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US4909257A
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Method for attaining in vivo tissue-specific contrast by nuclear magnetic resonance imaging
Assignee: University of California, San Diego
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Filing: 1989-04-28
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Granted: 1990-03-20
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Expires: 2009-04-28
Abstract
Abstract A method is provided for obtaining in vivo diferentiation of tissues in an animal by nuclear magnetic resonance imaging comprising the steps of introducing into the animal a complex comprising a paramagnetic ferric ion and a chelator. Particular contrast agents, Fe(HBED) and Fe(EHPG), are excretable by a hepatobiliary pathway.
Inventors
- 👤 Barry L. Engelstad
- 👤 Robert C. Brasch
- 👤 Robert S. Hattner
- 👤 George Wesbey
- 👤 John P. Huberty
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-04 06:20
CPC Classifications
A; A61; A61K; A61K49/00; A61K49/06; A61K49/08; A61K49/10; A61K49/101; A61K49/103; Y; Y10; Y10T; Y10T436/00; Y10T436/24
Claims Analysis
Total Claims: 5
Claim 1
Independent Claim
72 words
A method of obtaining in vivo differentiation of tissues in the hepatobiliary system of an animal by nuclear magnetic resonance imaging comprising the steps of introducing into said tissues a metal complex of paramanetic iron and a chelator, said complex being excretable through said hepatobiliary system of said animal; and observing a nuclear magnetic image of said tissues, wherein said chelator is selected from the group consisting of N,N'-bis(2-hydroxybenzyl)ethylendiamine-N,N'-diacetic acid and ethylenebis-N,N'-(o-hydroxyphenylglycine).
Claim 2
Independent Claim
72 words
A method of obtaining in vivo differentiation of tissues in the hepatobiliary system of an animal by nuclear magnetic resonance imaging comprising the steps of introducing into said tissues a metal complex of paramanetic iron and a chelator, said complex being excretable through said hepatobiliary system of said animal; and observing a nuclear magnetic image of said tissues, wherein said chelator is selected from the group consisting of N,N'-bis(2-hydroxybenzyl)ethylendiamine-N,N'-diacetic acid and ethylenebis-N,N'-(o-hydroxyphenylglycine).
Claim 3
Dependent Claim
13 words
A method according to claim 1 wherein said chelator comprises N,N'-bis(2-hydroxybenzyl) ethylenediamine-N,N'-diacetic acid.
Claim 4
Dependent Claim
11 words
A method according to claim 1 wherein said chelator comprises ethylenebis-N,N'-(o-hydroxyphenylglycine).
Claim 5
Dependent Claim
14 words
A method according to claim 1 wherein said complex is conjugated with a biomolecule.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1993-03-19 | 1993-09-18 | 1994-03-20 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1997-03-19 | 1997-09-18 | 1998-03-20 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2001-03-19 | 2001-09-18 | 2002-03-20 | $7700.00 | Window Closed / Lapsed |