Patent US4904480A successfully refreshed from Google Patents.
US4904480A
Expired / Lapsed
US
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Radiation compatible iodine formulation
Assignee: Becton Dickinson and Co
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Filing: 1988-09-19
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Granted: 1990-02-27
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Expires: 2008-09-19
Abstract
Abstract A germicidal iodine containing composition includes iodine, an iodophor, cupric ions and nitrite ions in an aqueous base. Iodide ions which form in the composition during radiation sterilization or prolonged shelf life are oxidized back to iodine by the cupric ions in a pH dependent reaction which consumes hydrogen ions formed concurrently with the iodide ions. Cuprous ions formed during the oxidation are spontaneously cycled back to cupric ions by traces of air present in the composition. The composition may include nitrite ions to augment the conversion of cuprous ions back to the cupric form.
Inventors
- 👤 Mohammed A. Khan
- 👤 John F. Moellmer
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 21:50
CPC Classifications
A; A01; A01N; A01N59/00; A01N59/12; A61; A61P; A61P17/00
Claims Analysis
Total Claims: 16
Claim 1
Independent Claim
88 words
A germicidal iodophor composition comprising an aqueous solution of about 1 to 20% by weight of povidone iodine having about 9-12% by weight iodine therein, about 0.001 to 0.1% by weight of a soluble cupric salt and about 0.001 to 0.1% by weight of a water soluble oxidizing agent, said cupric salt being capable of oxidizing iodide ions in said composition to iodine, said oxidizing agent being capable of oxidizing cuprous ions to cupric ions, whereby the pH and the iodine concentration in said composition remain substantially unchanged.
Claim 2
Dependent Claim
88 words
A germicidal iodophor composition comprising an aqueous solution of about 1 to 20% by weight of povidone iodine having about 9-12% by weight iodine therein, about 0.001 to 0.1% by weight of a soluble cupric salt and about 0.001 to 0.1% by weight of a water soluble oxidizing agent, said cupric salt being capable of oxidizing iodide ions in said composition to iodine, said oxidizing agent being capable of oxidizing cuprous ions to cupric ions, whereby the pH and the iodine concentration in said composition remain substantially unchanged.
Claim 3
Dependent Claim
13 words
The composition of claim 1 wherein said povidone iodine is USP povidone iodine.
Claim 4
Dependent Claim
11 words
The composition of claim 1 wherein said salt is cupric sulfate.
Claim 5
Dependent Claim
24 words
The composition of claim 1 wherein said oxidizing agent is selected from the group consisting of an alkali metal nitrite, sulfite, nitrate and chlorate.
Claim 6
Dependent Claim
30 words
The composition of claim 1 further comprising an ingredient selected from the group consisting of a surfactant, thickening agent, an emollient, a foam stabilizer, a fragrance compound and a dye.
Claim 7
Dependent Claim
12 words
The composition of claim 5 wherein said surfactant is a nonionic surfactant.
Claim 8
Dependent Claim
29 words
The composition of claim 6 wherein said nonionic surfactant is selected from the group consisting of an alkylphenoxypoly(ethyleneoxy) alcohol, a polyalkyleneoxyglycol, an amine oxide and an ethoxylated primary alcohol.
Claim 9
Dependent Claim
103 words
A germicidal iodophor composition comprising: an aqueous solution of about 6 to 12% by weight of povidone iodine, about 1 to 10% by weight of a nonionic surfactant, a buffer adapted to maintain the pH of said solution from 5 to 6.5, about 0.01 to 0.1% by weight of a soluble cupric salt and about 0.01 to 0.1% by weight of a nitrite salt, said cupric salt being capable of oxidizing iodide ions in said composition to iodine, said nitrite salt being capable of oxidizing cuprous ions to cupric ions, whereby the pH and the iodine concentration in said composition remain substantially unchanged.
Claim 10
Dependent Claim
103 words
A germicidal iodophor composition comprising: an aqueous solution of about 6 to 12% by weight of povidone iodine, about 1 to 10% by weight of a nonionic surfactant, a buffer adapted to maintain the pH of said solution from 5 to 6.5, about 0.01 to 0.1% by weight of a soluble cupric salt and about 0.01 to 0.1% by weight of a nitrite salt, said cupric salt being capable of oxidizing iodide ions in said composition to iodine, said nitrite salt being capable of oxidizing cuprous ions to cupric ions, whereby the pH and the iodine concentration in said composition remain substantially unchanged.
Claim 11
Dependent Claim
11 words
The composition of claim 8 wherein said salt is cupric sulfate.
Claim 12
Dependent Claim
14 words
The composition of claim 8 wherein said nitrite salt is an alkali metal nitrite.
Claim 13
Dependent Claim
26 words
A surgical scrub package comprising a sponge and brush, said sponge and brush having incorporated therein a germicidally effective quantity of the composition of claim 8.
Claim 14
Dependent Claim
11 words
The package of claim 11 wherein said sponge is of foam.
Claim 15
Dependent Claim
11 words
The package of claim 11 wherein said brush is of polyethylene.
Claim 16
Dependent Claim
15 words
The package of claim 11 wherein said sponge and brush are combined in an assembly.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1993-02-26 | 1993-08-28 | 1994-02-27 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1997-02-26 | 1997-08-28 | 1998-02-27 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2001-02-26 | 2001-08-28 | 2002-02-27 | $7700.00 | Window Closed / Lapsed |