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US4893627A
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Method for nuclear magnetic resonance imaging using deuterum as a contrast agent
Assignee: United States Department of Energy
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Filing: 1988-05-26
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Granted: 1990-01-16
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Expires: 2008-05-26
Abstract
Abstract A method for in vivo NMR imaging of the blood vessels and organs of a patient characterized by using a dark dye-like imaging substance consisting essentially of a stable, high-purity concentration of D 2 O in a solution with water.
Inventors
- 👤 Joseph J. Kehayias
- 👤 Darrel D. Joel
- 👤 William H. Adams
- 👤 Harry L. Stein
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 01:24
CPC Classifications
A; A61; A61K; A61K49/00; A61K49/06; A61K49/18; Y; Y10; Y10T; Y10T436/00; Y10T436/24
Claims Analysis
Total Claims: 4
Claim 1
Independent Claim
112 words
A method for in vivo NMR imaging consisting of positioning a patient within the magnetic field of an energized NMR system, administering an acceptable NMR imaging amount of stable, high-purity D 2 O in isosmotic water solution by injecting the solution through a catheter into a blood vessel of the patient, said acceptable amount of D 2 O being sufficient to enable the administered D 2 O to form dark dye-like images as the solution is subjected to the H-1 resonance of the system, said H-1 resonance being effected at a frequency at which D 2 O will not resonate, detecting H-1 resonance signals, and processing said signals to provide an image.
Claim 2
Independent Claim
112 words
A method for in vivo NMR imaging consisting of positioning a patient within the magnetic field of an energized NMR system, administering an acceptable NMR imaging amount of stable, high-purity D 2 O in isosmotic water solution by injecting the solution through a catheter into a blood vessel of the patient, said acceptable amount of D 2 O being sufficient to enable the administered D 2 O to form dark dye-like images as the solution is subjected to the H-1 resonance of the system, said H-1 resonance being effected at a frequency at which D 2 O will not resonate, detecting H-1 resonance signals, and processing said signals to provide an image.
Claim 3
Dependent Claim
66 words
An NMR imaging method comprising using a dense solution of D 2 O and H 2 O as an imaging dye said dense solution of D 2 O and H 2 O having a ratio of D 2 O/H 2 O equal to at least 99.00% by weight D 2 O, causing H-1 resonance, detecting H-1 resonance signals, and processing said signals to provide an image.
Claim 4
Dependent Claim
66 words
An NMR imaging method comprising using a dense solution of D 2 O and H 2 O as an imaging dye said dense solution of D 2 O and H 2 O having a ratio of D 2 O/H 2 O equal to at least 99.00% by weight D 2 O, causing H-1 resonance, detecting H-1 resonance signals, and processing said signals to provide an image.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1993-01-15 | 1993-07-17 | 1994-01-16 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1997-01-15 | 1997-07-17 | 1998-01-16 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2001-01-15 | 2001-07-17 | 2002-01-16 | $7700.00 | Window Closed / Lapsed |