Patent US4900552A successfully refreshed from Google Patents.
US4900552A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Mucoadhesive buccal dosage forms
Assignee: Actavis Laboratories UT Inc
•
Filing: 1988-03-30
•
Granted: 1990-02-13
•
Expires: 2008-03-30
Abstract
Abstract A trilaminate film suitable for prolonged and sustained delivery of an active ingredient in a buccal cavity is disclosed. A hydratable mucoadhesive base layer, a non-adhesive reservoir layer and a water-impermeable carrier film sandwiched between and bonded to the base layer and the reservoir layer are the elements which form the trilaminate film.
Inventors
- 👤 Dilip R. Sanvordeker
- 👤 Sau-Hung S. Leung
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 03:00
CPC Classifications
A; A61; A61Q; A61Q11/00; A61K; A61K8/00; A61K8/02; A61K8/0208; A61K9/00; A61K9/0012; A61K9/0053; A61K9/006
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
75 words
A buccal dosage form suitable for delivery of an active ingredient in a buccal cavity and comprising: a hydratable mucoadhesive base layer; a non-adhesive reservoir layer; and a water-impermeable barrier sandwiched between and bonded to said base layer and said reservoir layer; said reservoir layer comprising a plasticized filmforming cellulose ester, a dehydrated hydrogel and said active ingredient to be dispersed directly into the buccal cavity; and said water-impermeable barrier comprising a cellulose ester film.
Claim 2
Dependent Claim
75 words
A buccal dosage form suitable for delivery of an active ingredient in a buccal cavity and comprising: a hydratable mucoadhesive base layer; a non-adhesive reservoir layer; and a water-impermeable barrier sandwiched between and bonded to said base layer and said reservoir layer; said reservoir layer comprising a plasticized filmforming cellulose ester, a dehydrated hydrogel and said active ingredient to be dispersed directly into the buccal cavity; and said water-impermeable barrier comprising a cellulose ester film.
Claim 3
Dependent Claim
45 words
The buccal dosage form in accordance with claim 1 wherein the mucoadhesive base layer is constituted by a member of the group consisting of water-swellable, but water-insoluble, fibrous, cross-linked carboxy-functional polymers, hydrophilic polysaccharide gums, cross-linked alignate gum gels, water-dispersible polycarboxylated vinyl polymers, and mixtures thereof.
Claim 4
Dependent Claim
30 words
The buccal dosage form in accordance with claim 2 wherein the hydrophilic polysaccharide gum is a member of the group consisting of a natural plant exudate and a seed gum.
Claim 5
Dependent Claim
37 words
The buccal dosage form in accordance with claim 2 wherein the hydrophilic polysaccharide gum is a member of the group consisting of karaya gum, ghatti gum, locust bean gum, guar gum, psillium seed gum and mixtures thereof.
Claim 6
Dependent Claim
32 words
The buccal dosage form in accordance with claim 1 wherein the cellulose ester film is a member of the group comprising of cellulose acetate butyrate, cellulose acetate isobutyrate, and cellulose acetate propionate.
Claim 7
Dependent Claim
34 words
The buccal dosage form in accordance with claim 1 wherein the weight ratio of cellulose ester to dehydrated hydrogel in the reservoir layer is in the range of about 7:3 to about 1:4, respectively.
Claim 8
Dependent Claim
34 words
The buccal dosage form in accordance with claim 1 wherein the weight ratio of cellulose ester to dehydrated hydrogel in the reservoir layer is in the range of about 6:4 to about 1:3, respectively.
Claim 9
Dependent Claim
23 words
The buccal dosage form in accordance with claim 1 wherein the hydrogel is a combination of a polyoxyalkylene block copolymer and alginic acid.
Claim 10
Dependent Claim
27 words
The buccal dosage form in accordance with claim 8 wherein the weight ratio of polyoxyalkylene block copolymer to alginic acid is about 5 to about 0.2, respectively.
Claim 11
Dependent Claim
28 words
The buccal dosage form in accordance with claim 8 wherein the polyoxyalkylene block copolymer contains oxyethylene chains and oxypropylene chains in a weight ratio of about 7:3, respectively.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1993-02-12 | 1993-08-14 | 1994-02-13 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1997-02-12 | 1997-08-14 | 1998-02-13 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2001-02-12 | 2001-08-14 | 2002-02-13 | $7700.00 | Window Closed / Lapsed |