 7
Dependent Claim
14 words
The method of claim 1 wherein the cross-linking agent is a solution of glutaraldehyde.
Claim 8
Dependent Claim
20 words
The method of claim 1 wherein the cross-linking agent is a solution of glutaraldehyde ranging in concentration from 0.3%-25% (v/v).
Claim 9
Dependent Claim
19 words
The method of claim 1 wherein the protein is selected from the group consisting of albumin, collagen, and fibrinogen.
Claim 10
Dependent Claim
33 words
The method of claim 1 wherein the solution of cross-linking agent and protein comprises: glutaraldehyde having a final concentration ranging from 0.4%-1.0% (v/v); and albumin having a final concentration ranging from 6%-15% (w/v).
Claim 11
Dependent Claim
11 words
The method of claim 1 wherein the textile conduit is polyester.
Claim 12
Dependent Claim
12 words
The method of claim 10 wherein the textile conduit is polyethylene terephthalate.
Claim 13
Dependent Claim
20 words
The method of claim 1 wherein the step of drying the prosthesis comprises rotating the prosthesis about its longitudinal axis.
Claim 14
Independent Claim
118 words
A method of making an impermeable vascular prosthesis comprising the steps of: perfusing the interior of a textile conduit with a first solution of cross-linking agent and protein; perfusing the exterior of the conduit with a second solution of cross-linking agent and protein; controlling the pressure and pressure differential between the first and second solutions to control the direction and rate of flow of said solutions through the interstices of said conduit; drying said perfused conduit; re-perfusing the interior of the conduit at a pressure sufficient to fill substantially all of the interstices of said conduit and under conditions sufficient to control the kinetics of gel formation; and re-drying said re-perfused conduit to form an impermeable vascular prosthesis.
Claim 15
Independent Claim
118 words
A method of making an impermeable vascular prosthesis comprising the steps of: perfusing the interior of a textile conduit with a first solution of cross-linking agent and protein; perfusing the exterior of the conduit with a second solution of cross-linking agent and protein; controlling the pressure and pressure differential between the first and second solutions to control the direction and rate of flow of said solutions through the interstices of said conduit; drying said perfused conduit; re-perfusing the interior of the conduit at a pressure sufficient to fill substantially all of the interstices of said conduit and under conditions sufficient to control the kinetics of gel formation; and re-drying said re-perfused conduit to form an impermeable vascular prosthesis.
Claim 16
Dependent Claim
23 words
The method of claim 13 wherein the second solution is perfused simultaneously with the first solution or is perfused after a predetermined interval.
Claim 17
Dependent Claim
16 words
The method of claim 13 wherein the compositions of the first and second solutions are identical.
Claim 18
Dependent Claim
16 words
The method of claim 13 wherein the cross-linking agent is characterized as having an aldehyde moiety.
Claim 19
Dependent Claim
22 words
The method of claim 13 wherein the cross-linking agent is selected from the group consisting of glutaraldehyde, formaldehyde, acrolein, and dialdehyde starches.
Claim 20
Dependent Claim
14 words
The method of claim 13 wherein the cross-linking agent is a solution of glutaraldehyde.
Claim 21
Dependent Claim
20 words
The method of claim 13 wherein the cross-linking agent is a solution of glutaraldehyde ranging in concentration from 0.3%-25% (v/v).
Claim 22
Dependent Claim
19 words
The method of claim 13 wherein the protein is selected from the group consisting of albumin, collagen, and fibrinogen.
Claim 23
Dependent Claim
33 words
The method of claim 13 wherein the solution of cross-linking agent and protein comprises: glutaraldehyde having a final concentration ranging from 0.4%-1.0% (v/v); and albumin having a final concentration ranging from 6%-15% (w/v).
Claim 24
Dependent Claim
11 words
The method of claim 13 wherein the textile conduit is polyester.
Claim 25
Dependent Claim
12 words
The method of claim 13 wherein the textile conduit is polyethylene terephthalate.
Claim 26
Dependent Claim
22 words
The method of claim 13 wherein the steps of drying and re-drying the prosthesis comprises rotating the prosthesis about its longitudinal axis.
Claim 27
Independent Claim
100 words
A method of making an impermeable vascular prosthesis comprising the steps of: treating a porous textile conduit with a first solution of a cross-linking agent; perfusing said conduit with a second solution of cross-linking agent and protein; perfusing the exterior of the conduit with a third solution of cross-linking agent and protein; controlling the pressure and pressure differential between the second and third solutions to control the direction and rate of flow of said solutions through the interstices of said conduit; and drying said perfused conduit to allow complete gelation of the second solution to form an impermeable vascular prosthesis.
Claim 28
Independent Claim
100 words
A method of making an impermeable vascular prosthesis comprising the steps of: treating a porous textile conduit with a first solution of a cross-linking agent; perfusing said conduit with a second solution of cross-linking agent and protein; perfusing the exterior of the conduit with a third solution of cross-linking agent and protein; controlling the pressure and pressure differential between the second and third solutions to control the direction and rate of flow of said solutions through the interstices of said conduit; and drying said perfused conduit to allow complete gelation of the second solution to form an impermeable vascular prosthesis.
Claim 29
Dependent Claim
44 words
The method of claim 25 wherein the step of treating the porous textile conduit comprises the step of perfusing the interior of the conduit with the second solution with sufficient pressure to ensure that all interstices of the porous textile conduit are completely filled.
Claim 30
Dependent Claim
23 words
The method of claim 25 wherein the third solution is perfused simultaneously with the second solution or is perfused after a predetermined interval.
Claim 31
Dependent Claim
16 words
The method of claim 25 wherein the compositions of the second and third solutions are identical.
Claim 32
Dependent Claim
16 words
The method of claim 25 wherein the cross-linking agent is characterized as having an aldehyde moiety.
Claim 33
Dependent Claim
22 words
The method of claim 25 wherein the cross-linking agent is selected from the group consisting of glutaraldehyde, formaldehyde, acrolein, and dialdehyde starches.
Claim 34
Dependent Claim
14 words
The method of claim 25 wherein the cross-linking agent is a solution of glutaraldehyde.
Claim 35
Dependent Claim
20 words
The method of claim 25 wherein the cross-linking agent is a solution of glutaraldehyde ranging in concentration from 0.3%-25% (v/v).
Claim 36
Dependent Claim
19 words
The method of claim 25 wherein the protein is selected from the group consisting of albumin, collagen and fibrinogen.
Claim 37
Dependent Claim
34 words
The method of claim 25 wherein the second solution of cross-linking agent and protein comprises: glutaraldehyde having a final concentration ranging from 0.4%-1.0% (v/v); and albumin having a final concentration ranging from 6%-15% (w/v).
Claim 38
Dependent Claim
13 words
The method of claim 25 wherein the textile conduit is knit or woven.
Claim 39
Dependent Claim
11 words
The method of claim 35 wherein the textile conduit is polyester.
Claim 40
Dependent Claim
12 words
The method of claim 36 wherein the textile conduit is polyethylene terephthalate.
Claim 41
Dependent Claim
20 words
The method of claim 25 wherein the step of drying the prosthesis comprises rotating the prosthesis about its longitudinal axis.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1993-03-26 | 1993-09-25 | 1994-03-27 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1997-03-26 | 1997-09-25 | 1998-03-27 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2001-03-26 | 2001-09-25 | 2002-03-27 | $7700.00 | Window Closed / Lapsed |