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US4908405A
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US
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Graft copolymers of crosslinked polymers and polyoxyethylene, processes for their production, and their usage
Assignee: Individual
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Filing: 1986-01-02
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Granted: 1990-03-13
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Expires: 2006-01-02
Abstract
Abstract The invention relates to graft copolymers of crosslinked polymers and linear polyoxyethylene, processes for their production, and their use as a substrate for peptide or nucleotide synthesis or for the covalent fixation of peptides, active protein compounds, and enzymes for affinity chromotography, diagnostic agents, and biotechnological methods.
Inventors
- 👤 Ernst Bayer
- 👤 Wolfgang Rapp
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 03:40
CPC Classifications
C; C08; C08F; C08F8/00
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
96 words
A graft copolymer comprising a polymer having a degree of crosslinking of 0.05 to 10%, selected from the group consisting of a polyvinyl alcohol, a polyhydroxystyrene, a polymer produced from chloromethylated polystyrene and ethylene glycol, a polymer produced from chloromethylated polystyrene and oligoethylene glycols, a polyacrylate functionalized by hydroxy groups, and a polymethacrylate functionalized by hydroxy groups which contains polyoxyethylene chains which have an average molecular weight of 500 to 40,000; said copolymer containing 0.02 to 15 meq free hydroxy groups per gram of copolymer, and being obtained by reacting the crosslinked polymer with ethylene oxide.
Claim 2
Dependent Claim
96 words
A graft copolymer comprising a polymer having a degree of crosslinking of 0.05 to 10%, selected from the group consisting of a polyvinyl alcohol, a polyhydroxystyrene, a polymer produced from chloromethylated polystyrene and ethylene glycol, a polymer produced from chloromethylated polystyrene and oligoethylene glycols, a polyacrylate functionalized by hydroxy groups, and a polymethacrylate functionalized by hydroxy groups which contains polyoxyethylene chains which have an average molecular weight of 500 to 40,000; said copolymer containing 0.02 to 15 meq free hydroxy groups per gram of copolymer, and being obtained by reacting the crosslinked polymer with ethylene oxide.
Claim 3
Dependent Claim
15 words
The graft copolymer of claim 1 wherein the amount of hydroxy groups is 0.05-10 meq/g.
Claim 4
Dependent Claim
22 words
The graft copolymer of claim 1 wherein the crosslinked polymer is crosslinked polystyrenes containing hydroxy groups in the amount of 0.05-0.7 meq/g.
Claim 5
Dependent Claim
22 words
The graft copolymer of claim 1 wherein the crosslinked polymer is polyvinyl alcohol containing hydroxy groups in the amount of 1-10 meq/g.
Claim 6
Dependent Claim
17 words
The graft copolymer of claim 1 wherein the average molecular weight of the polyoxyethylene chains is 800-10,000.
Claim 7
Dependent Claim
19 words
The graft copolymer of claim 1 wherein the average molecular weight of the polyoxyethylene chains is 2,000 to 3,000.
Claim 8
Dependent Claim
18 words
The graft copolymer of claim 1 wherein the extent of crosslinking of the copolymer is 1 to 2%.
Claim 9
Dependent Claim
15 words
The graft copolymer of claim 1 wherein the crosslinked polymer is polystyrene crosslinked with divinylbenzene.
Claim 10
Dependent Claim
18 words
The graft copolymer of claim 1 wherein the crosslinked polymer is produced from chloromethylated polystyrene and tetraethylene glycol.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1993-03-12 | 1993-09-11 | 1994-03-13 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1997-03-12 | 1997-09-11 | 1998-03-13 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2001-03-12 | 2001-09-11 | 2002-03-13 | $7700.00 | Window Closed / Lapsed |