US4900539A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Radiohalogenated thienylethylamine derivatives for evaluating local cerebral blood flow
Assignee: United States Department of Energy
•
Filing: 1988-12-22
•
Granted: 1990-02-13
•
Expires: 2008-12-22
Abstract
Abstract Radiopharmaceuticals useful in brain imaging comprising radiohalogenated thienylethylamine derivatives. The compounds are 5-halo-thiophene-2-isopropyl amines able to cross the blood-brain barrier and be retained for a sufficient length of time to allow the evaluation or regional blood flow by radioimaging of the brain.
Inventors
- 👤 Mark M. Goodman
- 👤 Furn F. Knapp, Jr.
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 22:29
CPC Classifications
A; A61; A61K; A61K51/00; A61K51/02; A61K51/04; A61K51/041; A61K51/0429; A61K51/0431; A61K2123/00
Claims Analysis
Total Claims: 14
Claim 1
Independent Claim
25 words
A composition of matter comprising a radiohalogenated thienylmonoamine having the structure ##STR2## wherein *X is a radiohalogen and R is H or alkyl or aryl.
Claim 2
Dependent Claim
25 words
A composition of matter comprising a radiohalogenated thienylmonoamine having the structure ##STR2## wherein *X is a radiohalogen and R is H or alkyl or aryl.
Claim 3
Dependent Claim
9 words
The composition of matter of claim 1 comprising ##STR3##
Claim 4
Dependent Claim
21 words
The composition of matter of claim 1 wherein said radiohalogen is selected from the group I-122, I-123, I-125, Br-75 and Br-82.
Claim 5
Dependent Claim
21 words
The composition of matter of claim 2 wherein said radiohalogen is selected from the group I-122, I-123, I-125, Br-75 and Br-82.
Claim 6
Dependent Claim
27 words
The composition of matter of claim 3 wherein said radiohalogen is selected from the group I-125 and Br-82 and said R is selected from the group H.
Claim 7
Dependent Claim
18 words
The composition of matter of claim 4 wherein said radiohalogen is selected from the group I-125 and Br-82.
Claim 8
Dependent Claim
55 words
A process for radioimaging comprising: mixing with a suitable administering medium a radiohalogenated thienylmonoamine having the structure ##STR4## wherein *X is a radiohalogen and R is H or alkyl or aryl; injecting an effective amount of said mixture into a warm blooded animal; allowing said mixture to cross the blood-brain barrier; and recording a radioimage.
Claim 9
Dependent Claim
55 words
A process for radioimaging comprising: mixing with a suitable administering medium a radiohalogenated thienylmonoamine having the structure ##STR4## wherein *X is a radiohalogen and R is H or alkyl or aryl; injecting an effective amount of said mixture into a warm blooded animal; allowing said mixture to cross the blood-brain barrier; and recording a radioimage.
Claim 10
Dependent Claim
11 words
The process of claim 7 wherein said radiohalogenated thienylmonoamine comprises ##STR5##
Claim 11
Dependent Claim
19 words
The process of claim 7 wherein said radiohalogen is selected from the group I-122, I-123, I-125, Br-75 and Br-82.
Claim 12
Dependent Claim
19 words
The process of claim 8 wherein said radiohalogen is selected from the group I-122, I-123, I-125, Br-75 and Br-82.
Claim 13
Dependent Claim
25 words
The process of claim 9 wherein said radiohalogen is selected from the group I-125 and Br-82 and said R is selected from the group H.
Claim 14
Dependent Claim
16 words
The process of claim 10 wherein said radiohalogen is selected from the group I-125 and Br-82.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1993-02-12 | 1993-08-14 | 1994-02-13 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1997-02-12 | 1997-08-14 | 1998-02-13 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2001-02-12 | 2001-08-14 | 2002-02-13 | $7700.00 | Window Closed / Lapsed |