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US4905707A
Expired / Lapsed
US
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Method for recognizing rejection of transplanted hearts
Assignee: Siemens AG
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Filing: 1986-12-08
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Granted: 1990-03-06
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Expires: 2006-12-08
Abstract
Abstract A method is disclosed for monitoring the body reaction against a heart transplant. When a heart is newly transplanted, electrocardiac signals from the transplanted heart are detected. The analog signals are converted to digital signals. A first differentiation of the digital signals is carried out over a continuous time period to create reference differentiated signals. At a later time during monitoring of the transplanted heart, analog electrocardiac signals are again detected from the transplanted heart. These analog signals are converted to digital signals. A first differentiation is carried out of these digital signals over a continuous time period to create monitored differentiated signals. The reference differentiated signals and the monitored differentiated signals are compared at least with respect to amplitude to create comparison results. All of the above operations occur within the body. These comparison results are recorded and stored for use in determining body rejection of the transplanted heart.
Inventors
- 👤 David W. Davies
- 👤 Bengt A. Lekholm
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-28 21:40
CPC Classifications
A; A61; A61B; A61B5/00; A61B5/41; A61B5/413; A61B5/0002; A61B5/0004; A61B5/0006; A61B5/24; A61B5/316; A61B5/318; A61B5/346; A61B5/349; A61B5/72; A61B5/7235; A61B5/7239
Claims Analysis
Total Claims: 14
Claim 1
Independent Claim
171 words
A method of monitoring a body reaction against a heart transplanted therein, comprising steps of: detecting inside the body analog electrocardiac signals from a newly transplanted heart in the body; within the body converting the analog signals to digital signals; within the body carrying out a first differentiation of the digital signals over a continuous time period to create reference differentiated signals; at a later time during monitoring of the heart, again detecting within the body analog electrocardiac signals from the transplanted heart; within the body converting the analog signals to digital signals; within the body carrying out a first differentiation of the digital signals over a continuous time period to create newly monitored differentiated signals; within the body comparing the newly monitored differentiated signals with the reference differentiated signals to create comparison results; recording and storing within the body the comparison results; and at a desired time, transmitting the stored comparison results from inside the body to outside the body for use in analyzing body rejection of the transplanted heart.
Claim 2
Independent Claim
171 words
A method of monitoring a body reaction against a heart transplanted therein, comprising steps of: detecting inside the body analog electrocardiac signals from a newly transplanted heart in the body; within the body converting the analog signals to digital signals; within the body carrying out a first differentiation of the digital signals over a continuous time period to create reference differentiated signals; at a later time during monitoring of the heart, again detecting within the body analog electrocardiac signals from the transplanted heart; within the body converting the analog signals to digital signals; within the body carrying out a first differentiation of the digital signals over a continuous time period to create newly monitored differentiated signals; within the body comparing the newly monitored differentiated signals with the reference differentiated signals to create comparison results; recording and storing within the body the comparison results; and at a desired time, transmitting the stored comparison results from inside the body to outside the body for use in analyzing body rejection of the transplanted heart.
Claim 3
Dependent Claim
18 words
A method according to claim 1 wherein amplitudes of the reference and newly monitored differentiated signals are compared.
Claim 4
Dependent Claim
19 words
A method according to claim 1 wherein intervals of the reference and newly monitored differentiated signals are also compared.
Claim 5
Dependent Claim
18 words
A method according to claim 1 wherein polarities of the reference and newly monitored differentiated signals are compared.
Claim 6
Dependent Claim
21 words
A method according to claim 1 wherein an amplitude sequence of said reference and newly monitored differentiated signals are also compared.
Claim 7
Dependent Claim
26 words
A method according to claim 1 including an additional step of supplying said compared results on demand by telemetry from internally to externally of the body.
Claim 8
Dependent Claim
21 words
A method according to claim 6 including the step of altering a patient to an unfavorable assessment of the comparison results.
Claim 9
Dependent Claim
27 words
A method according to claim 7 wherein the unfavorable assessment of the comparison results is indicated in an audible manner to the patient having said transplanted heart.
Claim 10
Dependent Claim
30 words
A method according to claim 1 wherein only analog electrocardiac signals with a frequency signal range of 0.016 Hz to 1 KHz are supplied for conversion to the digital signals.
Claim 11
Dependent Claim
19 words
A method according to claim 1 wherein said analog to digital conversion occurs at a frequency of 1024 Hz.
Claim 12
Dependent Claim
19 words
A method according to claim 1 wherein the newly monitored differentiated signals and corresponding comparison results are periodically created.
Claim 13
Independent Claim
163 words
A method of monitoring a body reaction against a heart transplanted therein, comprising steps of: detecting inside the body analog electrocardiac signals from a newly transplanted heart in the body; within the body converting the analog signals to digital signals; within the body carrying out a first differentiation of the digital signals over a continuous time period to create reference differentiated signals; at a later time during monitoring of the heart, again detecting within the body analog electrocardiac signals from the transplanted heart; within the body converting the analog signals to digital signals; within the body carrying out a first differentiation of the digital signals over a continuous time period to create newly monitored differentiated signals; within the body comparing at least with respect to amplitude the newly monitored differentiated signals with the reference differentiated signals to create comparison results; recording and storing within the body the comparison results; and using the stored comparison results for analyzing body rejection of the transplanted heart.
Claim 14
Independent Claim
163 words
A method of monitoring a body reaction against a heart transplanted therein, comprising steps of: detecting inside the body analog electrocardiac signals from a newly transplanted heart in the body; within the body converting the analog signals to digital signals; within the body carrying out a first differentiation of the digital signals over a continuous time period to create reference differentiated signals; at a later time during monitoring of the heart, again detecting within the body analog electrocardiac signals from the transplanted heart; within the body converting the analog signals to digital signals; within the body carrying out a first differentiation of the digital signals over a continuous time period to create newly monitored differentiated signals; within the body comparing at least with respect to amplitude the newly monitored differentiated signals with the reference differentiated signals to create comparison results; recording and storing within the body the comparison results; and using the stored comparison results for analyzing body rejection of the transplanted heart.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1993-03-05 | 1993-09-04 | 1994-03-06 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1997-03-05 | 1997-09-04 | 1998-03-06 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2001-03-05 | 2001-09-04 | 2002-03-06 | $7700.00 | Window Closed / Lapsed |