Abstract An orally administrable pharmaceutical preparation of improved flavoring characteristics composed of a core material containing a drug and a coated layer applied to its surface, said coated layer being composed of a particulate polymeric substance having an average particle diameter of not more than 60 microns and being soluble in gastric juice; and a process for producing said orally administrable pharmaceutical preparation, which comprises causing minute liquid droplets of a volatile liquid containing a drug and optionally a gastric juice-soluble polymeric substance to fall onto a powder bed composed of a gastric juice-soluble particulate polymeric substance having an average particle diameter of not more than 60 microns to coat the surface of the liquid droplets with the gastric juice-soluble particulate polymeric substance, and drying the coated particles.
An orally administrable pharmaceutical preparation of improved flavoring characteristics composed of a core material containing a drug and a coating layer applied to its surface, said coating layer being composed of a particulate polymeric substance having an average particle diameter of not more than 60 microns and being soluble in gastric juice.
Claim 2
Dependent Claim
52 words
An orally administrable pharmaceutical preparation of improved flavoring characteristics composed of a core material containing a drug and a coating layer applied to its surface, said coating layer being composed of a particulate polymeric substance having an average particle diameter of not more than 60 microns and being soluble in gastric juice.
Claim 3
Dependent Claim
21 words
The pharmaceutical preparation of claim 1 wherein said gastric juice-soluble polymeric substance is polyvinyl acetal diethylaminoacetate or dimethylaminoethyl methacrylate/methacrylic acid copolymer.
Claim 4
Dependent Claim
22 words
The pharmaceutical preparation of claim 1 wherein said gastric juice-soluble polymeric substance has an average particle diameter of 5 to 20 microns.
Claim 5
Dependent Claim
30 words
The pharmaceutical preparation of claim 1 which has an average particle diameter of at least 10 times as large as the average particle diameter of said gastric juice-soluble polymeric substance.
Claim 6
Dependent Claim
18 words
The pharmaceutical preparation of claim 4 which has an average particle diameter of not more than 600 microns.
Claim 7
Dependent Claim
12 words
A unit dosage form prepared from the pharmaceutical preparation of claim 1.
Claim 8
Dependent Claim
18 words
The unit dosage form of claim 6 which is a granule, pellet, capsule, pill, tablet, sugar-coated tablet or.
Claim 9
Dependent Claim
77 words
A process for producing the orally administrable pharmaceutical preparation of claim 1, which comprises causing minute liquid droplets of a volatile liquid containing a drug and optionally a gastric juice-soluble polymeric substance to fall onto a powder bed composed of a gastric juice-soluble particulate polymeric substance having an average particle diameter of not more than 60 microns to coat the surface of the liquid droplets with the gastric juice-soluble particulate polymeric substance, and drying the coated particles.