US4894451A
Expired / Lapsed
US
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Unsymmetrical 1,4-bis(aminoalkylamino)-anthracene-9, 10-diones and derivatives
Assignee: University of Vermont
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Filing: 1988-07-19
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Granted: 1990-01-16
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Expires: 2008-07-19
Abstract
Abstract The disclosure describes unsymmetrical 1,4-bis-(aminoalkylamino)-anthracene-9,10-diones useful in the treatment of neoplasms. Also described is a process of preparing same starting from 1,4-dimethoxyanthracene-9,10-dione which is reacted with an aminoalkylamine. The reaction product is treated with a dialkylaminoethylamine or a N-heteroethylamine to give the unsymmetrical compound.
Inventors
- 👤 A. Paul Krapcho
- 👤 Miles P. Hacker
- 👤 John J. Landi, Jr.
- 👤 J. J. McCormack
- 👤 Kenneth J. Shaw
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 18:19
CPC Classifications
C; C07; C07C; C07C225/00; C07C225/24; C07C225/26; C07C225/32; C07C225/34; C07C233/00; C07C233/01; C07C233/34; C07C233/35; C07C233/36; C07C2603/00; C07C2603/02; C07C2603/04; C07C2603/22; C07C2603/24
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
50 words
A compound having the formula ##STR5## wherein: B represents a radical selected from a dialkyl amino group having 1 to 4 carbons and a N-heterocyclic radical having 4, 5 or 6 carbon atoms, n represents 3, 4 or 5, and R represents alkanoyl or a non-toxic physiologically acceptable salt thereof.
Claim 2
Dependent Claim
50 words
A compound having the formula ##STR5## wherein: B represents a radical selected from a dialkyl amino group having 1 to 4 carbons and a N-heterocyclic radical having 4, 5 or 6 carbon atoms, n represents 3, 4 or 5, and R represents alkanoyl or a non-toxic physiologically acceptable salt thereof.
Claim 3
Dependent Claim
18 words
A compound according to claim 1, wherein B represents a dialkyl amino group selected from dimethylamino and diethylamino.
Claim 4
Dependent Claim
21 words
A compound according to claim 1, wherein B represents a radical selected from the group consisting of morpholino, pyrrolidino and piperidino.
Claim 5
Dependent Claim
19 words
A compound according to claim 1, wherein R is selected from the group consisting of acetyl, propionyl and methanesulfonyl.
Claim 6
Dependent Claim
10 words
A compound according to claim 1, wherein R is acetyl.
Claim 7
Dependent Claim
10 words
A compound according to claim 1, wherein n is 3.
Claim 8
Dependent Claim
10 words
A compound according to claim 1, wherein n is 4.
Claim 9
Dependent Claim
10 words
A compound according to claim 1, wherein n is 5.
Claim 10
Dependent Claim
22 words
A compound according to claim 1, where R represents COCH 3 , n represents 3, B represents (CH 3 ) 2 N.
Claim 11
Dependent Claim
23 words
A compound according to claim 1, where R represents COCH 3 , n represents 4, and B represents (CH 3 ) 2 N.
Claim 12
Dependent Claim
23 words
A compound according to claim 1, where R represents COCH 3 , n represents 5, and B represents (CH 3 ) 2 N.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1993-01-15 | 1993-07-17 | 1994-01-16 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1997-01-15 | 1997-07-17 | 1998-01-16 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2001-01-15 | 2001-07-17 | 2002-01-16 | $7700.00 | Window Closed / Lapsed |