Patent US4900554A successfully refreshed from Google Patents.
US4900554A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Adhesive device for application to body tissue
Assignee: Teikoku Seiyaku Co Ltd
•
Filing: 1987-12-23
•
Granted: 1990-02-13
•
Expires: 2007-12-23
Abstract
Abstract An adhesive device for application to body tissue having an adhesive layer and a backing layer positioned over one side of the adhesive layer. The adhesive layer includes one or more acrylic acid polymers having adhesive properties upon dissolution or swelling in water, and at least one water insoluble cellulose derivative. The backing layer is water insoluble or sparingly water soluble.
Inventors
- 👤 Norio Yanagibashi
- 👤 Setsuo Iwasaki
- 👤 Takafumi Mizobuchi
- 👤 Ryoji Konishi
- 👤 Tatsuya Konishi
- 👤 Takahiko Wato
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-27 13:58
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/0012; A61K9/0053; A61K9/006; A61L; A61L15/00; A61L15/16; A61L15/42; A61L15/58; A61L15/585; A61F; A61F13/00; A61F2013/00361; A61F2013/00655; A61F2013/0071
Claims Analysis
Total Claims: 14
Claim 1
Independent Claim
128 words
An oral cavity adhesive device for application to a mucous membrane or oral cavity tissue of an individual, comprising: an adhesive layer including a mixture of at least one acrylic acid polymer, a water-insoluble cellulose derivative, and a pharmaceutical preparation, said adhesive layer having an adhesive surface adherable to a mucous membrane or oral cavity tissue; and a water-insoluble or sparingly water-soluble backing layer secured over said adhesive layer on a side opposite the adhesive surface; wherein said acrylic acid polymer exhibits adhesiveness upon dissolution or swelling when applied to the mucous membrane or oral cavity tissue, and wherein the weight ratio of acrylic acid polymer to water-insoluble cellulose derivative is within a range which provides sustained adhesiveness of the adhesive layer with substantially no foreign body sensation.
Claim 2
Dependent Claim
128 words
An oral cavity adhesive device for application to a mucous membrane or oral cavity tissue of an individual, comprising: an adhesive layer including a mixture of at least one acrylic acid polymer, a water-insoluble cellulose derivative, and a pharmaceutical preparation, said adhesive layer having an adhesive surface adherable to a mucous membrane or oral cavity tissue; and a water-insoluble or sparingly water-soluble backing layer secured over said adhesive layer on a side opposite the adhesive surface; wherein said acrylic acid polymer exhibits adhesiveness upon dissolution or swelling when applied to the mucous membrane or oral cavity tissue, and wherein the weight ratio of acrylic acid polymer to water-insoluble cellulose derivative is within a range which provides sustained adhesiveness of the adhesive layer with substantially no foreign body sensation.
Claim 3
Dependent Claim
31 words
An adhesive device as claimed in claim 1, wherein the water-insoluble cellulose derivative is ethyl cellulose, carboxymethyl cellulose, calcium carboxymethyl cellulose, carboxymethylethyl cellulose, cellulose acetate, cellulose acetatephthalate or hydroxypropylmethyl cellulose phthalate.
Claim 4
Dependent Claim
27 words
An adhesive device as claimed in claim 1, wherein the weight ratio of acrylic acid polymer to water-insoluble cellulose derivative is from about 99:1 to about 50:50.
Claim 5
Dependent Claim
27 words
An adhesive device as claimed in claim 1, wherein the weight ratio of acrylic acid polymer to water-insoluble cellulose derivative is from about 98:2 to about 70:30.
Claim 6
Dependent Claim
33 words
An adhesive device as claimed in claim 1, wherein the backing layer is ethylcellulose, cellulose acetate, cellulose acetatephthalate, hydroxypropylmethyl cellulose phthalate, vinyl acetate resin or a pharmacologically acceptable water-soluble polymer insolubilized by cross-linking.
Claim 7
Independent Claim
151 words
A method for providing the sustained release of a pharmaceutical preparation to an individual, comprising the steps of: (a) applying to a mucous membrane or oral cavity tissue of the individual an adhesive device comprising: (1) an adhesive layer including a mixture of at least one acrylic acid polymer which exhibit adhesiveness upon dissolution or swelling when applied to said mucous membrane or oral cavity tissue and a water-insoluble cellulose derivative, and further including a pharmaceutical preparation; and (2) a water-insoluble or sparingly water-soluble backing layer secured over said adhesive layer on a side opposite the adhesive surface; and (b) contacting said adhesive device with a bodily fluid, thereby releasing said pharmaceutical preparation from said adhesive layer in a controlled manner; wherein the weight ratio of acrylic acid polymer to water-insoluble cellulose derivative is within a range which provides sustained adhesiveness of the adhesive layer with substantially no foreign body sensation.
Claim 8
Independent Claim
151 words
A method for providing the sustained release of a pharmaceutical preparation to an individual, comprising the steps of: (a) applying to a mucous membrane or oral cavity tissue of the individual an adhesive device comprising: (1) an adhesive layer including a mixture of at least one acrylic acid polymer which exhibit adhesiveness upon dissolution or swelling when applied to said mucous membrane or oral cavity tissue and a water-insoluble cellulose derivative, and further including a pharmaceutical preparation; and (2) a water-insoluble or sparingly water-soluble backing layer secured over said adhesive layer on a side opposite the adhesive surface; and (b) contacting said adhesive device with a bodily fluid, thereby releasing said pharmaceutical preparation from said adhesive layer in a controlled manner; wherein the weight ratio of acrylic acid polymer to water-insoluble cellulose derivative is within a range which provides sustained adhesiveness of the adhesive layer with substantially no foreign body sensation.
Claim 9
Dependent Claim
17 words
A method as claimed in claim 6, wherein the adhesive device is applied to oral cavity tissue.
Claim 10
Dependent Claim
20 words
A method as claimed in claim 6, wherein the oral cavity tissue comprises gingival tissue, lip tissue or a tooth.
Claim 11
Dependent Claim
62 words
An adhesive device as claimed in claim 1, wherein said pharmaceutical preparation comprises an analgesic inflammatory agent, a steroidal anti-inflammatory agent, an antihistimine, a local anesthetic, a bactericide, a disinfectant, a vasoconstriction, a hemostatic, a chemotherapeutic drug or an antibiotic, said pharmaceutical preparation being present in said adhesive layer in an amount of from about 0.001 to about 20 percent by weight.
Claim 12
Dependent Claim
15 words
An adhesive device as claimed in claim 1, wherein said pharmaceutical preparation comprises methylparaoxybenzoic acid.
Claim 13
Dependent Claim
15 words
An adhesive device as claimed in claim 1, wherein said pharmaceutical preparation comprises dibucaine hydrochloride.
Claim 14
Dependent Claim
15 words
An adhesive device as claimed in claim 1, wherein said pharmaceutical preparation comprises tranexamic acid.
References Cited (Backward Citations)
US4668232A
Cited
US4738848A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1993-02-12 | 1993-08-14 | 1994-02-13 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1997-02-12 | 1997-08-14 | 1998-02-13 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2001-02-12 | 2001-08-14 | 2002-02-13 | $7700.00 | Window Closed / Lapsed |